Chronic toxicity of nonylphenol and ethinylestradiol: Haematological and histopathological effects in juvenile Common carp (Cyprinus carpio)

Aquatic Toxicology

Volumn 51, Issue 1, 2000, Pages 69-78

  Schwaiger, J ^a   Spieser, O H ^b   Bauer, C ^a   Ferling, H ^a   Mallow, U ^a   Kalbfus, W ^c   Negele, R D ^a  

^a Inst Water Res D   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c Institute for Water Research   (Germany)

Author keywords

Ethinylestradiol; Fish; Nonylphenol; Toxicity

Indexed keywords

ETHINYLESTRADIOL; NONYLPHENOL;

ANEMIA; ANIMAL EXPERIMENT; ARTICLE; CARP; CHRONIC TOXICITY; CONTROLLED STUDY; ECOTOXICOLOGY; ENVIRONMENTAL EXPOSURE; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BLOOD CELL COUNT; CARPS; ENDPOINT DETERMINATION; ERYTHROCYTE COUNT; ESTRADIOL CONGENERS; ETHINYL ESTRADIOL; HEMOGLOBINS; KIDNEY; LIVER; PHENOLS; SPLEEN;

CYPRINUS CARPIO;

EID: 0033856403     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-445X(00)00098-9     Document Type: Article

References (38)

1. Ahel M., Giger W. Partitioning of alkylphenols and alkylphenol polyethoxylates between water and organic solvents. Chemosphere. 26:1993;1471-1478.
2. Ahel M., Giger W., Schaffner C. Behaviour of alkylphenol polyethoxylate surfactants in the aquatic environment-II. Occurrence and transformation in rivers. Wat. Res. 28:(5):1994;1143-1152.
3. Arcand-Hoy L., Benson W.H. Fish reproduction: an ecologically relevant indicator of endocrine disruption. Environ. Toxicol. Chem. 17:(1):1998;49-57.
4. Ashfield L.A., Pottinger T.G., Sumpter J.P. Exposure of female juvenile rainbow trout to alkylphenolic compounds results in modifications to growth and ovosomatic index. Environ. Toxicol. Chem. 17:(3):1998;679-686.
5. Benson W.H., Nimrod A.C. Reproduction and development of Japanese medaka following an early life stage exposure to xenoestrogens. Aquat. Toxicol. 44:(1-2):1998;141-156.
6. Blackburn M.A., Waldock M.J. Concentrations of alkylphenols in rivers and estuaries in England and Wales. Wat. Res. 29:(7):1995;1623-1629.
7. Bolis L., D'Angelo P., Delfino G. Action of some anionic and non-ionic detergents on human erythrocyte membranes. Boll. Soc. Ital. Biol. Sper. 53:(20):1977;1755-1761.
8. Capel-Edwards K., Hall D.E., Sansom A.G. Hematological changes observed in female beagle dogs given ethynylestradiol. Toxicol. Appl. Pharmacol. 20:1971;319-326.
9. Cho B.H.S., Smith T.L., Park J.R., Kummerow F.A. Effects of estrogen-induced hyperlipidemia on the erythrocyte membrane in chicks. Lipids. 23:(9):1988;853-856.
10. Christiansen T., Korsgaard B., Jespersen Å. Effects of nonylphenol and 17β-oestradiol on vitellogenin synthesis, testicular structure and cytology in male eelpout Zoarces viviparus. J. Exp. Biol. 201:1998;179-192.
11. Cooper R.L., Kavlock R.J. Endocrine disruptors and reproductive development: a weight-of-evidence overview. J. Endocrinol. 152:(2):1997;159-166.
12. Galembeck E., Alonso A., Meirelles N.C. Effects of polyethylene chain lenght on erythrocyte hemolysis induced by poly [oxyethylene (n) nonylphenol] nonionic surfactants. Chem. Biol. Interact. 113:(2):1998;91-103.
13. Gimeno S., Gerritsen A., Bowmer T., Komen H. Feminization of male carp. Nature. 384:1996;221-222.
14. Gimeno S., Komen H., Gerritsen A., Bowmer T. Feminization of young males of the common carp, Cyprinus carpio, exposed to 4-tert-pentylphenol during sexual differentiation. Aquat. Toxicol. 43:(2-3):1998;77-92.
15. Gray M.A., Metcalfe C.D. Induction of testis-ova in Japanese medaka (Oryzias latipes) exposed to p-nonylphenol. Environ. Toxicol. Chem. 16:(5):1997;1082-1086.
16. Hart J.E. Endocrine pathology of estrogens: species differences. Pharmacol. Ther. 47:(2):1990;203-218.
17. Haux C., Norberg B. The influence of estradiol-17β on the liver content of protein, lipids, glycogen and nucleic acids in juvenile rainbow trout, Salmo gairdneri. Comp. Biochem. Physiol. B. 81:1985;275-279.
18. Herman R.L., Kincaid H.L. Pathological effects of orally administered estradiol to rainbow trout. Aquaculture. 72:1988;165-172.
19. Holcombe G.W., Phipps G.L., Knuth M.L., Felhaber T. The acute toxicity of selected substituted phenols benzenes and benzoic acid esters to fathead minnows, Pimephales promelas. Environ. Pollut. Ser. A. 35:1984;367-381.
20. Istamanova, T.S., 1967. Disorders in hemoglobin synthesis during some forms of anemia. Vopr. Biofiz. Biokhim. Patol. Eritrotsitov, 9-13.
21. Jobling S., Sumpter J.P. Detergent components in sewage effluent are weakly oestrogenic to fish: an in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat. Toxicol. 27:1993;361-372.
22. Jobling S., Sheahan D., Osborne J.A., Matthiessen P., Sumpter J.P. Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ. Toxicol. Chem. 15:(2):1996;194-202.
23. Kime D.E. A strategy for assessing the effects of xenobiotics on fish reproduction. Sci. Total Environ. 225:(1-2):1999;3-11.
24. Landshman N., Bleiberg I. Effect of estradiol on erythropoiesis and megakaryocytopoiesis in mice. Isr. J. Med. Sci. 15:(2):1979;140-146.
25. Le Petit-Thevenin J., Rahmani-Jourdheuil D., Nobili O., Boyer J. Ethynylestradiol alters lipid composition and phosphatidylethanolamine metabolism in red blood cells. J. Steroid Biochem. 25:(4):1986;601-603.
26. 2+)-ATPase by nonylphenol. Biochemistry. 29:1990;3091-3101.
27. Miles-Richardson S.R., Pierens S.L., Nichols K.M., Kramer V.J., Snyder E.M., Snyder S.A., Render J.A., Fitzgerald S.D., Giesy J.P. Effects of waterborne exposure to 4-nonylphenol and nonylphenol ethoxylate on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas). Environ. Res. 80:(2):1999;S122-S137.
28. Naylor C.G., Mieure J.P., Adams W.J., Weeks J.A., Castaldi F.J., Ogle L.D., Romano R.R. Alkylphenol ethoxylates in the environment. J. Am. Oil Chem. Soc. 69:1992;695-703.
29. OECD, 1984. OECD guideline for testing of chemicals; No. 204, fish, 'prolonged toxicity study of at least 14 days'.
30. Purdom C.E., Hardiman P.A., Bye V.J., Eno N.C., Tyler C.R., Sumpter J.P. Estrogenic effects of effluents from sewage treatment works. Chem. Ecol. 8:1994;275-285.
31. Romeis, B., 1989. Mikroskopische Technik. Urban & Schwarzenberg, München, Wien, pp. 390-391.
32. Soto A.M., Justicia H., Wray J.W., Sonnenschein C. p-Nonylphenol: an estrogenic xenobiotic released from 'modified' polystyrene. Environ. Health Perspect. 92:1991;167-172.
33. Spieser O.H., Schwaiger J., Ferling H., Negele R.-D. An introduction to behavioral monitoring-effects of nonylphenol and ethinyl-estradiol on swimming behavior of juvenile carp. Butterworth F.M., Gunatilaka G., Gonsebatt M.E. Biomonitors and Biomarkers as Indicators of Environmental Change. 2000;Plenum Publishing Corp, New York.
34. Valtonen T. Seasonal and sex-bound variations in the carbohydrate metabolism of the liver of the white fish. Comp. Biochem. Physiol. A. 47:1974;713-727.
35. Vecchi A., Tagliabue A., Mantovani A., Anaclerio A., Barale C., Spreafico F. Steroid contraceptive agents and immunological reactivity in experimental animals. Biomedicine. 24:(4):1976;231-237.
36. Verstegen J., DeCoster R., Brasseur M. Effects of estrogens on blood parameters in the dog. Ann. Med. Vet. 125:(5):1981;397-403.
37. Washburn B.S., Krantz J.S., Avery E.H., Freedland R.A. Effects of estrogen on gluconeogenesis and related parameters in male rainbow trout. Am. J. Physiol. 264 (4 Part 2):1993;R720-725.
38. Yoshimura K. Biodegradation and fish toxicity of nonionic surfactants. JAOCS. 63:1986;1590.