Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat

Hepatology

Volumn 26, Issue 1, 1997, Pages 90-97

  Nanji, Amin A ^a,b   Rahemtulla, Amir ^a   Daly, Thomas ^a   Khwaja, Shamsuddin ^a   Miao, Lili ^a   Zhao, Shuping ^a   Tahan, Steven R ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN SYNTHASE; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL KILLING; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME INDUCTION; ICOSANOID METABOLISM; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER INJURY; LIVER NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

EID: 0030981186     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260112     Document Type: Article

References (58)

1. Nanji AA, French SW. Dietary factors and alcoholic cirrhosis. Alcohol Clin Exp Res 1986;10:271-273.
2. Nanji AA, Mendenhall CL, French SW. Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res 1989;13:15-19.
3. Nanji AA, French SW. Dietary linoleic acid is required for the development of experimental alcoholic liver disease. Life Sci 1989;44:223-227.
4. Nanji AA, Sadrzadeh SMH, Dannenberg AJ. Liver microsomal fatty acid composition in ethanol-fed rats: effect of different dietary fats and relationship to liver injury. Alcohol Clin Exp Res 1994;18:1024-1028.
5. Nanji AA, Sadrzadeh SMH, Thomas P, Yamanaka T. Eicosanoid profile and evidence for endotoxin tolerance in chronic ethanol-fed rats. Life Sci 1994;55:611-620.
6. 2. Am J Pathol 1993;142:367-373.
7. Habenicht AJR, Salbach P, Goerig M, Zeh W, Janssen-Timmen U, Blattner C, King WC, et al. The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet derived growth factor. Nature 1990;345:634-636.
8. Salbach PB, Specht E, Von-Hodenberg E, Kossman J, Janssen-Timmen U, Schneider WJ, Hugger P, et al. Differential low density lipoprotein receptor-dependent formation of eicosanoids in human blood-derived monocytes. Proc Natl Acad Sci U S A 1992;89:2439-2443.
9. Seitz HK, Kuhn B, Von-Hodenberg E, Fiehn W, Condradt C, Simanowski UA. Increased messenger RNA levels for low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat liver after long-term ethanol ingestion. HEPATOLOGY 1994;20:487-493.
10. Feng L, Sun W, Xia Y, Tang WW, Chanmugam P, Soyooka E, Wilson CB, Hwang D. Clong two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch Biochem Biophys 1993;307:361-368.
11. Otto JC, Smith WL. Prostaglandin endoperoxide synthases-1 and -2. J Lipid Mediat Cell Signal 1995;12:139-156.
12. Herschman HR. Prostaglandin synthase-2. Biochim Biophys Acta 1996; 1299:125-140.
13. Nanji AA, Miao L, Khwaja S, Zhao S, Fogt F, Tahan SR, Dannenberg AJ. Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. Gastroenterology 1997;112:943-951.
14. Dietschy JM, Turley SD, Spady DK. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 1993;34:1637-1659.
15. Kovanen PT, Brown MS, Basu SK, Bilheimer DW, Goldstein JL. Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits. Proc Natl Acad Sci U S A 1981;78:1396-1400.
16. Roach PD, Balasubramanian S, Hirata F, Abbey M, Szanto A, Simons LA, Nesterl PJ. The low-density lipoprotein receptor and cholesterol synthesis are affected differently by dietary cholesterol in the rat. Biochim Biophys Acta 1993;1170:165-172.
17. Nanji AA, Zhao S, Sadrzadeh SMH, Dannenberg AJ, Tahan SR, Waxman DJ. Markedly enhanced cytochrome P4502E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol fed rats. Alcohol Clin Exp Res 1994;18:1280-1285.
18. Tsukamoto H, Gaal K, French SW. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. HEPATOLOGY 1990; 12:599-608.
19. French SW, Miyamoto K, Tsukamoto H. Ethanol-induced fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin Exp Res 1986; 10:13S-19S.
20. Nanji AA, Khwaja S, Tahan SR, Sadrzadeh SMH. Plasma levels of a novel noncyclooxygenase-derived prostanoid (8-isoprostane) correlate with severity of liver injury in experimental alcoholic liver disease. J Pharmacol Exp Ther 1994;269:1280-1285.
21. Allain CC, Poon LS, Chang CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974;20:479-475.
22. Bucolo G, David H. Quantitative determination of serum triglycerides by use of enzymes. Clin Chem 1973;19:476-481.
23. Warnick GR, Cheung MC, Albers JJ. Comparison of current methods for high-density lipoproprotein cholesterol quantitation. Clin Chem 1979;25:596-604.
24. McNamara JR, Cohn JS, Wilson PWF, Schaefer EJ. Calculated values for low-density lipoprotein cholesterol in the assessment of lipid abnormalities and coronary disease risk. Clin Chem 1990;36:36-42.
25. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
26. Recknagel RO, Glende EA. Spectrophotometric method of lipid conjugated dienes. Methods Enzymol 1984;105:331-337.
27. Fitzgerald GA, Pedersen AK, Patrono C. Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation 1983; 67:1174-1177.
28. 2 in the human circulation. Anal Biochem 1986;155:198-205.
29. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
