Induced genome instability as a potential screening test for cancer susceptibility?

Medical Hypotheses

Volumn 55, Issue 1, 2000, Pages 69-72

  Shadan, F F ^a   Koziol, J ^b  

^a SCRIPPS CLINIC   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; MUTAGENIC AGENT;

ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER GENETICS; CANCER SCREENING; CANCER SUSCEPTIBILITY; FAMILIAL CANCER; GENE MUTATION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; INTESTINE CANCER; LUNG TUMOR; PENETRANCE; PRIORITY JOURNAL; SKIN CARCINOGENESIS;

EID: 0033865818     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1999.1027     Document Type: Article

References (46)

1. Caldas C., Ponder B. A. J. Cancer genes and molecular oncology in the clinic. Lancet. 349:1997;16.
2. Fearon E. R. Human cancer syndromes: clues to the origin and nature of cancer. Science. 278:1997;1043.
3. Spitz M. R., Hsu T. C., Wu X., Fueger J. J., Amos C. I., Roth J. A. Mutagen sensitivity as a biological marker of lung cancer risk in African Americans. Cancer Epidemiol Biomarkers Prev. 4:1995;99.
4. Spivack S. D., Fasco M. J., Walker V. E., Kaminsky L. S. The molecular epidemiology of lung cancer. Crit Rev Toxicol. 27:1997;319.
5. Sekido Y., Fong K. M., Minna J. D. Progress in understanding the molecular pathogenesis of human lung cancer. Biochim Biophys Acta. 1378:1998;F21.
6. Noreed S. A. Host susceptibility to cancer progression. Am J Hum Genet. 63:1993;1.
7. Rebbeck T. R. Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 6:1997;733.
8. Guo J., Wan D., Zeng R., Zhang Q. The polymorphism of GSTM1, mutagen sensitivity in colon cancer and healthy control. Mutat Res. 372:1996;17.
9. Hsu T. C., Johnston D. A., Cherry L. M. Sensitivity to genotoxic effects of bleomycin in humans: Possible relationship to environmental carcinogenesis. Int J Cancer. 43:1989;403.
10. Schantz S. P., Hsu T. C. Mutagen-induced chromosome fragility within peripheral blood lymphocytes of head and neck cancer patients. Head Neck. June/July:1989;337.
11. Spitz, M. R. Fueger, J. J. Beddingfield, N. A. Chromosome sensitivity to bleomycin-induced mutagenesis, an independent risk factor for upper aerodigestive tract cancers. 1989, Cancer Res, 1989, 49, 4626.
12. Cloos J., Braakhuis B. J. M., Steen I. Increased mutagen sensitivity in head-and-neck squamous cell carcinoma patients, particularly those with multiple primary tumors. Int J Cancer. 56:1994;816.
13. Cloos J., Spitz M. R., Schantz S. P. Genetic susceptibility to head and neck squamous cell carcinoma. J Natl Cancer Inst. 88:1996;530.
14. Ko J. Y., Lui L. T., Sheen T. S., Lou P. J., Hsu M. M. Increased mutagen sensitivity in patients with head and neck cancer is less pronounced in patients with nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 124:1998;578.
15. Spitz M. R., Fueger J. J., Halabi S., Schantz S. P., Sample D., Hsu T. C. Mutagen sensitivity in upper aerodigestive tract cancer: A case-control Analysis. Cancer Epidemiol Biomarkers Prev. 2:1993;329.
16. Schantz S. P., Zhang Z. F., Spitz M. S., Sun M., Hsu T. C. Genetic susceptibility to head and neck cancer: Interaction between nutrition and mutagen sensitivity. Laryngoscope. 107:1997;765.
17. Schantz S. P., Spitz M. R., Hsu T. C. Mutagen sensitivity in patients with head and neck cancers: A biological marker for risk of multiple primary malignancies. J Natl Cancer Inst. 82:1990;1773.
18. Spitz M. R., Hoque A., Trizna Z. Mutagen sensitivity as a risk factor for second malignant tumors following malignancies of the upper aerodigestive tract. J Natl Cancer Inst. 86:1994;1681.
19. Spitz M. R., Lippman S. M., Hong J. Mutagen sensitivity as a predictor of tumor recurrence in patients with cancer of the upper aerodigestive tract. J Natl Cancer Inst. 90:1998;243.
20. Wu X., Delclos G. L., Annegers J. F. A case-control study of wood dust exposure, mutagen sensitivity, and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 4:1995;583.
21. Bondy M. L., Kyritsis A. P., Gu J. Mutagen sensitivity and risk of gliomas: a case-control analysis. Cancer Res. 56:1996;1484.
