Immunocytochemical detection of the homeobox B3, B4, and C6 gene products in childhood medulloblastomas/primitive neuroectodermal tumors

Anticancer Research

Volumn 20, Issue 3 A, 2000, Pages 1769-1780

  Bodey, Bela ^a,e   Bodey Jr , Bela ^a   Siegel, Stuart E ^b   Kaiser, Hans E ^c,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF VIENNA   (Austria)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Childhood intracranial malignancies; Homeobox genes and proteins; Immunocytochemistry; Medulloblastomas (MEDs); Oncofetal antigens; Polyclonal antibodies; Primitive neuroectodermal tumors (PNETs); Trancriptional regulation

Indexed keywords

ALKALINE PHOSPHATASE; CD34 ANTIGEN; DNA BINDING PROTEIN; FORMALDEHYDE; HOMEODOMAIN PROTEIN; ONCOFETAL ANTIGEN; PARAFFIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; BONE MARROW; BREAST CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CHILD; CONTROLLED STUDY; CULTURE MEDIUM; DEVELOPMENTAL GENETICS; DNA SEQUENCE; EARLY DIAGNOSIS; HEMATOPOIETIC STEM CELL; HOMEOBOX; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LYMPHOID TISSUE; MEDULLOBLASTOMA; MOLECULAR BIOLOGY; MYELOPROLIFERATIVE DISORDER; NEUROECTODERM TUMOR; PHENOTYPE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ADOLESCENT; BIOLOGICAL MARKERS; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; GENES, NEOPLASM; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MEDULLOBLASTOMA; NEUROECTODERMAL TUMORS, PRIMITIVE;

EID: 0033856515     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (78)

