Vanadate restores glucose 6-phosphate in diabetic rats: A mechanism to enhance glucose metabolism

American Journal of Physiology - Endocrinology and Metabolism

Volumn 279, Issue 2 42-2, 2000, Pages

  Sun, Qian ^a   Sekar, Natesampillai ^a   Goldwaser, Itzhak ^a   Gershonov, Eytan ^a   Fridkin, Mati ^a   Shechter, Yoram ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Insulin resistance; Lipogenicity

Indexed keywords

GLUCOSE; GLUCOSE 6 PHOSPHATE; ISOPHANE INSULIN; PHLORIZIN; PIG INSULIN; STREPTOZOCIN; VANADATE SODIUM;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG MECHANISM; ENZYME ASSAY; GLUCOSE METABOLISM; HORMONE ACTION; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOGENESIS; LIVER; MALE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033851024     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.279.2.e403     Document Type: Article

References (53)

1. Assay of inorganic phosphate, total phosphate and phosphatases
2. Vanadate treatment markedly increases glucose utilization in muscle of insulin resistant fa/fa rats without modifying glucose-transporter expression
3. The role of vanadium in the management of diabetes
4. Tissue-specific correction of lipogenic enzyme gene expression in diabetic rats given vanadate
5. Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats
6. Excessive glucose production, rather than insulin resistance, accounts for hyperglycaemia in recent-onset streptozocin-diabetic rats
7. Regulation of glucose transporter and hexokinase II expression in tissues of diabetic rats
8. Effects of chronic administration of vanadate to the rat on the sensitivity of glycolysis and glycogen synthesis in skeletal muscle to insulin
9. Selectivity of the insulin-like actions of vanadate on glucose and protein metabolism in skeletal muscle
10. Lipogenic enzyme activities and mRNA in rat adipose tissue at weaning
11. Electron paramagnetic studies and insulin-like effects of vanadate in rat adipocytes
12. +) ATPase inhibitor
13. The endocrine pancreas: Diabetes mellitus
14. Glucose 6-phosphate effects on deoxyglucose, glucose and methylglucose transport in rat adipocytes. Evidence for intracellular regulation of sugar transport by glucose metabolite
15. The effects of orthovanadate, vanadyl and peroxides of vanadate on glucose metabolism in skeletal muscle preparations in vitro
16. Glucose stimulation of lipogenic enzyme gene expresion in cultured white adipose tissue. A role for glucose 6-phosphate
17. Long-term acting and orally active vanadyl-methylpicolinate complex with hypoglycemic activity in streptozotocin-induced diabetic rats
18. Insulin-like effects of vanadate on glucokinase activity and fructose 2,6-bisphosphate levels in the liver of diabetic rats
19. Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats
20. Effects of nutrients and hormones on transcriptional and posttranscriptional regulation of fatty acid synthase in rat liver
21. D-glucose-6-phosphate, and D-fructose-6-phosphate
22. Antilipolytic actions of vanadate and insulin in rat adipocytes mediated by distinctly different mechanisms
23. Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats
24. Oral administration of vanadate normalized blood glucose levels in streptozotocin-treated rats: Characterization and mode of action
25. Vanadate normalizes hyperglycemia in two mouse models of non-insulin dependent diabetes mellitus
26. The effect of insulin and glucocorticoids on the synthesis and degradation of phosphoenolpyruvate carboxykinase (GTP) in rat adipose tissue cultured in vitro
27. Vanadate induction of L-type pyruvate kinase mRNA in adult rat hepatocytes in primary culture
28. A simple free fat cell bioassay for insulin
29. Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations
30. Cloning of DNA complementary to rat liver fatty acid synthetase mRNA
31. Physiological regulation of acetyl-CoA carboxylase gene expression: Effects of diet, diabetes, and lactation on acetyl-CoA carboxylase mRNA
32. Hormonal regulation of mouse fatty acid synthase gene transcription in liver
33. Long-term effects of vanadyl treatment on streptozocin-induced diabetes in rats
34. Metabolism of isolated fat cells. I. Effect of hormones on glucose metabolism and lipolysis
35. Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalized in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle
36. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
37. (31)P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus
38. Orally active and long-term-acting insulin-mimetic vanadyl Complex: Bis(picolinato)oxovanadium (IV)
39. Substrate regulation of the glucose transport system in rat skeletal muscle. Characterization and kinetic analysis in isolated soleus muscle and skeletal muscle cells in culture
40. Substrate autoregulation of glucose transport: Hexose 6-phosphate mediates the cellular distribution of glucose transporters
41. Vanadate elevates lipogenicity of starved rat adipose tissue: Mechanism of action
42. Insulin-mimetic effects of vanadate: Possible implications for the future treatment of diabetes
43. Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions
44. Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via nonreceptor protein tyrosine kinases and protein phosphotyrosine phosphatases
45. Effect of depletion of bicarbonate or phosphate ions on insulin action in rat adipocytes
46. Rapid action of insulin and cyclic AMP in the regulation of functional messenger RNA coding for glucokinase in rat liver
47. Levels of translatable mRNA coding for rat liver glucokinase
48. Changes in lipid synthesis in rat adipose tissue during development
49. Antidiabetic action of vanadyl in rats independent of in vivo insulin-receptor kinase activity
50. Metabolism of sheep adipose tissue during pregnancy and lactation. Adaptation and regulation
51. Effect of glucose phosphorylation on the activation by insulin of skeletal muscle glycogen synthase
52. Lipid metabolism
53. Regulation of glucokinase in liver