Amelioration of denervation-induced atrophy by clenbuterol is associated with increased PKC-α activity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 279, Issue 1 42-1, 2000, Pages

  Sneddon, A A ^a   Delday, M I ^a   Maltin, C A ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Kinase activity; Skeletal muscle; agonist

Indexed keywords

CLENBUTEROL; PROTEIN KINASE C;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FAST MUSCLE; MUSCLE ATROPHY; MUSCLE DENERVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SOLEUS MUSCLE;

EID: 0033861490     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.279.1.e188     Document Type: Article

References (35)

1. Effect of beta-agonists on expression of calpain and calpastatin activity in skeletal muscle
2. The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate
3. Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway
4. Caspase-3-mediated cleavage of protein kinase C θ in induction of apoptosis
5. Role of protein kinase C in chick embryo skeletal myoblast fusion
6. Expression of the major enzyme of protein kinase C in skeletal muscle, nPKC theta, varies with muscle type and in response to fructose induced insulin resistance
7. Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy
8. Inhibition of expression of protein kinase C alpha by antisense cDNA inhibits phorbol ester-mediated arachidonate release
9. The effects of denervation on protein turnover of rat skeletal muscle
10. Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane
11. Developmental regulation of a protein kinase C isoform localized in the neuromuscular junction
12. Neural influence on protein kinase C isoform expression in skeletal muscle
13. Control of myogenic factor genes by the membrane depolarization/protein kinase C cascade in chick skeletal muscle
14. Protein kinase C couples membrane excitation to acetylcholine receptor gene inactivation in chick skeletal muscle
15. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
16. 2+, phospholipid-dependent protein kinase associated with the plasma membrane
17. Protein kinase C and its substrates
18. The sevenfold way of PKC regulation
19. Clenbuterol mimics effects of innervation on myogenic regulatory factor expression
20. The effect of clenbuterol administration in utero and throughout lactation on pre- and postnatal muscle development in the rat
21. The action of the β-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles
22. Clenbuterol, a beta agonist, induces growth in innervated and denervated rat soleus muscle via apparently different mechanisms
23. Tissue specific responses to clenbuterol: Temporal changes in protein metabolism of striated muscle and visceral tissues from rats
24. Inhibition and reversal of denervation-induced atrophy by the beta-agonist growth promoter, clenbuterol
25. Clenbuterol, a beta 2-adrenergic agonist, reverses muscle wasting due to scald injury in the rat
26. The effect of the beta-adrenergic agonist clenbuterol on growth and protein metabolism in rat muscle cell cultures
27. Catalytic fragment of protein kinase C exhibits altered substrate specificity toward smooth muscle myosin light chain
28. A new member of the protein kinase C family, nPKC θ, predominantly expressed in skeletal muscle
29. Translocation of protein kinase C isoforms in rat muscle in response to fasting and refeeding
30. The energy cost of fat and protein deposition in the rat
31. Stimulation of muscle growth by clenbuterol: Lack of effect on muscle protein biosynthesis
32. The possible involvement of prostaglandin F2 alpha in the stimulation of muscle protein synthesis by insulin
33. Degradation of protein kinase C alpha and its free catalytic subunit, protein kinase M, in intact human neuroblastoma cells and under cell-free conditions. Evidence that PKM is degraded by mM calpain-mediated proteolysis at a faster rate than PKC
34. Arachidonate activation of protein kinase C may be involved in the stimulation of protein synthesis by insulin in L6 myoblasts
35. N(τ)-methylhistidine turnover in skeletal muscle cells measured by GC-MS