1. Bürglin TR: Homeodomain Proteins. In: Encyclopedia of Molecular Biology and Molecular Medicine (Meyers RA, ed). Vol 3. Weinheim, VCH Verlagsgesellschaft mbH, p1996, pp 55-76.
2. Kun LE: Brain tumors: challenges and directions. Pediatr Clin North Am 44: 907-917, 1997.
3. Kedar A: Chemotherapy for pediatric brain tumors. Semin Pediatr Neurol 4: 320-332, 1997.
4. Becker LE, Hinton D: Primitive neuroectodermal tumors of the central nervous system. Human Pathol 14: 538-550, 1983.
5. Becker LE, Hinton D: Primitive neuroepithelial tumors of the central nervous system. In: Pathology of Neoplasia in Children and Adolescents (Feingold M, ed). Philadelphia, WB Saunders, 1986, pp 397-418.
6. van den Berg SR, Herman MM, Rubinstein LJ: Embryonal central neuroepithelial tumors: current concepts and future challenges. Cancer Metast Rev 5: 343-364, 1987.
7. Triche TJ: Primitive neuroectodermal tumors. Arch Pathol Lab Med 111: 311-312, 1987.
8. Packer RJ: Childhood tumors. Curr Opin Pediatr 9: 551-557, 1997.
9. Rickert CH, Probst-Cousin S, Gullotta F: Primary intracranial neoplasms of infancy and early childhood. Childs Nerv Syst 13: 507-513, 1997.
10. Pomeroy SL, Sutton ME, Goumnerova LC, Segal RA: Neurotrophins in cerebellar granule cell development and medulloblastoma. J Neurooncol 35: 347-352, 1997.
11. Nishio S, Morioka T, Takeshita I, Fukui M: Medulloblastoma: survival and late recurrence after the Collins' risk period. Neurosurg Rev 20: 245-249, 1997.
12. Reardon DA, Michalkiewicz E, Boyett JM, Sublett JE. Entrekin RE, Ragsdale ST, Valentine MB, Behm FG, Li H, Heideman RL, Kun LE, Shapiro DN, Look AT: Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res 57: 4042-4047, 1997.
13. Stornaiuolo A, Acampora D, Pannese M, D'Esposito M, Morelli F, Migliaccio E, Rambaldi M, Faiella A, Nigro V, Simeone A, Boncinelli E: Human HOX genes are differentially activated by retinoic acid in embryonal carcinoma cells according to their position within the four loci. Cell Differ Dev 31: 119-127, 1990.
14. Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Care A, Faiella A, Stornaiuolo A, Russo G, Simeone A. Boncinelli E, Peschle C: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. Differentiation 40: 191-197, 1989.
15. Mavilio F, Simeone A, Boncinelli E, Andrews PW: Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid. Differentiation 37: 73-79, 1988.
16. Simeone A, Acampora D, D'Esposito M, Faiella A, Pannese M, Scotto L, Montanucci M, D'Alessandro G, Mavilio F, Boncinelli E: Posttranscriptional control of human homeobox gene expression in induced NTERA-2 embryonal carcinoma cells. Mol Reprod Dev 1: 107-115, 1989.
17. Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A, Della Valle G, Boncinelli E: Expression of HOX homeogenes in human neuroblastoma cell culture lines. Differentiation 45: 61-69, 1990.
18. Maconochie MK, Nonchev S, Studer M, Chan SK, Popperl H, Sham MH, Mann RS, Krumlauf R: Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxbl. Genes Dev 11: 1885-1895, 1997.
19. Gould A, Morrison A, Sproat G, White RA, Krumlauf R: Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns.Genes Dev 11: 900-913, 1997.
20. Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK: Overexpression of HOX-B4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9: 1753-1765, 1995.
21. Rancourt DE, Tsuzuki T, Capecchi MR: Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev 9: 108-122, 1995.
22. Sun J, Rose JB, Bird P: Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. J Biol Chem 270: 16089-16096, 1995.
23. Hogan BL, Holland PW, Lumsden A: Expression of the homeobox gene, Hox 2.1, during mouse embryogenesis. Cell Diff Dev 25: 39-44, 1988.
24. Safaei R: A target of the HoxB5 gene from the mouse nervous system. Brain Res Dev Brain Res 100: 5-12, 1997.
25. Janckila AJ, Yam LT, Li C-Y: Immunoalkaline phosphatase cytochemistry. Amer J Clin Pathol 84: 476-480, 1985.
26. Bodey B, Zeltzer PM, Saldivar V, Kemshead J: Immunophenotyping of childhood astrocytomas with a library of monoclonal antibodies. Int J Cancer 45: 1079-1087, 1990.
27. Yam LT, Janckila AJ, Epremian BE, Li C-Y: Diagnostic significance of levamisole-resistant alkaline phosphatase in cytochemistry and immunocytochemistry. Amer J Clin Pathol 91: 31-36, 1989.
