An update on Clostridium perfringens enterotoxin

Journal of Natural Toxins

Volumn 9, Issue 3, 2000, Pages 251-266

  Sarker, M R ^a   Singh, U ^a   McClane, B A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENTEROTOXIN;

BACTERIAL INFECTION; BIOSYNTHESIS; CHEMISTRY; CLOSTRIDIUM PERFRINGENS; GASTROINTESTINAL DISEASE; GENE EXPRESSION REGULATION; HUMAN; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; REVIEW; STRUCTURE ACTIVITY RELATION; VIRULENCE;

CLOSTRIDIUM INFECTIONS; CLOSTRIDIUM PERFRINGENS; ENTEROTOXINS; GASTROINTESTINAL DISEASES; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRULENCE;

EID: 0033857725     PISSN: 10588108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (77)

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2. Clostridium perfringens type E animal enteritis isolates with highly conserved, silent enterotoxin sequences
3. Characterization of an outbreak of Clostridium perfringens food poisoning by quantitative fecal culture and fecal enterotoxin measurement
4. Newly described clostridial diseases of the gastrointestinal tract: Clostridium perfringens enterotoxin-associated diarrhea and neutropenic enterocolitis due to Clostridium septicum
5. Epidemiology of diarrhea caused by enterotoxigenic Clostridium perfringens
6. Enterotoxigenic Clostridium perfringens: A possible cause of antibiotic-associated diarrhea
7. Detection of Clostridium perfringens and its enterotoxin in cases of sporadic diarrhea
8. Evidence that Tn5565, which includes the enterotoxin gene in Clostridium perfringens, can have a circular form which may be a transposition intermediate
9. A complex array of Hpr consensus DNA recognition sequences proximal to the enterotoxin gene in Clostridium perfringens type A
10. The Clostridium perfringens enterotoxin gene is on a transposable element in type A human food poisoning strains
11. Genomic diversity and organization of virulence genes in the pathogenic anaerobe Clostridium perfringens
12. Clostridium perfringens in spontaneous and antibiotic-associated diarrhoea of man and other animals
13. Phenotypic characterization of enterotoxigenic Clostridium perfringens isolates from non-foodborne human gastrointestinal diseases
14. Evidence that the enterotoxin gene can be episomal in Clostridium perfringens isolates associated with nonfoodborne human gastrointestinal diseases
15. The enterotoxin gene (cpe) of Clostridium perfringens can be chromosomal or plasmid-borne
16. Regulated expression of Clostridium perfringens enterotoxin in naturally cpe-negative type A, B, and C isolates of C. perfringens
17. Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli
18. Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
19. Beta2 toxin, a novel toxin produced by Clostridium perfringens
20. Molecular variation between the alpha-toxins from the type strain (NCTC 8237) and clinical isolates of Clostridium perfringens associated with disease in man and animals
21. Chymotrypsin treatment increases the activity of Clostridium perfringens enterotoxin
22. Trypsin activation of enterotoxin from Clostridium perfringens type A
23. A recombinant C-terminal toxin fragment provides evidence that membrane insertion is important for Clostridium perfringens enterotoxin cytotoxity
24. Localization of the receptor-binding region of Clostridium perfringens enterotoxin utilizing cloned toxin fragments and synthetic peptides. The 30 C-terminal amino acids define a functional binding region
25. Mapping functional regions of Clostridium perfringens type A enterotoxin
26. Molecular cloning of the 3' half of the Clostridium perfringens enterotoxin gene and demonstration that this region encodes receptor-binding activity
27. Cationic currects inducted by Clostridium perfringens type A enterotoxin in human intestinal Caco-2 cells
28. The role of enterotoxin in Clostridium perfringens type A enteritis
29. Isolation and function of a Clostridium perfringens enterotoxin fragment
30. Evidence that alterations in small molecule permeability are involved in the Clostridium perfringens type-A enterotoxin-induced inhibition of macromolecular synthesis in Vero cells
31. Diagnostic importance of Clostridium perfringens enterotoxin analysis in recurring enteritis among the elderly, chronic care psychiatric patients
32. Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin
33. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo
34. Identification of a Clostridium perfringens enterotoxin region required for large complex formation and cytotoxicity by random mutagenesis
35. Evidence that region(s) of the Clostridium perfringens enterotoxin molecule remain exposed on the external surface of the mammalian plasma membrane when the toxin is sequestered in small or large complex
36. Deletion analysis of the Clostridium perfringens enterotoxin
37. Comparison of Western immunoblots and gene detection assays for identification of potentially enterotoxigenic isolates of Clostridium perfringens
38. Enterotoxin formation by Clostridium perfringens type A in a defined medium
39. Primary action of Clostridium perfringens type A enterotoxin in HeLa and Vero cells in the absence of extracellular calcium: Rapid and characteristic changes in membrane permeability
40. Calcium-independent and calcium-dependent steps in action of Clostridium perfringens enterotoxin
41. Osmotic stabilizers differentially inhibit permeability alterations induced in Vero cells by Clostridium perfringens enterotoxin
42. Clostridium perfringens enterotoxin acts by producing small molecule permeability alterations in plasma membranes
43. Clostridium perfringens
44. Enterotoxie clostridia: Clostridium perfringens type A and Clostridium difficile
45. Characterization of membrane permeability alterations induced in Vero cells by Clostridium perfringens enterotoxin
46. Protective effects of osmotic stabilizers on morphological and permeability alterations induced in Vero cells by Clostridium perfringens enterotoxin
47. Studies of Clostridium perfringens enterotoxin action at different temperatures demonstrate a correlation between complex formation and cytotoxicity
48. Divalent cation involvement in the action of Clostridium perfringens type A enterotoxin
49. 125 I-enterotoxin to rabbit intestinal cells
50. Toxins of Clostridium perfringens types A, B, C, D, and E
51. The effects of Clostridium perfringens enterotoxin on rat and rabbit ileum: An electron microscopy study
52. In vivo effects of enterotoxin from Clostridium perfringens type A in rabbit colon: Binding vs. biologic activity
53. Histopathological effect of Clostridium perfringens enterotoxin in the rabbit ileum
54. Regional localization of activity of Clostridium perfringens type A enterotoxin in the rabbit ileum, jejunum and duodenum
55. Binding vs. biological activity of Clostridium perfringens enterotoxin in Vero cells
56. Regulation of enterotoxin production in Clostridium perfringens
57. Expression from the Clostridium perfringens cpe promoter in C. perfringens and Bacillus subtilus
58. A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin-neutralizing antibody response in mice
59. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
60. Enterotoxigenic Clostridium perfringens as a cause of sporadic cases of diarrhoea
61. Clostridium perfringens enterotoxin impairs bile flow in the isolated perfused rat liver and induces fragmentation of tight junction fibrils
62. Inactivation of the gene (cpe) encoding Clostridium perfringens enterotoxin eliminates the ability of two cpe-positive C. perfringens type A human gastrointestinal disease isolates to affect rabbit ileal loops
63. Clostridium perfringens type A enterotoxin induces concurrent development of tissue damage and fluid accumulation in the rabbit ileum
64. Experimental diarrhea in human volunteers following oral administration of Clostridium perfringens enterotoxin
65. Clostridial enteric diseases of domestic animals
66. Genotyping of Clostridium perfringens by polymerase chain reaction is a useful adjunct to diagnosis of clostridial enteric disease in animals
67. Clostridium perfringens enterotoxin fragments removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier
68. Transition-state regulators: Sentinels of Bacillus subtilis post-exponential gene expression
69. Clostridium perfringens type A food poisoning. II. Response of the rabbit ileum as an indication of enteropathogenicity of strains of Clostridium perfringens
70. Identification and isolation of the binding substance for Clostridium perfringens enterotoxin on Vero cells
71. Enterotoxin of Clostridium perfringens type A forms ion-permeable channels in a lipid bilayer membrane
72. Synthetic DNA probes for detection of enterotoxigenic Clostridium perfringens strains isolated from outbreaks of food poisoning
73. Characterization of membrane-associated Clostridium perfringens enterotoxin following Pronase treatment
74. Evidence that an ~50 kDa mammalian plasma membrane protein with receptor-like properties mediates the amphiphilicity of specifically-bound Clostridium perfringens enterotoxin
75. Identification of a 50,000 M(±) protein from rabbit brush border membranes that binds Clostridium perfringens enterotoxin
76. Preliminary evidence that Clostridium perfringens type A enterotoxin is present in a 160,000-M(±) complex in mammalian membranes
77. Identification and characterization of sporulation-dependent promoters upstream of the enterotoxin gene (cpe) of Clostridium perfringens