The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis: The solution structure of aurein 1.2

European Journal of Biochemistry

Volumn 267, Issue 17, 2000, Pages 5330-5341

  Rozek, Tomas ^a   Wegener, Kate L ^a   Bowie, John H ^a   Olver, Ian N ^a,b   Carver, John A ^c   Wallace, John C ^a   Tyler, Michael J ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Amphipathic helix; Antibacterial peptides; Anticancer activity; NMR solution structure; Sequencing

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; AUREIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; FROG; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; ANURA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SCREENING ASSAYS, ANTITUMOR; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION;

EID: 0033859322     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01536.x     Document Type: Article

References (72)

1. The toad, ugly and venomous, wears yet a precious jewel in his skin
2. Bioactive secretions of the amphibian integument
3. Peptides from frog skin
4. Amphibian skin: A promising resource for antimicrobial peptides
5. New antibiotic caerin 1 peptides from the skin secretions of the Australian tree frog Litoria chloris Comparison of the activities of the caerin 1 peptides from the genus Litoria
6. Host defence antibacterial peptides from skin secretions of Australian amphibians The relationship between structure and activity
7. Maculatin 1.1. An antimicrobial peptide from the Australian tree frog Litoria genimaculata; solution structure and biological activity
8. Host defence peptides from the skin glands of the Australian Blue Mountains tree-frog Litoria citropa
9. New antibiotic peptides from the dorsal glands of the Australian toadlet Uperoleia mjobergii
10. The solution structure and activity of caerin 1.1, an antimicrobiaI peptide from the Australian tree frog Litoria splendida
11. The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet Uperoleia mjobergii
12. 1H-NMR study of gramicidin A transmembrane ion channel: Head-to-head right-handed, single-stranded helices
13. A two-dimensional NMR study of the antimicrobial peptide magainin 2
14. Molecular recognition between membrane-spanning peptides
15. Mechanisms for the modulation of membrane bilayer properties by amphipathic helical peptides
16. Structure and function of channel forming peptides, magainins, cecropins, melittin and alamethicin
17. Magainins as paradigm for the mode of action of pore forming polypeptides
18. Structure and orientation of the antibiotic peptide magainin in membranes by solid-state NMR
19. A Field Guide to Australian Frogs
20. Description de quelques reptiles nouveaux ou peu connus
21. Ueber einige neue oder seltene Batrachier aus Australien und dem tropischen Amerika
22. A novel method for the release and collection of dermal glandular secretions from the skin of frogs
23. High-sensitivity sequencing with a gas-phase sequencer
24. Larger scale multipin peptide synthesis
25. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 3rd approved standard
26. 1H-NMR spectra of proteins via double quantum filtering
27. 1H NMR spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy
28. Investigation of exchange processes by two-dimensional NMR spectroscopy
29. 1H spin-spin coupling constants in proteins
30. Effective combination of gradients and crafted RF pulses for water suppression in biological samples
31. 1H spin system identification in macromolecules
32. Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity
33. 12 through the use of new two-dimensional NMR experiments
34. The program XEASY for computer supported NMR spectral analysis of biological macromolecules
35. Solution structure of the human pp. 60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide
36. Computational challenges for macromolecular structure determination by X-ray crystallography and solution NMR-spectroscopy
37. Sampling properties of simulated annealing
38. Floating stereospecific assignment revisited - Application to an 18 kDa protein and comparison with J-coupling data
39. Accurate bond and angle parameters for x-ray protein structure refinement
40. MOLMOL: A program for display and analysis of macromolecular structures
41. 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbour effects
42. The relationship between chemical shift and secondary structure
43. Relationship between NMR chemical shift and protein secondary structure
44. The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy
45. 13C chemical-shift data
46. 3-Dimensional structure in solution of the calcium channel blocker ω-conotoxin
47. Stereochemical quality of protein structure coordinates
48. 2
49. Synthesis and characterisation of bacterial oligopeptides designed on the basis of an insect anti-bacterial peptide
50. Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides
51. Biochemical techniques and problems in anuran evolution
52. Biosynthesis of defensins and other antimicrobial peptides
53. A novel endopeptidase from Xenopus that recognises α-helical structure
54. Alamethicin helices in a bilayer and in solution: A molecular dynamics simulation study
55. Structure and orientation of the antimicrobial peptide cecropin p1 within phospholipid membranes
56. 1H NMR study of granimicidin A transmembrane ion channels
57. Spectrum of antimicrobial activity and assembly of dermaseptin b and its precursor form in phospholipid membranes
58. Membrane thinning caused by magainin 2
59. Structure and orientation of the pore-forming peptide, melitten, in lipid bilayers
60. Anticancer efficacy of Magainin2 and analogue peptides
61. Biochemistry. Addison-Wesley Publishers Co
62. Differentiation dependent expression of phosphatidyl serine in mammalian plasma membranes: Quantitative assessment of outer-leaflet lipid by prothrombin complex formation
63. Elevated expression of phosphatidyl serine in the outer membrane leaflet of human tumor cells and recognition of activated human blood monocycles
64. Molecular basis for prokaryotic specificity of magainin-induced lysis
65. Aquatic sex pheromone from a male frog
66. Differences in skin peptides of the male and female Australian magnificent tree frog Litoria splendida - A three year monitoring survey: The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and the antibiotic caerin 1.10
67. Effect of trifluoroethanol on protein secondary structure: An NMR and CD study using a synthetic actin peptide
68. Folding of peptide fragments comprising the complete sequence of proteins; modes for initiation of protein folding. 1. Myohemerhthrin