Energy preserving effect of l-cis diltiazem in isolated ischemic and reperfused guinea pig hearts: A 31P-NMR study

Japanese Journal of Pharmacology

Volumn 83, Issue 3, 2000, Pages 225-232

  Sakamoto, K ^a   Ishikawa, M ^a   Koga, K ^a   Urushidani, T ^a   Nagao, T ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Ischemia; l cis diltiazem; Nifedipine; Reperfusion

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; DILTIAZEM; DILTIAZEM DERIVATIVE; NIFEDIPINE;

ANIMAL DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG EFFECT; ENERGY METABOLISM; HEART LEFT VENTRICLE PRESSURE; HEART PROTECTION; ISCHEMIA; ISOLATED HEART; NONHUMAN; REPERFUSION; SWINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; GUINEA PIGS; HEART; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; NIFEDIPINE; PHOSPHOCREATINE; PHOSPHORUS ISOTOPES;

EID: 0033865856     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.83.225     Document Type: Article

References (16)

1. 3H] PN200-110 to rabbit T-tubule calcium channels
2. Studies on a new 1,5-benzothiazepine derivative (CRD-401). III. Effects of optical isomers of CRD-401 on smooth muscle and other pharmacological properties
3. Both d-cis- and l-cis-diltiazem have anti-ischemic action in the isolated, perfused working rat heart
4. The mechanism of protective effect of diltiazem on reperfusion-induced arrhythmias in isolated rat heart
5. + accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts
6. + in ischemic guinea-pig heart
7. Effects of glibenclamide and nicorandil on cardiac function during ischemia and reperfusion in isolated perfused rat hearts
8. Mechanisms of ischemic myocardial damage assessed by phosphorus-31 nuclear magnetic resonance
9. Dilitiazem inhibits the late rise extracellular potassium by maintaining glycolytic ATP synthesis during myocardial ischemia
10. Generation of protons by metabolic processes in heart cells
11. Effect of diltiazem on electrical and mechanical activity of isolated cardiac ventricular muscle of guinea pig
12. Protective effect of 1-cis-diltiazem on hypercontracture of rat myocytes induced by veratridine
13. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium and L-cis-diltiazem
14. Cyclic nucleotide-gated ion channels: An extended family with diverse functions
15. 31P-NMR in the isolated perfused rat heart
16. 2+ channel antagonists, DTZ323, on guinea-pig ventricular myocytes