Detection and quantification of CD4+ t cells with specificity for a new major histocompatibility complex class II-restricted influenza A virus matrix protein epitope in peripheral blood of influenza patients

Journal of Virology

Volumn 74, Issue 18, 2000, Pages 8740-8743

  Linnemann, T ^a   Jung, G ^a   Walden, P ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MATRIX PROTEIN; VIRUS PROTEIN;

ALLELE; ANTIGEN PRESENTATION; ARTICLE; HAPLOTYPE; HLA SYSTEM; HUMAN; HUMAN CELL; INFLUENZA; INFLUENZA VIRUS; LYMPHOCYTE CLONE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION;

AMINO ACID SEQUENCE; AMINO ACIDS; CD4-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; GENES, MHC CLASS II; HAPLOTYPES; HLA-DR4 ANTIGEN; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; VIRAL MATRIX PROTEINS;

EID: 0033863520     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.18.8740-8743.2000     Document Type: Article

References (29)

1. Identification of overlapping epitopes in mutant ras oncogene peptides that activate CD4+ and CD8+ T cell responses
2. Phenotypic analysis of antigen-specific T lymphocytes
3. Antigen presentation: Structural themes and functional variations
4. Class II-restricted presentation of a hen egg lysozyme determinant derived from endogenous antigen sequestered in the cytoplasm or endoplasmic reticulum of the antigen presenting cells
5. Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo
6. Overlapping epitopes that are recognized by CD8+ HLA class I-restricted and CD4+ class II-restricted cytotoxic T lymphocytes are contained within an influenza nucleoprotein peptide
7. Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood
8. Analysis of a naturally occurring HLA class I-restricted viral epitope
9. Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART)
10. Presentation of a cytosolic antigen by major histocompatibility complex class II molecules requires a long-lived form of the antigen
11. Class II MHC-restricted T cell determinants processed from either endosomes or the cytosol show similar requirements for host protein transport but different kinetics of presentation
12. Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers
13. An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells
14. T-cell epitope mapping by flow cytometry
15. Two populations of Ia-like molecules on a human B cell line
16. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
17. Invariant chain prevents the HLA-DR-restricted presentation of a cytosolic peptide
18. Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells
19. Cytotoxic T lymphocytes specific for influenza virus
20. + T cells proliferating in response to influenza A antigen
21. Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system
22. Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen
23. Antigen presentation mediated by recycling of surface HLA-DR molecules
24. HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
25. MHC ligands and peptide motifs
26. An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type i induces CD4 class II-restricted help for itself
27. A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers
28. Normal human CD4+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis
29. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency