Identification of human transferrin-binding sites within meningococcal transferrin-binding protein B

Journal of Bacteriology

Volumn 179, Issue 20, 1997, Pages 6400-6407

  Renauld Mongénie, Geneviève ^a   Poncet, David ^a   Von Olleschik Elbheim, Lars ^b   Cournez, Thierry ^a   Mignon, Michèle ^a   Schmidt, M Alexander ^b   Quentin Millet, Marie José ^a  

^a Pasteur Merieux Connaught   (France)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFERRIN RECEPTOR;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DRUG RECEPTOR BINDING; ENZYME SPECIFICITY; GENETIC RECOMBINATION; IRON TRANSPORT; LIGAND BINDING; NEISSERIA MENINGITIDIS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSLATION REGULATION;

EID: 0030753236     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.20.6400-6407.1997     Document Type: Article

References (43)

1. Ala'Aldeen, D. A. A., and S. P. Borriello. 1996. The meningococcal transferrin-binding proteins 1 and 2 are both surface exposed and generate bactericidal antibodies capable of killing homologous and heterologous strains. Vaccine 14:49-53.
2. Ala'Aldeen, D. A. A., N. B. L. Powell, R. A. Wall, and S. P. Borriello. 1993. Localization of the meningococcal receptors for human transferrin. Infect. Immun. 61:751-759.
3. Alcantara, J., and A. B. Schryvers. 1996. Transferrin-binding protein two interacts with both the N-lobe and C-lobe of ovotransferrin. Microb. Pathog. 20:73-85.
4. Alcantara, J., R.-H. Yu, and A. B. Schryvers. 1993. The region of human transferrin involved in binding to bacterial transferrin receptors is localized in the C-lobe. Mol. Microbiol. 8:1135-1143.
5. Anderson, J. E., P. F. Sparling, and C. N. Cornelissen. 1994. Gonococcal transferrin-binding protein 2 facilitates but is not essential for transferrin utilization. J. Bacteriol. 176:3162-3170.
6. Archibald, F. S., and I. W. DeVoe. 1979. Removal of iron from human transferrin by Neisseria meningitidis. FEMS Microbiol. Lett. 6:159-162.
7. Archibald, F. S., and I. W. DeVoe. 1980. Iron acquisition by Neisseria meningitidis in vitro. Infect. Immun. 27:322-334.
8. Baker, E. N., S. V. Rumball, and B. F. Anderson. 1987. Transferrins: insights into structure and function from studies on lactoferrin. Trends Biochem. Sci. 12:350-355.
9. Cornelissen, C. N., and P. F. Sparling. 1996. Binding and surface exposure characteristics of the gonococcal transferrin receptor are dependent on both transferrin-binding proteins. J. Bacteriol. 178:1437-1444.
10. Cornelissen, C. N., J. E. Anderson, and P. F. Sparling. 1997. Characterization of the diversity and the transferrin-binding domain of gonococcal transferrin-binding protein 2. Infect. Immun. 65:822-828.
11. Danve, B., L. Lissolo, M. Mignon, P. Dumas, S. Colombani, A. B. Schryvers, and M.-J. Quentin-Millet. 1993. Transferrin-binding proteins isolated from Neisseria meningitidis elicit protective and bactericidal antibodies in laboratory animals. Vaccine 11:1214-1220.
12. Dupuy, M. Unpublished data.
13. Frank, R. 1992. Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron 48:9217-9232.
14. Fuller, C. A., M. D. Retzer, E. Jacobs, and A. B. Schryvers. 1996. Evidence for a bi-lobed structure for meningococcal transferrin-binding protein B, p. 572-573. In Abstracts of the Tenth International Pathogenic Neisseria Conference 1996.
15. Gerlach, G.-F., S. Klashinsky, C. Anderson, A. A. Potter, and P. J. Willson. 1992. Characterization of two genes encoding distinct transferrin-binding proteins in different Actinobacillus pleuropneumoniae isolates. Infect. Immun. 60:3253-3261.
16. Gray-Owen, S. D., S. M. Loosmore, and A. B. Schryvers. 1995. Identification and characterization of genes encoding the human transferrin-binding proteins from Haemophilus influenzae. Infect. Immun. 63:1201-1210.
17. Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488-492.
18. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
19. Lee, B. C., and P. Hill. 1992. Identification of an outer membrane haemoglobin-binding protein in Neisseria meningitidis. J. Gen. Microbiol. 138:2647-2656.
20. Legrain, M., A. Findeli, D. Villeval, M.-J. Quentin-Millet, and E. Jacobs. 1996. Molecular characterization of hybrid Tbp2 proteins from Neisseria meningitidis. Mol. Microbiol. 19:159-169.
