Thalidomide analogue CC-3052 reduces HIV + neutrophil apoptosis in vitro

Clinical and Experimental Immunology

Volumn 121, Issue 3, 2000, Pages 472-479

  Guckian, M ^a   Dransfield, I ^a,c   Hay, P ^a,b   Dalgleish, A G ^a  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b Department of Genito Urinary Medicine ^*  (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Apoptosis; CAMP; HIV; Neutrophils; Thalidomide

Indexed keywords

ADENYLATE CYCLASE ACTIVATOR; CC 3052; CD16 ANTIGEN; LIPOCORTIN 5; PROSTAGLANDIN E; PROSTAGLANDIN E2; THALIDOMIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL CULTURE; CELL VIABILITY; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOMODULATION; MALE; NEUTROPHIL; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ADULT; APOPTOSIS; CYCLIC AMP; DINOPROSTONE; DRUG SYNERGISM; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; NEUTROPHILS; THALIDOMIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033864872     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01332.x     Document Type: Article

References (49)

1. Cytokines and HIV infection: Is AIDS a tumor necrosis factor disease?
2. + infected individuals is mediated by FasL and tumor necrosis factor
3. Membrane TNF induced cooperative signaling of TNFR60 and TNFR80 favors induction of cell death rather than virus production in HIV-infected T cells
4. CD4 Regulates susceptibility to Fas ligand and tumor necrosis factor-mediated apoptosis
5. Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection
6. The effect of thalidomide on the pathogenesis of human immunodeficiency virus Type 1 and M. tuberculosis infection
7. Effects of thalidomide on HIV-associated wasting syndrome: A randomised, double blind, placebo-controlled clinical trial
8. Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes
9. Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro
10. Selection of novel analogs of thalidomide with enhanced tumor necrosis factor α inhibitory activity
11. Structural modifications of thalidomide produce analogues with enhanced tumor necrosis factor inhibitory activity
12. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha
13. CC-3052: A non-toxic water soluble analogue of thalidomide and potent suppressor of activation-induced TNFα production
14. Up-regulation of monocytic IL-10 by tumor necrosis factor α and cAMP elevating drugs
15. Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kB-mediated transcription
16. The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response
17. Neutropenia is associated with bacteremia in patients infected with the human immunodeficiency virus
18. Neutropenia in allogeneic marrow transplant recipients receiving Ganciclovir for prevention of cytomegalovirus disease: Risk factors and outcome
19. Neutropenia and bacterial infection in acquired immunodeficiency syndrome
20. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
21. Neutrophil apoptosis is associated with a reduction in CDI6 (FcγRIII) expression
22. Glucocorticoids inhibit apoptosis of human neutrophils
23. Glucocorticoid treatment inhibits apoptosis in human neutrophils: Separation of survival and activation outcomes
24. Agents that elevate cAMP inhibit human neutrophil apoptosis
25. Effect of Pentoxifylline on apoptosis of cultured cells
26. Effect of thalidomide on apoptosis of lymphocytes and neutrophils
27. Plasma pharmokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers
28. Human neutrophils lose their surface FcγRIII and acquire annexin V binding sites during apoptosis in vivo
29. Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome
30. Regulation of neutrophil apoptosis by TNFα: Requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro
31. Tailored cAMP-signalling responses through isoform multiplicity
32. Neutrophils isolated from leprosy patients release TNF-alpha and exhibit accelerated apoptosis in vitro
33. Effects of tumor necrosis factor and pentoxifylline on ICAM-1 expression on human polymorphonuclear granulocytes
34. Phosphodiesterase (PDE) 4 inhibitors: Anti-inflammatory drugs of the future?
35. Possible risk of steroid administration in patients at risk for AIDS
36. T-cell receptor-independent apoptosis of thymic clones induced by a thymic epithelial cell line is mediated by steroids
37. Identification of a novel glucocorticoid response element within the genome of the human immunodeficiency virus type 1
38. Interleukin-10 counter-regulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis
39. Rapid acceleration of neutrophil apoptosis by TNF-α
40. In vivo regulation of rat neutrophil apoptosis occurring spontaneously or induced with TNF-α or cycloheximide
41. NF-kappa B activation is a critical regulator of human granulocyte apoptosis in vitro
42. Regulation of macrophage phagocytosis of apoptotic cells by cAMP
43. Type I cAMP-dependent kinase delays apoptosis in human neutrophils at a site upstream of caspase-3
44. Altered production of PGE2, IL-1beta and TNF-alpha by peripheral blood monocytes from HIV-positive individuals at early stages of HIV infection
45. Abnormal intracellular IL-2 and interferon-gamma (IFN-γ) production as HIV-1-associated markers of immune dysfunction
46. Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells
47. Interferon-γ and tumor necrosis factor-α specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines
48. Selective down-regulation of T cell- and non-T cell derived tumor necrosis factor α by thalidomide: Comparisons with dexamethasone
49. Thalidomide and derivatives: Immunological investigations of tumor necrosis factor-alpha (TNFα) inhibition suggest drugs capable of selective gene regulation