30. Nanji AA, Griniuviene B, Yacoub LK, Fogt F, Tahan SR. Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to endotoxemia and TNFα messenger RNA. Exp Mol Pathol 1995;62:42-51.
31. Nanji AA, Zhao S, Sadrzadeh SMH, Waxman DJ. Use of reverse transcription-polymerase chain reaction to evaluate in-vivo cytokine gene expression in rats fed ethanol for long periods. HEPATOLOGY 1994;19: 1483-1487.
32. Nanji AA, Tahan SR, Golding M, Khwaja S, Rahemtulla A, Lalani EN. Role for transforming growth factor-Beta 1 in inhibiting endothelial cell proliferation in experimental alcoholic liver disease. Am J Pathol 1996; 148:739-747.
33. Matsuoka M, Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell derived transforming growth factor-β: implication for a pathogenic role in alcoholic liver fibrogenesis. HEPATOLOGY 1990;11:599-605.
34. Lefevre AF, DeCarli LM, Lieber CS. Effect of ethanol on cholesterol and bile acid metabolism. J Lipid Res 1972;13:48-55.
35. Lakshmanan MR, Veech RL. Short and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7 α-hydroxylase activities. J Lipid Res 1977;18:325-330.
36. Field FJ, Boydstun JS, LaBrecque DR. Effects of chronic ethanol ingestion on hepatic and intestinal acyl coenzyme A: cholesterol acyltransferase and 3-hydroxy-3-methylglutaryl coenzyme A reductase in the rat. HEPATOLOGY 1985;5:133-138.
37. Venkatesan S, Simpson KJ, Peters TJ. Hepatic cholesterol synthesis and esterification in rats after chronic ethanol feeding. Clin Sci 1988;74: 407-412.
38. VanLenten BJ, Fogelman AM, Haberland ME, Edwards PA. The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide. Proc Natl Acad Sci U S A 1986;83:2704-2708.
39. Netea MC, Demacker PNM, Kullberg BJ, Boerman OC, Verschueren I, Stalenhoef AFH, Van der Meer JWM. Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections. J Clin Invest 1996;97:1366-1372.
40. Ohlsson BG, Englund MCO, Karlsson AK, Knutsen E, Erixon C, Skribeck H, Liu Y, et al. Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-KB to DNA and subsequent expression of tumor necrosis factor-α and interleukin-1β in macrophages. J Clin Invest 1996;98:78-89.
41. Croft KD, Puddey IB, Rakic V, Abu-Amsha R, Dimmit SB, Beilin LJ. Oxidative susceptibility of low-density lipoproteins-influence of regular alcohol use. Alcohol Clin Exp Res 1996;20:980-984.
42. Chaudri G, Clark IA. Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide induced release of tumor necrosis factor. J Immunol 1989;143:1290-1296.
43. Pobregmak H, Mathews W, Mitchell J, Russo A, Samuni A, Pass H. Spin trap protection from tumor necrosis factor cytotoxicity. J Surg Res 1991; 50:469-475.
44. Parasassi T, Giusti AM, Raimond M, Ravagnan G, Sapora O, Gratton E. Cholesterol protects the phospholipid bilayer from oxidative damage. Free Rad Biol Med 1995;19:511-516.
45. Smith LL. Another cholesterol hypothesis: cholesterol as an antioxidant. Free Rad Biol Med 1991;11:47-61.
46. Feng L, Xia Y, Garcia GE, Hwang D, Wilson CB. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin 1, tumor necrosis factor-α and lipopolysaccharide. J Clin Invest 1995;95:1669-1675.
47. Herschman HR. Prostaglandin synthase 2. Biochim Biophys Acta 1996; 1299:125-140.
48. Pomerantz KB, Summers B, Hajjar DP. Eicosanoid metabolism in cholesterol-enriched arterial smooth muscle cells. Evidence for reduced post-transcriptional processing of cyclooxygenase I and reduced cyclooxygenase II gene expression. Biochemistry 1993;32:13624-13635.
49. Pomerantz KB, Hajjar DP. Eicosanoid metabolism in cholesterol-enriched arterial smooth muscle cells: reduced arachidonate release with concomitant decrease in cyclooxygenase products. J Lipid Res 1989;30: 1219-1231.
50. Lieber CS. Pathogenesis and early diagnosis of alcoholic liver injury. N Engl J Med 1978;298:888-893.
51. Thomson AD. Alcoholic hepatitis [Editorial]. Lancet 1994;343:810.
52. Burt AD. Cellular and molecular aspects of hepatic fibrogenesis. J Pathol 1993;170:105-114.
53. Simonsen K, Horn T, Mortensen A, Hansen BF, Hansen JF. Liver fibrosis in heterozygous WHHL rabbits fed cholesterol and fats: a new animal model. Int Hepatol Commun 1995;3:310-315.
54. Buyssens N, Kocky MM, Herman AG, Lazou JM, Van den Berg K, Wisse E, Geerts A. Centrolobular liver fibrosis in the hypercholesterolemic rabbit. HEPATOLOGY 1996;24:939-946.
55. Wanless IR, Belgiorno J, Huet PM. Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 1. Morphology and inhibition of fibrogenesis by dipyridamole. HEPATOLOGY 1996;24:855-864.
56. Pesek-Diamond I, Ding G, Frye J, Diamond JR. Macrophages mediate adverse effects of cholesterol feeding in experimental nephrosis. Am J Physiol 1992;263:F776-F783.
57. Moorehead JF. Lipids and progressive kidney disease. Kidney Int 1991; 39(suppl 3):S35-S40.
58. Ding G, Pesek-Diamond I, Diamond JR. Cholesterol, macrophages and gene expression of TGF-β1 and fibronectin during nephrosis. Am J Physiol 1993;264:F577-F584.