Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells

Gastroenterology

Volumn 119, Issue 2, 2000, Pages 420-430

  Wingler, Kirstin ^a,b   Müller, Cordula ^a,b   Schmehl, Katrin ^a   Florian, Simone ^a   Brigelius Flohé, Regina ^a,b  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b UNIVERSITY OF POTSDAM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE PEROXIDASE; HYDROPEROXIDE; SELENIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; ENZYME SUBSTRATE; GASTROINTESTINAL TRACT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; INTESTINE ABSORPTION; LIPID ANALYSIS; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033855614     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2000.9521     Document Type: Article

References (58)

1. Role of oxygen-derived free radicals in digestive tract diseases
2. Lipid peroxides and nutrition
3. Routes of formation and toxic consequences of lipid oxidation products in foods
4. Determinants of intestinal detoxication of lipid hydroperoxides
5. Beyond cholesterol: Modifications of low-density lipoprotein that increases its atherogenicity
6. The role of lipid peroxidation and antioxidants in oxidative modification of LDL
7. Free radical biology: Xenobiotics, cancer and aging
8. Dietary carcinogens and anticarcinogens
9. The importance of free radicals and catalytic metal ions in human diseases
10. The levels of superoxide dismutase and catalase in human tissue as determined immunochemically
11. Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues
12. Distribution of glutathione and its related enzymes in small intestinal mucosa of rats
13. The expression of an intestinal form of glutathione peroxidase (GSHPx-GI) in rat intestinal epithelium
14. Cellular glutathione peroxidase knockout mice express normal levels of selenium-dependent plasma and phospholipid hydroperoxide glutathione peroxidases in various tissues
15. Developmental expression of extracellular glutathione peroxidase suggests antioxidant roles in deciduum, visceral yolk sac, and skin
16. Expression, characterisation, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI
17. Absorption and lymphatic transport of peroxidized lipids by rat small intestine in vivo: Role of mucosal GSH
18. Effect of dietary selenium and autoxidized lipids on the glutathione peroxidase system of gastrointestinal tract and other tissues in the rat
19. mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins
20. Gastrointestinal glutathione peroxidase
21. Absorption and metabolism of methyl linoleate hydroperoxides in rats
22. Oxidized lipids in the diet are a source of oxidized lipid in chylomicrons of human serum
23. Postprandial plasma lipid hydroperoxides: A possible link between diet and atherosclerosis
24. Toxicity of airoxidized soybean oil
25. 14C-methyl linoleate hydroperoxide
26. Intestinal absorption and lymphatic transport of methyl linoleate hydroperoxides and hydroxyoctadieneoate in the rat
27. Uptake of secondary autoxidation products of linoleic acid by the rat
28. Absorption and metabolism of autoxidation products of methyl linoleate in rat liver
29. Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body
30. Antioxidant enzymes in rat gastrointestinal tract
31. Utilization of selenium from different chemical entities for selenoprotein biosynthesis by mammalian cell lines
32. Effect of eicosapentaenoic acid on triacylglycerol transport in CaCo-2 cells
33. Characterization of the human colon carcinoma cell line (CaCo-2) as a model system for intestinal epithelial permeability
34. Preparation and purification of lipid hydroperoxides from arachidonic and γ-linolenic acids
35. Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellmann's reagent
36. A colorimetric micro-method for the determination of glutathione
37. Assays of glutathione peroxidase
38. A simple method for the isolation and purification of total lipids from animal tissues
39. Separation of lipid classes by high-performance liquid chromatography with the 'mass detector'
40. Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins
41. High performance chromatography of oxygenated fatty acids including enantiomer separation
42. Effects of chemical form and dosage on the incorporation of selenium into tissue proteins in rats
43. Synthesis of mono-and bifunctional peptide-dextran conjugates for the immobilization of peptide antigens on ELISA plates: Properties and application
44. Expression and chromosomal mapping of mouse Gpx2 gene encoding the gastrointestinal form of glutathione peroxidase, GPX-GI
45. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line CaCo-2 in culture
46. ω3-Lipid peroxides injure CaCo-2 cells: Relationship to the development of reduced glutathione antioxidant systems
47. Uptake of 13-hydroperoxylinoleic acid by cultured cells
48. Antioxidant defense in rat intestine and mesenteric lymph
49. Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats
50. The effect of oxidized lipids in the diet on serum lipoprotein peroxides in control and diabetic rats
51. Evaluation of isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma
52. Accelerating effect of 12-keto oleic acid on lipid peroxide and fluorescent productions in mouse liver homogenate
53. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides
54. Expression of gastrointestinal selenoproteins: Targets for selenium supplementation
55. Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice
56. Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
57. Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress
58. Phospholipid hydroperoxide glutathione peroxidase activity in various mouse organs during selenium deficiency and repletion