Propofol selectively attenuates endothelium-dependent pulmonary vasodilation in chronically instrumented dogs

Anesthesiology

Volumn 93, Issue 2, 2000, Pages 437-446

  Kondo, U ^a   Kim, S O ^a   Murray, P A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Endothelium derived relaxing factors; Lung; Pulmonary circulation; Vasomotor tone

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; BRADYKININ; NITRIC OXIDE; PROLINE; PROPOFOL;

ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG SCREENING; INTRAVENOUS ANESTHESIA; LUNG BLOOD VESSEL; MALE; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0033854838     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200008000-00023     Document Type: Article

References (28)

1. Propofol: A new intravenous anesthetic
2. Propofol anesthesia results in profound pulmonary vasoconstriction in chronically-instrumented dogs following left lung autotransplantation (abstract)
3. - exchange (abstract)
4. +(ATP) channels
5. Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor
6. N(W)-nitro-L-arginine and the pulmonary vascular pressure-flow relationship in conscious dogs
7. Pulmonary vasoregulation by arginine vasopressin in conscious, halothane-anesthetized, and pentobarbital-anesthetized dogs with increased vasomotor tone
8. The effect of propofol on normal and increased pulmonary vascular resistance in isolated perfused rabbit lung
9. Endothelium-dependent pulmonary vasodilation in conscious dogs is selectively attenuated during isoflurane anesthesia
10. Pulmonary vasodilator response to adenosine triphosphate-sensitive potassium channel activation is attenuated during desflurane but preserved during sevoflurane anesthesia compared with the conscious state
11. Modification of endothelium-dependent relaxation by propofol, ketamine, and midazolam
12. Effects of propofol on isolated rabbit mesenteric arteries and veins
13. Propofol stimulates nitric oxide release from cultured porcine aortic endothelial cells
14. Propofol-associated dilation of rat distal coronary arteries is mediated by multiple substances, including endothelium-derived nitric oxide
15. Haemodynamic changes during anaesthesia induced and maintained with propofol
16. Peripheral vascular effects of thiopental and propofol in humans with artificial hearts
17. Direct effects of intravenous anesthetics on pulmonary vascular resistance in the isolated rat lung
18. The pulmonary vascular response to propofol in the isolated perfused rat lung
19. Responses to propofol in the pulmonary vascular bed of the rat
20. Effects of propofol and thiopental in isolated rat aorta and pulmonary artery
21. Effects of propofol on pulmonary and systemic arterial pressure-flow relationships in hyperoxic and hypoxic dogs
22. Differential effects of general anesthesia on cGMP-mediated pulmonary vasodilation
23. Halothane and enflurane attenuate pulmonary vasodilation mediated by ATP-sensitive potassium channels compared to the conscious state
24. Dopamine, dobutamine, and phentolamine effects on pulmonary vascular mechanics
25. Vasoconstriction increases pulmonary nitric oxide synthesis and circulating cyclic GMP
26. Propofol and thiopental attenuate pulmonary vasorelaxant response to ATP-sensitive potassium channel activation in dogs (abstract)
27. Propofol attenuates acetylcholine-induced pulmonary vasorelaxation in dogs: Role of NO and EDHF (abstract)
28. Selective endothelial dysfunction in conscious dogs after cardiopulmonary bypass