Allelic diversity of the two transferrin binding protein B gene isotypes among a collection of Neisseria meningitidis strains representative of serogroup B disease: Implication for the composition of a recombinant TbpB-based vaccine

Infection and Immunity

Volumn 68, Issue 9, 2000, Pages 4938-4947

  Rokbi, B ^a   Renauld Mongenie, G ^a   Mignon, M ^a   Danve, B ^a   Poncet, D ^a   Chabanel, C ^a   Caugant, D A ^a   Quentin Millet, M J ^a  

^a SANOFI PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; RECOMBINANT VACCINE; TRANSFERRIN;

ALLELE; ANTIBODY PRODUCTION; ARTICLE; BACTERICIDAL ACTIVITY; GENE SEQUENCE; MENINGOCOCCOSIS; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VACCINATION;

ALLELES; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; BASE SEQUENCE; BLOOD BACTERICIDAL ACTIVITY; CARRIER PROTEINS; IMMUNE SERA; IRON-BINDING PROTEINS; MICE; NEISSERIA MENINGITIDIS; PHYLOGENY; RABBITS; RECOMBINANT PROTEINS; TRANSFERRIN-BINDING PROTEIN B; TRANSFERRIN-BINDING PROTEINS; VACCINES, SYNTHETIC; VARIATION (GENETICS);

EID: 0033863076     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.9.4938-4947.2000     Document Type: Article

References (46)

1. The meningococcal transferrin-binding proteins 1 and 2 are both surface exposed and generate bactericidal antibodies capable of killing homologous and heterologous strains
2. Localization of the meningococcal receptors for human transferrin
3. Immune responses in humans and animals to meningococcal transferrin-binding proteins: Implications for vaccine design
4. Transferrin binding protein two interacts with both the N-lobe and C-lobe of ovotransferrin
5. Purified meningococcal transferrin-binding protein B interacts with a secondary, strain-specific, binding site in the N-terminal lobe of human transferrin
6. Human antibody responses to A and C capsular polysaccharides, IgA1 protease and transferrin-binding protein complex stimulated by infection with Neisseria meningitidis of subgroup IV-1 or ET-37 complex
7. Population genetics and molecular epidemiology of Neisseria meningitidis
8. Multilocus genotypes determined by enzyme electrophoresis of Neisseria meningitidis isolated from patients with systemic disease
9. Genetic structure of Neisseria meningitidis populations in relation to serogroup, serotype, and outer membrane protein pattern
10. Transferrin-binding proteins isolated from Neisseria meningitidis elicit protective and bactericidal antibodies in laboratory animals
11. In vivo human immune response to transferrin-binding protein 2 and other iron-regulated proteins of Neisseria meningitidis
12. Immunogenicity and antigenic heterogeneity of a human transferrin-binding protein in Neisseria meningitidis
13. Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis
14. Human immunity to the meningococcus. II. Development of natural immunity
15. Effect of adjuvants in the isotypes and bactericidal activity of antibodies against the transferrin-binding proteins of Neisseria meningitidis
16. Human antibody response to meningococcal transferrin binding proteins: Evidence for vaccine potential
17. Antigenic and molecular heterogeneity of the transferrin-binding protein of Neisseria meningitidis
18. Recombinational reassortment among opa genes from ET-37 complex Neisseria meningitidis isolates of diverse geographical origins
19. Analysis of the human Ig isotype response to individual transferrin binding proteins A and B from Neisseda meningitidis
20. Molecular characterization of hybrid Tbp2 proteins from Neisseria meningitidis
21. Cloning and characterization of Neisseria meningitidis genes encoding the transferrin-binding proteins Tbp1 and Tbp2
22. Characterization of genetic exchanges between various highly divergent tbpBs having occurred in Neisseria meningitidis
23. Human opsonins induced during meningococcal disease recognize transferrin binding protein complexes
24. Evaluation of transferrin-binding protein 2 within the transferrin-binding protein complex as a potential antigen for future meningococcal vaccines
25. Cloning and expression of the Haemophilus influenzae transferrin receptor genes
26. A global gene pool in the neisseriae
27. Diversity of the transferrin-binding protein Tbp2 of Neisseria meningitidis
28. Clonal descent and microevolution of Neisseria meningitidis during 30 years of epidemic spread
29. The transferrin binding protein B of Moraxella catarrhalis elicits bactericidal antibodies and is a potential vaccine antigen
30. Clonal population structure of Neisseria meningitidis serogroup A isolated from epidemics and pandemics between 1915 and 1983
31. Meningococcal disease: Still with us
32. Rapid extraction of bacterial genomic DNA with guanidium thiocyanate
33. Outer membrane protein serosubtyping of Neisseria meningitidis
34. Protective capacity of the Pasteurella haemolytica transferrin-binding proteins TbpA and TbpB in cattle
35. Both the full-length and the N-terminal domain of the meningococcal transferrin-binding protein B discriminate between human iron-loaded and apo-transferrin
36. Identification of human transferrin-binding sites within meningococcal transferrin-binding protein B
37. Identification of sequences in human transferrin that bind to the bacterial receptor protein, transferrin-binding protein B
38. Identification of two major families of transferrin receptors among Neisseria meningitidis strains based on antigenic and genomic features
39. Heterogeneity of tbpB, the transferrin-binding protein B gene, among sero-group B Neisseria meningitidis strains of the ET-5 complex
40. Evaluation of recombinant transferrin-binding protein B variants from Neisseria meningitidis for their ability to induce cross-reactive and bactericidal antibodies against a genetically diverse collection of serogroup B strains
41. Immunization of pigs against Actinobacillus pleuropneumoniae with two recombinant protein preparations
42. The neighbor-joining method: A new method for reconstructing phylogenetic trees
43. Identification and characterization of the transferrin receptor from Neisseria meningitidis
44. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
45. Antigenic and epidemiologic properties of the ET-37 complex of Neisseria meningitidis
46. Emergence of a new virulent done within the electrophoretic type 5 complex of serogroup B meningococci in Norway