22. Knight R. D., Parshad R., Price F. M., Tarone R. E., Sanford K. K. X-ray-induced chromatid damage in relation to DNA repair and cancer incidence in family members. Int J Cancer. 54:1993;589.
23. Helzlsouer K. J., Harris E. L., Parshad R., Perry H. R., Price F. M. DNA repair proficiency: Potential susceptibility factor for breast cancer. J Natl Cancer Inst. 2:1996;329.
24. 2phase X-irradiation of cells from retinoblastoma patients. Cancer Genet Cytogenet. 88:1996;43.
25. 2chromatin radiosensitivity in predisposition to cancer. Int J Radiat Biol. 55:1989;963.
26. Parshad R., Price F. M., Bohr V. A., Cowans K. H., Zujewski J. A., Sanford K. K. Deficient DNA repair capacity, a predisposing factor in breast cancer. Br J Cancer. 74:1996;1.
27. Au W. W., Wilkinson G. S., Tyring S. K. Monitoring populations for DNA repair deficiency and for cancer susceptibility. Environ Hlth Perspect. 104:1996;579.
28. Wu X., Gu J., Patt Y., Hassan M., Spitz M. R., Beasely R. P., Hwang L. Y. Mutagen sensitivity as a susceptibility marker for human hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev. 7:1998;567.
29. Dave B. J., Hopwood V. L., King T. M., Ziang H., Spitz M. R., Pathak S. Genetic susceptibility to lung cancer as determined by lymphocytic chromosome analysis. Cancer Epidemiol Biomarkers Prev. 4:1995;743.
30. Ankathil R., Bhattathiri N. V., Francis J. V. Mutagen sensitivity as a predisposing factor in familial oral cancer. Int J Cancer. 69:1996;265.
31. Miller D. G., Tiwari R., Pathak S., Hopwood V. L., Gilbert F., Hsu T. C. DNA repair and mutagen sensitivity in patients with triple primary cancers. Cancer Epidemiol Biomarkers Prev. 7:1998;321.
32. Bondy M. L., Spitz M. R., Halabi S. Association between family history of cancer and mutagen sensitivity in upper aerodigestive tract cancer patients. Cancer Epidemiol Biomarkers Prev. 2:1993;103.
33. Pandita T. K., Hittelman W. N. Evidence of a chromatin basis for increased mutagen sensitivity associated with multiple primary malignancies of the head and neck. Int J Cancer. 61:1995;738.
34. Trivedi A. H., Bakshi S. R., Jaju R. J. Elevated mutagen susceptibility in cultured lymphocytes of oral cancer patients. Anticancer Res. 15:1995;2589.
35. Bakshi S. R., Patel R. K., Roy S. K. Mitomycin C induced chromosomal aberrations in young cancer patients. Mutat Res. 422:1998;223.
36. Parshad R., Sanford K. K., Jones G. M. Chromatid damage induced by fluorescent light during G2 phase in normal and Gardner syndrome fibroblasts. Interpretation in terms of deficient DNA repair. Mutat Res. 151:1985;57.
37. Sanford K. K., Price F. M., Brodeur C., Makrauer F. L., Parshad R. Deficient DNA repair in chronic ulcerative colitis. Cancer Detect Prev. 21:1997;540.
38. Helzlsouer K. J., Harris E. L., Parshad R., Fogel S., Bigbee W. L., Sanford K. K. Familial clustering of breast cancer: Possible interaction between DNA repair proficiency and radiation exposure in the development of breast cancer. Int J Cancer. 64:1995;14.
39. Liang J. C., Pinkel D. P., Bailey N. M., Trujillo J. M. Mutagen sensitivity and cancer susceptibility. Cancer. 64:1989;1474.
40. Kovacs E., Langemann H. Defective DNA repair in a large family having a high occurrence of cancer. Oncology. 45:1988;444.
41. Wei Q., Spitz M. R., Gu J. DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines. Cancer Epidemiol Biomarkers Prev. 5:1996;199.
42. Sanford K. K., Parshad R., Price F. M., Tarone R. E., Thompson J., Guerry D. Radiation-induced chromatid breaks and DNA repair in blood lymphocytes of patients with dysplastic nevi and/or cutaneous melanoma. J Invest Dermatol. 109:1997;546.
43. Wu X., Hsu T. C., Spitz M. R. Mutagen sensitivity exhibits a dose-dependent relationship in case-control studies. Cancer Epidemiol Biomarkers Prev. 5:1996;577.
44. Shadan F. F., Villarreal L. P. Potential role of DNA polymerase beta in gene therapy against cancer: A case for colorectal cancer. Med Hypotheses. 47:1996;1.
45. Shadan F. F. Parvovirus-mediated antineoplastic activity exploits genome instability. Med Hypotheses. 2000.
46. Fleiss J. L. The statistical basis of meta-analysis. Statist Meth Med Res. 2:1993;121.