Diltiazem inhibits the late increase in extracellular potassium by maintaining glycolytic ATP synthesis during myocardial ischemia

Journal of Cardiovascular Pharmacology

Volumn 30, Issue 4, 1997, Pages 424-430

  Sakamoto, Kenji ^a   Yamazaki, Jun ^a   Nagao, Taku ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Diltiazem; Extracellular pH; Extracellular potassium; Glycolysis; Guinea pig heart; Iodoacetate

Indexed keywords

ADENOSINE TRIPHOSPHATE; DILTIAZEM; IODOACETIC ACID; LACTIC ACID; POTASSIUM ION;

ANGINA PECTORIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PH; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; GLYCOLYSIS; GUINEA PIG; HEART MUSCLE ISCHEMIA; HYPERKALEMIA; MALE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; EXTRACELLULAR SPACE; GLYCOLYSIS; GUINEA PIGS; HEART FUNCTION TESTS; HYDROGEN-ION CONCENTRATION; MALE; MYOCARDIAL ISCHEMIA; POTASSIUM;

EID: 0030666716     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199710000-00004     Document Type: Article

References (28)

1. Thale J, Gulker H, Olbing B, Rose D, Bender F. Antiarrhythmic and antifibrillatory action of diltiazem on early and late phase ventricular arrhythmias following coronary artery occlusion and on reperfusion ventricular arrhythmias. Pharmacology 1986;33:1-13.
2. Weiss J, Shine KI. Extracellular potassium accumulation during myocardial ischemia: implications for arrhythmogenesis. J Mol Cell Cardiol 1981;13:699-704.
3. Coronet R, Holet JWT, Wilms-Schopman FJG, Schapherder AFM, Johnson TA, Certes LS. Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart Citutlation 1988;77: 1125-38.
4. Wilde AAM, Escande D, Schumacher ÇA, et al. Potassium accumulation in the globally ischémie mammalian heart. Circ Res 1990; 67:835-43.
5. Mitani A, Kinoshita K, Fukamachi K, et al. Effect of glibenclamide and nicorandil on cardiac function during ischemia and reperfusion in isolated perfused rat heart. Am J Physiol 1991;261 (Heart Circ Physiol 30):H 1864-71.
6. e changes during ischemia in rat heart. Am J Physiol 1992;263(Heart Circ Physiol 32):H333-40.
7. Mitani A, Kinoshita K, Fukamachi K, et al. Effects of diltiazem and noradrenaline on extracellular potassium changes in the globally ischémie rat heart. Cardiovasc Res 1992;26:1040-5.
8. Sato R, Yamazaki J, Sakamoto K, Nagao T. Differential effects of nifedipine, verapamil and diltiazem on extracellular potassium and pH during global ischemia in isolated guinea-pig hearts [Abstract]. Jpn J Pharmacol 1994;64(suppl I):260P.
9. Heijnis JB, Coronel R, van Zwieten PA. The effects of calcium antagonists on extracellular potassium accumulation during global ischemia in isolated perfused rat hearts. Cardiovasc Drugs Ther 1991:5:1035-41.
10. Bricknell OL, Daries PS, Opie LH. A relationship between adenosine triphosphate, glycolysis and ischemic contracture in the isolated rat heart. J Mol Cell Cardiol 1981:13:941-5.
11. Ichihara K, Abiko Y. Effect of diltiazem, a calcium antagonist, on myocardial pH in ischemic heart. J Pharmacol Exp Ther 1982; 222: 720-5.
12. Toit EF, Opie LH. Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at onset of reperfusion. Circ Res 1992;70:960-7.
13. Hill JL, Dettes LS, Lynch MR, Hebert NC. Flexible valinomycin electrodes for on-line determination of intravascular and myocardial K+. Am J Physiol 1978;235(Heart Circ Physiol 4):H455-9.
14. + ion-selective electrodes. Am J Physiol 1990;258(Heart Circ Physiol 27):H 1224-31.
15. Nasa Y, Ichihara K, Abiko Y. Both d-cis- and l-cis-diltiazem have anti-ischemic action in the isolated, perfused working rat heart. J Pharmacol Exp Ther 1990;255:680-9.
16. + channels: evidence for preferential regulation by glycolysis. J Gen Physiol 1989;94:911-35.
17. Sellevold OFM, Jynge P, Aarstad K. High performance liquid chromatography: a rapid isocratic method for determination of creatine compounds and adenine nucleotides in myocardial tissue. J Mol Cell Cardiol 1986; 18:517-27.
18. Holzer H, Söing H. Determination with lactic dehydrogenase and the 3-acetylpyridine analogue of DPN (AP-DPN). In: Bergmeyer HV, ed Methods of emyinatic analysis. New York: Academic Press, 1974: 275-7.
19. Kingsley PB, Sako EY, Yang MQ, et al. Ischémie contracture begins when anaerobic glycolysis stops: a 31P-NMR study of isolated rat hearts. Am J Physiol 1991 ;261 (Heart Circ Physiol 30):H469-78.
20. 31P-NMR study. Biochim Biophys Acta 1982;720:17-27.
21. Watts JA, Morris TA, London RE, Steenbergen C, Murphy E. Effects of diltiazem on lactate, ATP and cytosolic free calcium levels in ischémie hearts. J Cardiovasc Phannacol 1990;15:44-9.
22. Lopaschuk GD, Barr R, Wambolt R. Effects of diltiazem on glycolysis and oxidative metabolism in the ischemic/reperfused heart. J Phannacol Exp Tiier 1991;260:1220-8.
23. Ichihara K, Sakai K, Abiko Y. Effect of nifedipine and niludipine on myocardial pH in the ischémie canine heart. Arch Int Pharmacodyn 1986;280:58-73.
24. Ro YM, Markle DR, Goldstein SR, et al. Contrasting effects of verapamil and nifedipine on pH of ischémie myocardium in the dog. J Phannacol Exp Ther 1989;248;654-60.
25. Okuyama R, Adachi-Akahane S, Nagao T. Differential potentiation by depolarization of the effects of calcium antagonists on contraction and Ca2+ current in guinea-pig heart. BrJ Phannacol 1994; 113:451-6.
26. Weishaar R, Ashikawa K, Bing RJ. Effect of diltiazem, a calcium antagonist, on myocardial ischemia. Am J Cardiol 1979;43: 1137-43.
27. Cross HR, Opie LH, Radda GK, Clarke K. Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved. Circ Res 1996;78:482-91.
28. + pump of cardiac Purkinje cells is preferentially fuelled by glycolytic ATP production. Pflugers Arch 1993;422:380-5.