Cancer research 2000: Drug resistance, new targets and drugs in development

Drug Resistance Updates

Volumn 3, Issue 3, 2000, Pages 133-138

  Broxterman, Henk J ^a,b   Georgopapadakou, Nafsika ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(4,5 DIMETHYL 1H PYRROL 2 YL)METHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ABC TRANSPORTER; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; APIGENIN; BCR ABL PROTEIN; BIRICODAR; BMS 203928; BMS 26524601; BMY 028647; CRYPTOPHYCIN 52; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); CYCLOSPORIN DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ELACRIDAR; ER 35744; FIBROBLAST GROWTH FACTOR; GW 8510; GYRASE INHIBITOR; KARENITECIN; MULTIDRUG RESISTANCE PROTEIN; OC 144093; PACLITAXEL; PROTEINASE INHIBITOR; RO 317453; SU 9516; TARIQUIDAR; TOPOTECAN; TRABECTEDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSPODAR; ZM 445526; ZOSUQUIDAR;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; BREAST CANCER; CANCER RESEARCH; CANCER RESISTANCE; CELL CYCLE; GENOME; HUMAN; HUMAN CELL; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033858635     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1054/drup.2000.0145     Document Type: Article

References (18)

1. Basic fibroblast growth factor sensitizes NIH 3T3 cells to apoptosis induced by cisplatin
2. Doxorubicin gradients in human breast cancer
3. pH and drug resistance in tumors
4. MDRI gene expression in primary and advanced breast cancer
5. Isolation and characterization of an IGROV-I human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)
6. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
7. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
8. Reversal of resistance by GFI20918 in cell lines expressing the ABC half-transporter, MXR
9. A beta-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance
10. High-resolution model of the microtubule
11. Apaf-I and caspase-9 in p53-dependent apoptosis and tumor inhibition
12. Can HER2 status predict response to cancer therapy?
13. Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
14. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
15. Steering anti-cancer drugs away from the TRAIL
16. Cell permeable Bcl-2 binding peptides: A chemical approach to apoptosis induction in tumor cells
17. A common pharmacophore for Taxol and the Epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain
18. Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo