In vivo measurements of glutamine + glutamate (Glx) and N-acetyl aspartate (NAA) levels in human partial epilepsy

Acta Neurologica Scandinavica

Volumn 102, Issue 3, 2000, Pages 179-188

  Savic, I ^a,c,d   Thomas, A M ^a   Ke, Y ^a   Curran, J ^a   Fried, Itzhak ^a,b   Engel Jr , Jerome ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Epilepsy; Glutamine glutamate; MR spectroscopy; N acetyl aspartate

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; N ACETYLGLUTAMIC ACID;

ADOLESCENT; ADULT; ARTICLE; BRAIN LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; EPILEPTIC FOCUS; FEMALE; FOCAL EPILEPSY; HUMAN; MALE; NEOCORTEX; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TEMPORAL LOBE;

ADOLESCENT; ADULT; ASPARTIC ACID; BIOLOGICAL MARKERS; BRAIN; CASE-CONTROL STUDIES; CREATINE; DIAGNOSIS, DIFFERENTIAL; EPILEPSIES, PARTIAL; FEMALE; GLUTAMIC ACID; GLUTAMINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NEOCORTEX; TEMPORAL LOBE;

EID: 0033848981     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0404.2000.102003179.x     Document Type: Article

References (45)

1. Current concepts: Surgery for seizures
2. Outcome with respect to epileptic seizures
3. A proton magnetic resonance spectroscopy study of focal epilepsy in humans
4. 1H NMR spectra of glutamate in the human brain
5. Absolute concentrations of metabolites in the adult human brain in vivo: Quantification of localized proton MR spectra
6. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy
7. 1H-MR Spektroskopie bei Patienten mit Temporallappenepilepsie
8. 1H NMR Spectroscopyin patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols
9. 1H spectrum of rat brain by two-dimensional shift correlated and J-resolved NMR spectroscopy
10. Localized proton NMR spectroscopy in different regions of the brain in vivo, relaxation times and concentration of cerebral metabolites
11. Comparison of single shot localization methods (STEAM and PRESS) for in vivo proton NMR spectra
12. Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy
13. 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo
14. Metabolite abnormalities in progressive multifocal leucoencephalopathy by proton magnetic resonance spectroscopy
15. Proton MR spectroscopy in patients with seizure disorders
16. Magnetic resonance spectroscopy in temporal lobe epilepsy
17. 1H MRS in vivo
18. Proton magnetic resonance spectroscopy in children with temporal lobe epilepsy
19. Temporal lobe epilepsy: Presurgical localization with proton chemical shift imaging
20. Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.IT
21. Aminohydrolases of brain: Enzymatic hydrolysis of N-acetyl-L-aspartate and other N-acetyl-L-amino acids
22. Phosphorus magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy
23. Proton magnetic spectroscopic imaging in patients with extratemporal epilepsy
24. Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy
25. Excitatory amino acids are elevated in human epileptic cerebral cortex
26. Covariation of free amino acids in human epileptogenic cortex
27. Excitotoxicity. Experimental correlates to human epilepsy
28. Amino acid content of epileptogenic human brain: Focal versus surrounding regions
29. Free amino acids and related compounds in biopsies of human brain
30. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain
31. Measurement of glutamate and glutamine in the medial prefrontal cortex of never-treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy
32. 1H MR spectroscopy and neuropsychologic status of patients with hepatic encephalopathy
33. 1H MR spectroscopy in childhood-onset schizophrenia
34. 1H NMR spectra of human brain
35. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging and quantitative lesion volumetry in Multiple Sclerosis
36. Absolute quantitation of water and metabolites in the human brain. I. Compartments and water
37. Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations
38. Interictal cerebral metabolism of neocortical origin
39. Neuroimaging in patients with seizures of probable frontal lobe origin
40. Localization of extra temporal epileptic foci during ictal single photon emission tomography
41. 1H magnetic resonance spectroscopy in magnetic resonance imaging-negative temporal lobe epilepsy: Different biochemical profile compared with hippocampal sclerosis
42. Symbiosis between in vivo and in vitro NMR spectroscopy: The Creatine, N-acetylaspartate, glutamate and GABA content of the epileptic human brain
43. Proton nuclear magnetic resonance spectroscopy unambiguously identifies neural cell types
44. MRS study of glutamate metabolism in cultured neurons/glia
45. 4-13C]glutamate turnover in human brain