28. Strasburger CJ, Amir-Zaltsman Y, Kohen F: The avidin-biotin reaction as an universal amplification system in immunoassays. Prog Clin Biol Res 285: 79-100, 1988.
29. Wilchek M, Bayer EA: Introduction to avidin-hiotin technology. Methods Enzymol 184: 5-13, 1990.
30. Duhamel RC, Whitehead JS: Prevention of nonspecific binding of avidin. Methods Enzymol 184: 201-207, 1990.
31. Diamandis EP, Christopoulos TK: The biotin-(strept)avidin system: principles and applications in biotechnology. Clin Chem 37: 625-636, 1991.
32. Lawrence HJ, Sauvageau G, Humphries RK, Largman C: The role of HOX homeobox genes in normal and leukemic hematopoiesis. Stem Cells 14: 281-291, 1996.
33. Thorsteinsdottir U, Sauvageau G, Humphries RK: Hox homeobox genes as regulators of normal and leukemic hematopoiesis. Hematol Oncol Clin North Am 11: 1221-1237, 1997.
34. Shimamoto T, Ohyashiki K, Toyama K, Takeshita K: Homeobox genes in hematopoiesis and leukemogenesis. Int J Hematol 67: 339-350, 1998.
35. Chiha S: Homeobox genes in normal hematopoiesis and leukemogenesis. Int J Hematol 68: 343-353, 1998.
36. Moskow JJ, Bullrich F, Huehner K, Daar IO, Buchberg AM: Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol Cell Biol 15: 5434-5443, 1995.
37. Nakamura T, Largaespada DA, Shaughnessy JD Jr, Jenkins NA, Copeland NG: Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet 12: 149-153, 1996.
38. Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C: Stage- and lineage-specific expression of the HOX-A10 homeohox gene in normal and leukemic hematopoietic cells. Exp Hematol 23: 1160-1166, 1995.
39. Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE: Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. Leukemia 13: 687-698, 1999.
40. Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau CJ: Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.EMBO J 17: 3714-3725, 1998.
41. Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK: Overexpression of HOX-A10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol 17: 495-505, 1997.
42. Ohnishi K, Tobita T, Sinjo K, Takeshita A, Ohno R: Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation. Leuk Lymphoma 11: 599-608, 1998.
43. Cillo C, Cantile M, Mortarini R, Barba P, Parmiani G, Anichini A: Differential patterns of HOX gene expression are associated with specific integrin and ICAM profiles in clonal populations isolated from a single human melanoma metastasis, Int J Cancer 66: 642-697, 1996.
44. Lawrence HJ, Stage KM, Mathews CH, Detmer K, Scihienski R, MacKenzie M, Migliaccio E, Boncinelli E, Largman C: Expression of HOX C homeobox genes in lymphoid cells. Cell Growth Differ 4: 665-669, 1993.
45. Bijl JJ, van Oostveen JW, Walboomers JM, Brink AT, Vos W, Ossenkoppele GJ. Meijer CJ: Differentiation and cell-type-restricted expression of HOXC4, HOXC5 and HOXC6 in myeloid leukcmias and normal myeloid cells. Leukemia 12: 1724-1732, 1998.
46. Meazza R, Faiella A, Corsetti MT, Airoldi I, Ferrini S, Boncinelli E, Corte G: Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes. Blood 85: 2084-90, 1995.
47. Bijl J, van Oostveen JW, Kreike M, Rieger E, van der Raaij-Helmer LM, Walboomers JM, Corte G, Boncinelli E, van den Brule AJ, Meijer CJ: Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue. Blood 87: 1737-1745, 1996.
48. Bijl JJ, van Oostveen JW, Walboomers JM. Horstman A, van den Brule AJ, Willemze R, Meijer CJ: HOXC4, HOXC5, and HOXC6 expression in non-Hodgkin's lymphoma: preferential expression of the HOXC5 gene in primary cutaneous anaplastic T-cell and orogastrointestinal tract mucosa-associated B-cell lymphomas. Blood 90: 4116-4125, 1997.
49. Bijl JJ, Rieger E, van Oostveen JW, Walboomers JM, Kreike M, Willemze R, Meijer CJ: HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas. Am J Pathol 151: 1067-1074, 1997.
50. Alami Y, Castronovo V, Belotli D, Flagiello D, Clausse N: HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes. Biochem Biophys Res Commun 257: 738-745, 1999.
51. Shim C, Zhang W, Rhee CH, Lee JH: Profiling of differentially expressed genes in human primary cervical cancer by complementary DNA expression array. Clin Cancer Res 4: 3045-3050, 1998.
52. Osborne J, Hu C, Hawley C, Underwood LJ, O'Brien TJ, Baker VV: Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma. J Soc Gynecol Investig 5: 277-280, 1998.
53. Boylan JF, Lohnes D, Taneja R, Chambon P, Gudas LJ: Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment. Proc Natl Acad Sci USA 90: 9601-9605, 1993.
54. Pratt MA, Langston AW, Gudas LJ, McBurney MW: Retinoic acid fails to induce expression of Hox genes in differentiation-defective murine embryonal carcinoma cells carrying a mutant gene for alpha retinoic acid receptor. Differentiation 53: 105-113, 1993.
55. Langston AW, Gudas LJ: Retinoic acid and homeobox gene regulation. Curr Opin Genet Dev 4: 550-555, 1994.
56. Knoepfler PS, Kamps MP: The Pbx family of proteins is strongly upregulated by a post-transcriptional mechanism during retinoic acid-induced differentiation of P19 embryonal carcinoma cells. Mech Dev 63: 5-14, 1997.
57. Simeone A, Acampora D, Arcioni L, Andrews PW, Boncinelli E, Mavilio F: Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature 346: 763-766, 1990.
58. Chang CP, de Vivo I, deary ML: The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis. Mol Cell Biol 17: 81-88, 1997.
59. Krosl J, Baban S, Krosl G, Rozenfeld S, Largman C, Sauvageau G: Cellular proliferation and transformation induced by HOX-B4 and HOXB3 proteins involves cooperation with PBX1. Oncogene 16: 3403-3412, 1998.
60. Tiberio C, Barba P, Magli MC, Arvelo F, Le Chevalier T, Poupon MF, Cillo C: HOX gene expression in human small-cell lung cancers xenografted into nude mice. Int J Cancer 58: 608-615, 1994.
61. Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B: Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. FEBS Lett 415: 263-267, 1997.
62. Flagiello D, Poupon MF, Cillo C, Dutrillaux B, Malfoy B: Relationship between DNA methylation and gene expression of the HOXB gene cluster in small cell lung cancers. FEBS Lett 380: 103-107, 1996.
63. Chariot A, Moreau L, Senterre G, Sobel ME, Castronovo V: Retinoic acid induces three newly cloned HOXA1 transcripts in MCF7 breast cancer cells. Biochem Biophys Res Commun 215: 713-720, 1995.
64. Chariot A, Castronovo V: Detection of HOXAI expression in human breast cancer. Biochem Biophys Res Commun 222: 292-297, 1996.
65. Suzuki M, Tanaka M, Iwase T, Naito Y, Sugimura H, Kino I: Over-expression of HOX-8, the human homologue of the mouse Hox-8 homeobox gene, in human tumors. Biochem Biophys Res Commun 194: 187-193, 1993.
66. De Vita G, Barba P, Odartchenko N, Givel JC, Freschi G, Bucciarelli Ci, Magli MC, Boncinelli E, Cillo C: Expression of homeobox-containing genes in primary and metastatic colorectal cancer. Eur J Cancer 29A: 887-893, 1993.
67. Manohar CF, Furtado MR, Salwen HR, Conn SL: Hox gene expression in differentiating human neuroblastoma cells. Biochem Mol Biol Int 30: 733-741, 1993.
68. Manohar CF, Salwen HR, Furtado MR, Cohn SL: Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. Tumour Biol 17: 34-47, 1996.
69. Cillo C, Barba P, Freschi G, Bucciarelli G, Magli MC, Boncinelli E: HOX gene expression in normal and neoplastic human kidney. Int J Cancer 51: 892-897, 1992.
70. Deschamps J, Meijlink F: Mammalian homeobox genes in normal development and neoplasia. Crit Rev Oncog 3: 117-173, 1992.
71. Friedmann Y, Daniel CA, Strickland P, Daniel CW: Hox genes in normal and neoplastic mouse mammary gland. Cancer Res 54: 5981-5985, 1994.
72. Redline RW, Hudock P, MacFee M, Patterson P: Expression of AhdB-type homeobox genes in human tumors. Lab Invest 71: 663-670, 1994.
73. Cillo C: HOX genes in human cancers. Invasion Metastasis 14: 38-49, 1994-95.
74. Stuart ET, Yokota Y, Gruss P: PAX and HOX in neoplasia. Adv Genet 33: 255-274, 1995.
75. Mark M, Rijli FM, Chambon P: Homeobox genes in embryogenesis and pathogenesis. Pediatr Res 42: 421-429, 1997.
76. Boudreau N, Andrews C, Srebrow A, Ravanpay A, Cheresh DA: Induction of the angiogenic phenotype by Hox D3. J Cell Biol 139: 257-264, 1997.
77. Care A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C, Colombo MP: HOXB7 constitutively activates basic fibroblast growth factor in melanomas. Mol Cell Biol 16: 4842-4851, 1996.
78. Kloen P, Visker MH, Olijve W, van Zoelen EJ, Boersma CJ: Cell-type-specific modulation of Hox gene expression by members of the TGF-beta superfamily: a comparison between human osteosarcoma and neuroblastoma cell lines. Biochem Biophys Res Commun 233: 365-369, 1997.