Toxicity of bupivacaine and ropivacaine in relation to free plasma concentrations in pregnant rats: A comparative study

Pharmacology and Toxicology

Volumn 81, Issue 2, 1997, Pages 90-96

  Danielsson, Bengt R G ^a   Danielson, M Kiki ^a   Böö, Éva Lindström ^a   Arvidsson, Torbjörn ^a   Halldin, Magnus M ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; ROPIVACAINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CONVULSION; DROWSINESS; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; DYSPNEA; FEMALE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; SALIVATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0030834138     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb00037.x     Document Type: Article

References (29)

1. Albright, G. A: Cardiac arrest following regional anesthesia with etidocaine or bupivacaine (Editorial). Anesthesiologv 1979, 51, 285-287.
2. Arthur, G. R., H. S. Feldman, S. B. Norway, A. M. Doucette & B. G. Covino: Acute intravenous toxicity of LE A103, a new local anesthetic, compared to tidocaine and bupivacaine in the awake dog. Anesthesiology 1986, 65, A182.
3. Arvidsson, T. & E. Eklund: Determination of the free concentration of ropivacaine and bupivacaine in blood plasma by ultrafiltration and coupled-column liquid chromatography. J. Chromatogr. 1995, 668, 91-98.
4. Baum, V. C., D. J. Miletich & M. A. Curran: Progesterone potentiation of bupivacaine arrhythmogenicity in pentobarbital-anesthetized rats and beating rat heart cell cultures. J. Cardiovasc. Pharmacol. 1992, 20, 533-537.
5. Beazley, J. M., G. Taylor & F. Reynolds: Placental transfer of bupivacaine after paracervical block. Obstet. Gynecol. 1972, 39, 2-6.
6. Björk, M., K.,-J. Pettersson & G. Österlöf: Capillary gas Chromatographic method for the simultaneous determination of local anaesthetics in plasma samples. J. Chromatogr. 1990, 533, 229-234.
7. Crandell, J. T. & D. M. Kotelko: Cardiotoxicity of local anesthetics during late pregnancy. Anesth. Analg. 1985, 6, 204.
8. Datta, S., D. H. Lambert, J. Gregus, A. J. Gissen & B. G. Covino: Differential sensitivities of mammalian nerve fibers during pregnancy. Anesth. Analg. 1983, 62, 1070-1072.
9. Datta, S., W. Camann, A. Baden & L. VanderBurgh: Clinical effects and maternal and fetal plasma concentrations of epidural ropivacaine versus bupivacaine for cesarean section. Anesthesiology 1995, 82, 1346-1352.
10. Denson, D. D., J. A. Myers, C. T. Hartrick, C. P. Pitcher, D. E. Coyle & P. P. Raj: The relationship between free bupivacaine concentration and central nervous system toxicity. Anesthesiology 1984, 61, A211.
11. Editorial: Cardiotoxicity of local anaesthetic drugs. Lancet 1986, 2, 1182-1194.
12. Hodgkinson, R: Early and late onset convulsions following regional anesthesia for Cesarean section. Society of Obstetric Anesthesia and Perinatology Annual Meeting 1978, p. 14.
13. Knudsen, K., H. Beckman, S. Blomberg, J. Sjövall & N. Edvardsson: Central nervous and cardiovascular effects during intravenous infusions of ropivacaine, bupivacaine and placebo in healthy volunteers (abstract). XIV Annual ESRA Congress, Prague, International Monitor of Regional Anesthesia, Medicom Europe 1995 (Sept.), p. 15.
14. Morishima, H. O., H. Pedersen, M. Finster, H. Hiraoko, A. Tsuji, H. S. Feldman, G. R. Arthur & B. G. Covino: Bupivacaine toxicity in pregnant and nonpregnant ewes. Anesthesiology 1985, 63, 134-139.
15. Moore, D. C., L. D. Bridenbaugh, P. O. Bridenbaugh & G. T. Tucker: Caudal and epidural blocks with bupivacaine for child-birth: Report of 657 parturients. Obstet. Gynecol. 1971, 37, 667-676.
16. Ravindran, R. S., K. C. Kim & S. J. Baldwin: The effect of pregnancy on the threshold to local anesthetic induced convulsions in mice. Anesthesiology 1982, 57, A400.
17. Reynolds, F.: The fetus and placenta. In: Wylie and Churchill-Davidson's A practice of anaesthesia, 5th ed. Ed.: H.C. Churchill-Davidson. Lloyd-Luke, London, 1984, p. 1069.
18. Reynolds, F.: Adverse effects of local anesthetics. Brit. J. Anaesth. 1987, 59, 78-95.
19. Rosenblatt, D. B., E. M. Belsey, B. A. Lieberman, M. Redshaw, J. Caldwell, L. Notarianni, R. L. Smith & R. W. Beard: The influence of maternal analgesia on neonatal behavior: II. Epidural bupivacaine. Brit. J. Obstet. Gynecol. 1981, 88, 407-413.
20. Rutten, A. J., C. Nancarrow, L. E. Mather, A. H. Ilsley, W. B. Runciman & R. N. Upton: Hemodynamic and central nervous system effects of intravenous bolus doses of lidocaine, bupivacaine and ropivacaine in sheep. Anesth. Analg. 1989, 69, 291-299.
21. Ryan, D. W.: Accidental intravenous injection of bupivacaine: A complication of obstetrical epidural anaesthesia. Case report. Brit. J. Anaesth. 1973, 43, 907-908.
22. Scanlon, J. W., W. U. Brown, J. B. Weiss & M. H. Alper: Neurobehavioural responses of newborn infants after maternal epidural anesthesia. Anesthesiology 1974, 40, 121-128.
23. Scanlon, J. W., G. W. Ostheimer, A. O. Lurie, W. U. Brown, J. B. Weiss & M. H. Alper: Neurobehavioural responses and drug concentrations in newborns after maternal epidural anesthesia with bupivacaine. Anesthesiology 1976, 45, 400-405.
24. Scott, D. B., A. Lee, D. Fagan, G. M. R. Bowler, P. Bloomfield & R. Lundh: Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth. Analg. 1989, 69, 563-569.
25. Thompson, E. M., C. M. Wilson, J. Moore & E. MeClean: Plasma bupivacaine levels associated with extradural anaesthesia for Caesarean section. Anaesthesia 1985, 40, 427-432.
26. Thornburn, J. & D. D. Moir: Bupivacaine toxicity in association with extradural analgesia for Caesarean section. Brit. J. Anaesth. 1984, 56, 551-553.
27. Tucker, G. T.: The role of pharmacokinetics in local anesthetic toxicity: The 1993 ASRA lecture. Reg. Anesth. 1994, 19, 155-163.
28. Wiener, P. C., M. I. Hogg & M. Rosen: Neonatal respiration, feeding and neurobehavioural state. Effects of intrapartum bupivacaine, pethidine and pethidine reversed by naloxone. Anaesthesia 1979, 34, 996-1004.
29. Åkerman, B., I. B. Hellberg & C. Trossvik: Primary evaluation of the local anaesthetic properties of the amino amide agent ropivacaine (LEA103). Acta anaesthesiol. scand. 1988, 32, 571-578.