21. Legrain, M., V. Mazarin, S. W. Irwin, B. Bouchon, M.-J. Quentin-Millet, E. Jacobs, and A. B. Schryvers. 1993. Cloning and characterization of Neisseria meningitidis genes encoding the transferrin-binding proteins Tbp1 and Tbp2. Gene 130:73-80.
22. Lewis, L. A., and D. W. Dyer. 1995. Identification of an iron-regulated outer membrane protein of Neisseria meningitidis involved in the utilization of hemoglobin complexed to haptoglobin. J. Bacteriol. 177:1299-1306.
23. Lissolo, L., P. Dumas, G. Maître, and M.-J. Quentin-Millet. 1992. Purification and preliminary characterization of transferrin-binding proteins from Neisseria meningitidis, p. 399-405. In Abstracts of the Eighth International Pathogenic Neisseria Conference. Instituto Nacional de Salud Publica, Cuernavaca, Mexico.
24. Mazarin, V., B. Rokbi, and M.-J. Quentin-Millet. 1995. Diversity of the transferrin-binding protein Tbp2 of Neisseria meningitidis. Gene 158:145-146.
25. McGillivray, R. T. A., E. Mendez, J. G. Shewale, S. Sinha, J. Lineback, and K. Brew. 1983. The primary structure of human serum transferrin. J. Biol. Chem. 258:3543-3553.
26. Merrifield, R. B. 1963. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85:2149-2152.
27. Merrifield, R. B. 1986. Solid phase synthesis. Science 232:341-347.
28. Newman, R., C. Schneider, R. Sutherland, L. Vodinelich, and M. Greaves. 1982. The transferrin receptor. Trends Biochem. Sci. 7:397-400.
29. Ogunnariwo, J., C. Cheng, J. Ford, and A. B. Schryvers. 1990. Response of Haemophilus somnus to iron limitation: expression and identification of a bovine-specific transferrin receptor. Microb. Pathog. 9:397-406.
30. Petterson, A., A. Maas, and J. Tommassen. 1994. Identification of the iroA gene product of Neisseria meningitidis as a lactoferrin receptor. J. Bacteriol. 176:1764-1766.
31. Retzer, M. D., A. Kabani, L. L. Button, R.-H. Yu, and A. B. Schryvers. 1996. Production and characterization of chimeric transferrins for determination of the binding domains for bacterial transferrin receptors. J. Biol. Chem. 271:1166-1173.
32. Rokbi, B., M. Mignon, G. Maître-Willmotte, L. Lissolo, B. Danve, D. A. Caugant, and M.-J. Quentin-Millet. 1997. Evaluation of recombinant transferrin-binding protein B variants from Neisseria meningitidis for their ability to induce cross-reactive and bactericidal antibodies against a genetically diverse collection of serogroup B strains. Infect. Immun. 65:55-63.
33. Rokbi, B., G. Maître-Willmotte, V. Mazarin, L. Fourrichon, L. Lissolo, and M.-J. Quentin-Millet. 1995. Variable sequences in a mosaic-like domain of meningococcal tbp2 encode immunoreactive epitopes. FEMS Microbiol. Lett. 132:277-283.
34. Rokbi, B., V. Mazarin, G. Maître-Wilmotte, and M.-J. Quentin-Millet. 1993. Identification of two major families of transferrin receptors among Neisseria meningitidis strains based on antigenic and genomic features. FEMS Microbiol. Lett. 110:51-58.
35. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
36. Schryvers, A. B., and G. C. Gonzalez. 1990. Receptors for transferrin in pathogenic bacteria are specific for host's protein. Can. J. Microbiol. 36:145-147.
37. Schryvers, A. B., and L. J. Morris. 1988. Identification and characterization of the transferrin receptor from Neisseria meningitidis. Mol. Microbiol. 2: 281-288.
38. Strutzberg, K., L. von Olleschik, B. Franz, C. Pyne, M. A. Schmidt, and G.-F. Gerlach. 1995. Mapping of functional regions on the transferrin-binding protein (TfbA) of Actinobacillus pleuropneumoniae. Infect. Immun. 63:3846-3850.
39. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
40. Vonder Haar, R. A., M. Legrain, H. V. J. Kolbe, and E. Jacobs. 1994. Characterization of a highly structured domain in Tbp2 from Neisseria meningitidis involved in binding to human transferrin. J. Bacteriol. 176:6207-6213.
41. von Olleschik-Elbheim, L., A. el Bayâ, and M. A. Schmidt. 1996. Quantification of immunological membrane reactions employing a digital desk top scanner and standard graphics software. J. Immunol. Methods 197:181-186.
42. Williams, J. 1982. The evolution of transferrin. Trends Biochem. Sci. 7:394-397.
43. Zak, O., D. Trinder, and P. Aisen. 1994. Primary receptor-recognition site of human transferrin is in the C-terminal lobe. J. Biol. Chem. 269:7110-7114.