Role of ribosome in sequence-specific regulation of membrane targeting and translocation of P-glycoprotein signal-anchor transmembrane segments

Journal of Cell Science

Volumn 113, Issue 14, 2000, Pages 2545-2555

  Zhang, J T ^a   Han, E ^a   Liu, Y ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

P glycoprotein; Ribosome; Signal anchor; Topogenesis

Indexed keywords

AMINO ACID; GLYCOPROTEIN P; MEMBRANE PROTEIN; PLANT EXTRACT; PROTEIN SUBUNIT; SECRETORY PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BIOGENESIS; CELL FREE SYSTEM; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING; RABBIT; RETICULOCYTE LYSATE; RIBOSOME; SIGNAL TRANSDUCTION; WHEAT GERM;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL-FREE SYSTEM; GLYCOSYLATION; INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MUTATION; P-GLYCOPROTEIN; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RIBOSOMES;

ORYCTOLAGUS CUNICULUS; TRITICUM AESTIVUM;

EID: 0033852404     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. SecA interacts with secretory proteins by recognizing the positive charge at the amino terminus of the signal peptide in Escherichia coli
2. Charged residues are major determinants of the transmembrane orientation of a signal-anchor sequence
3. Membrane topology of multidrug resistance protein expressed in Escherichia coli. N-terminal domain
4. Intracellular protein topogenesis
5. Biogenesis of polytopic membrane proteins: Membrane segments assemble within translocation channels prior to membrane integration
6. Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes
7. Topology of MDR1-P-glycoprotein as indicated by epitope mapping of monoclonal antibodies to human MDR cells
8. ATP-dependent transport systems in bacteria and humans: Relevance to cystic fibrosis and multidrug resistance
9. Genetic analysis of the multidrug transporter
10. Biochemistry of multidrug resistance mediated by the multidrug transporter
11. Mechanism involved in generating the carboxyl-terminal half topology of P-glycoprotein
12. Predicting the orientation of eukaryotic membrane-spanning proteins
13. Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol
14. Regulation of protein biogenesis at the endoplasmic reticulum membrane
15. A transmembrane form of the prion protein in neurodegenerative disease
16. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum
17. ABC transporters: from microorganisms to man
18. Membrane topology of P-glycoprotein as determined by epitope insertion: transmembrane organization of the N-terminal domain of mdr3
19. Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration
20. Multidrug resistance: Molecular mechanisms and clinical relevance
21. Structural requirements for membrane assembly of proteins spanning the membrane several times
22. Membrane topology of a cysteine-less mutant of human P-glycoprotein
23. Unusual topogenic sequence directs prion protein biogenesis
24. Wheat germ cytoplasmic ribosomes. Structure of ribosomal subunits and localization of N6,N6-dimethyladenosine by immunoelectron microscopy
25. Molecular mechanism of membrane protein integration into the endoplasmic reticulum
26. Topology of eukaryotic type II membrane proteins: Importance of N-terminal positively charged residues flanking the hydrophobic domain
27. Isolation of antigenic mimics of MDR1-P-glycoprotein by phage-displayed peptide libraries
28. Epitope mapping of the monoclonal antibody MM12.10 to external MDR1 P-glycoprotein domain by synthetic peptide scanning and phage display technologies
29. Predicting the topology of eukaryotic membrane proteins
30. Evidence for an alternate model of human P-glycoprotein structure and biogenesis
31. Intracellular trafficking of pre-(pro) proteins across RER membrane
32. Identification of a translocated protein segment in a voltage-dependent channel
33. Stop-transfer activity of hydrophobic sequences depends on the translation system
34. Purification and properties of a Met-tRNAf binding factor from wheat germ
35. Initiation factors for protein synthesis from wheat germ
36. Preparation of microsomal membranes for cotranslational protein translocation
37. Role of ribosomes in reinitiation of membrane insertion of internal transmembrane segments in a polytopic membrane protein
38. Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence
39. Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein
40. Sequence requirements for membrane assembly of polytopic membrane proteins: Molecular dissection of the membrane insertion process and topogenesis of the human MDR3 P-glycoprotein
41. Dissection of de novo membrane insertion activities of internal transmembrane segments of ATP-binding-cassette transporters: Toward understanding topological rules for membrane assembly of polytopic membrane proteins
42. Membrane topology of the N-terminal half of the hamster P-glycoprotein molecule
43. Topological determinants of internal transmembrane segments in P-glycoprotein sequences
44. Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation
45. Involvement of cytoplasmic factors regulating the membrane orientation of P-glycoprotein sequences