Long-term (>1 year) analyses of chimerism and tolerance in mixed allogeneic chimeric mice using normal mouse combinations

Stem Cells

Volumn 18, Issue 4, 2000, Pages 273-280

  Hayashi, Haruki ^a   Toki, Junko ^a   Zhexiong, Lian ^a   Sugiura, Kikuya ^a   Inoue, Kyoichi ^a   Ikehara, Susumu ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Mice; Mixed allogeneic chimeras; Pancreas allografts; Tolerance

Indexed keywords

ALLOGENIC BONE MARROW TRANSPLANTATION; ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CHIMERA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; FETUS; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PANCREAS TRANSPLANTATION; SPLEEN CELL;

ANIMALIA;

EID: 0033855017     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.18-4-273     Document Type: Article

References (22)

1. Nakamura T, Good RA, Yasumizu R et al. Successful liver allografts in mice by combination with allogeneic bone marrow transplantation. Proc Natl Acad Sci USA 1986;83:4529-4532.
2. Yasumizu R, Sugiura K, Iwai H etal. Treatment of type 1 diabetes mellitus in non-obese diabetic mice by transplantation of allogeneic bone marrow and pancreatic tissue. Proc Natl Acad Sci USA 1987;84:6555-6557.
3. Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 1984;307:168-170.
4. Starzl TE, Demetris AJ, Trucco M et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology 1993;17:1127-1152.
5. Hayashi H, Toki J, Lian Z et al. Analyses of extrathymic T cell differentiation in nu/nu mice by grafting embryonal organs. Immunobiology 1997;197:1-15.
6. Ogata H, Bradley WG, Inaba M et al. Long-term repopulation of hematolymphoid cells with only a few hematopoietic stem cells in mice. Proc Natl Acad Sci USA 1995;92:5945-5949.
7. Li H, Colson YL, Ildstad ST. Mixed allogeneic chimerism achieved by lethal and nonlethal conditioning approaches induces donor-specific tolerance to simultaneous islet allografts. Transplantation 1995;60:523-529.
8. Li H, Kaufman CL, Boggs SS et al. Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice. J Immunol 1996;156:380-388.
9. Ildstad ST, Wren SM, Oh E et al. Mixed allogeneic reconstitution (A + B→A) to induce donor-specific transplantation tolerance. Permanent acceptance of a simultaneous donor skin graft. Transplantation 1991;51:1262-1267.
10. Ildstad ST, Wren SM, Bluestone JA et al. Effect of selective T cell depletion of host and/or donor bone marrow on lymphopoietic repopulation, tolerance, and graft-vs-host disease in mixed allogeneic chimeras (B10 + B10.D2→B10). J Immunol 1986;136:28-33.
11. Hashimoto F, Sugiura K, Inoue K et al. Major histocompatibility complex restriction between hematopoietic stem cells and stromal cells in vivo. Blood 1997;89:49-54.
12. Taniguchi H, Abe M, Shirai T et al. Reconstitution ratio is critical for alloreactive T cell deletion and skin graft survival in mixed bone marrow chimeras. J Immunol 1995;155:5631-5636.
13. Yu JC, Webster M, Fox IJ. Clonal deletion: a mechanism of tolerance in mixed bone marrow chimeras. J Sur Res 1990;48:517-522.
14. Khan A, Tomita Y, Sykes M. Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance. Transplantation 1996;62:380-387.
15. Morita H, Sugiura K, Inaba M et al. A strategy for organ allografts without using immunosuppressants or irradiation. Proc Natl Acad Sci USA 1998;95:6947-6952.
16. Sykes M, Eisenthal A, Sachs DH. Mechanism of protection from graft-vs-host disease in murine mixed allogeneic chimeras. 1. Development of a null cell population suppressive of cell-mediated lympholysis responses and derived from the syngeneic bone marrow component. J Immunol 1988;140:2903-2911.
17. Sykes M, Sachs DH. Mechanisms of suppression in mixed allogeneic chimeras. Transplantation 1988;46(suppl 2):135-142.
18. Sugiura K, Kato K, Hashimoto F et al. Induction of donor-specific T cell anergy by portal venous injection of allogeneic cells. Immunobiol 1997;197:460-477.
19. Zavazava N, Kronke M. Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nat Med 1996;2:1005-1010.
20. Sugiura K, Inaba M, Ogata H et al. Wheat germ agglutinin-positive cells in a stem cell-enriched fraction of mouse bone marrow have potent natural suppressor activity. Proc Natl Acad Sci USA 1988;85:4824-4826.