Interleukin-13 sensitivity and receptor phenotypes of human glial cell lines: Non-neoplastic glia and low-grade astrocytoma differ from malignant glioma

Cancer Immunology Immunotherapy

Volumn 49, Issue 6, 2000, Pages 319-324

  Liu, Haiyan ^a   Jacobs, Barbara S ^a   Liu, Jinbo ^a   Prayson, Richard A ^b   Estes, Melinda L ^a   Barnett, Gene H ^b   Barna, Barbara P ^a  

^a METROHEALTH MEDICAL CENTER   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Astrocytes; Astrocytoma; Interleukin 13; Receptors; STAT6

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4 RECEPTOR; STAT6 PROTEIN;

ADULT; ARTICLE; ASTROCYTOMA; CELL LINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA SYNTHESIS; GLIA CELL; GLIOMA; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0033868052     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620000110     Document Type: Article

References (26)

1. cDNA cloning and characterization of the human Interleukin 13 receptor alpha chain
2. Human astrocyte growth regulation: Interleukin-4 sensitivity and receptor expression
3. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor α chain
4. Human glioma cells overexpress receptors for Interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin
5. Receptor for interleukin (IL) 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells
6. Novel anti-brain tumor cytotoxins specific for cancer cells
7. Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas
8. Receptor for interleukin 13 is abundantly and specifically over-expressed in patients with glioblastoma multiforme
9. Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma
10. Interleukin 4 down-regulates adult human astrocyte DNA synthesis and proliferation
11. The interleukin-4-interleukin-13 receptor of human synovial fibroblasts: Overexpression of the nonsignaling interleukin-13 receptor α2
12. A novel 4-kb interleukin-13 receptor α mRNA expressed in human B, T, and endothelial cells encoding an alternative type II interleukin-4/interleukin-13 receptor
13. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor
14. Biological activity of IL-4 and IL-13 on human endothelial cells: Functional evidence that both cytokines act through the same receptor
15. The CDK inhibitor, p27 (kip1) is required for IL-4 regulation of astrocyte proliferation
16. Anti-sense oligonucleotide of p21 (waf1/cip1) prevents Interleukin 4-mediated elevation of p27 (kip1) in low grade astrocytoma cells
17. Cloning of the human IL-13Rαl chain and reconstitution with the IL-4Rα of a functional IL-4/IL-13 receptor complex
18. The IL-4 receptor: Signaling mechanisms and biologic functions
19. The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor
20. IL-4 and IL-13 activate the JAK2 tyrosine kinase and STAT6 in cultured human vascular endothelial cells through a common pathway that does not involve the γc chain
21. Interleukin-2 receptor γ chain: A functional component of the interleukin-4 receptor
22. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
23. Characterization and comparison of the interleukin-13 receptor with the interleukin-4 receptor on several cell types
24. The role of IL-13 and its receptor in allergy and inflammatory responses
25. The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor