Identification of two new Pmp22 mouse mutants using large-scale mutagenesis and a novel rapid mapping strategy

Human Molecular Genetics

Volumn 9, Issue 12, 2000, Pages 1865-1871

  Isaacs, Adrian M ^a   Davies, Kay E ^a   Hunter, A Jackie ^b   Nolan, Patrick M ^c   Vizor, Lucie ^c   Peters, Jo ^c   Gale, Davina G ^b   Kelsell, David P ^d   Latham, Ian D ^b   Chase, Jennifer M ^b   Fisher, Elizabeth M C ^e   Bouzyk, Mark M ^b   Potter, Allyson ^a   Masih, Mohan ^a   Walsh, Frank S ^b   Sims, Matthew A ^b   Doncaster, Kim E ^b   Parsons, Claire A ^b   Martin, Jo ^d   Brown, Steven D M ^c   Rastan, Sohaila ^b   Spurr, Nigel K ^b   Gray, Ian C ^b   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN BASIC PROTEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 11; CONTROLLED STUDY; FERTILIZATION IN VITRO; FUNCTIONAL ASSESSMENT; GENE FUNCTION; GENE MAPPING; GENE MUTATION; GENOTYPE; HEREDITARY MOTOR SENSORY NEUROPATHY; HISTOPATHOLOGY; MAMMAL; MOUSE; MOUSE MUTANT; MUTAGENESIS; MYELINATION; NONHUMAN; PERIPHERAL NERVE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TREMOR;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0033852333     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.12.1865     Document Type: Article

References (28)

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11. A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse
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19. Impaired intracellular trafficking is a common disease mechanism of PMP22 point mutations in peripheral neuropathies
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