SNX-482: A novel class E calcium channel antagonist from tarantula venom

CNS Drug Reviews

Volumn 6, Issue 2, 2000, Pages 153-173

  Newcomb, Robert ^a   Chen, Xiao Hua ^a   Dean, Robin ^b   Dayanithi, Govindin ^c   Cong, Ruth ^a   Szoke, Balazs ^a   Lemos, Jose ^b   Bowersox, Scott ^a   Miljanich, George ^a  

^a ELAN PHARMACEUTICALS   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c CNRS   (France)

Author keywords

Calcium; Class E calcium channel; Epilepsy; Neurohypophysis; Oxytocin; Premature labor; R type calcium channel; SNX 482; Tarantula; Venom

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; ION CHANNEL; SNX 482; UNCLASSIFIED DRUG; VENOM;

BEHAVIOR; CALCIUM CURRENT; DOSE RESPONSE; DRUG ACTIVITY; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; EPILEPSY; NEUROHYPOPHYSIS; NONHUMAN; PREMATURE LABOR; REVIEW; SEIZURE; SPIDER;

EID: 0033847131     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.2000.tb00143.x     Document Type: Review

References (78)

1. 2+ channel antagonist mibefradil (Ro 40-5967)
2. The α(1E) calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels
3. Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent, and neuropathic pain
4. Hormone release from isolated nerve endings of the rat neurohypophysis
5. Ro 40-5967: A new nondihydropyridine calcium antagonist
6. Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker
7. High affinity block of myocardial L-type calcium channels by the spider toxin ω-Aga-toxin IIIA: Advantages over 1,4-dihydropyridines
8. Differential effects of petit mal anticonvulsants on thalamic neurons: Calcium current reduction
9. Anticonvulsant properties of some calcium antagonists on sound-induced seizures in genetically epilepsy prone rats
10. 2+ channels
11. The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin
12. Functional expression of a rapidly inactivating neuronal calcium channel
13. Reverse phase high performance liquid chromatography of biological peptides: Technical aspects and applications
14. Absence epilepsy in tottering mutant mice is associated with calcium channel defects
15. Three novel types of voltage-dependent calcium channels in rat cerebellar neurons
16. Barbiturates and nifedipine have different and selective effects on calcium currents of mouse DRG neurons in culture: A possible basis for differing clinical actions
17. Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium-channel antagonist, SNX-230 (ω-conopeptide MVIIC)
18. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse
19. Complete amino acid sequence of a new type of neurotoxin from the venom of the spider, Agelena opulenta
20. Toxin-resistant calcium currents in embryonic mouse sensory neurons
21. Molecular determinants of drug binding and action on L-type calcium channels
22. Calcium channel beta subunit heterogeneity: Functional expression of cloned cDNA from heart, aorta and brain
23. Behavioral and anticonvulsant effects of calcium channel toxins in DBA/2 mice
24. Drug action and cellular calcium regulation
25. Antiepileptic drug development program: A cooperative effort of government and industry
26. Isolation and pharmacological characterization of ω-grammatoxin S1A, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses
27. Magnocellular neurons
28. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experiment and clinical observations
29. 1 and beta subunit of high voltage-activated calcium channels in rat brain
30. Genetic and electroencephalographic (EEG) characterization of the tg(4j) and lh(2j) models of absence epilepsy
31. Isoform expression of the voltage dependent calcium channel alpha(1E)
32. Sympatholysis after neuron-specific, N-type, voltage sensitive calcium channel blockade: First demonstration of N-channel function in humans
33. Selective central nervous system calcium channel blockers - A new class of anticonvulsant agents
34. Antagonists of neuronal calcium channels: Structure, function, and therapeutic implications
35. P-type calcium channels blocked by the spider toxin ω-Aga-IVa
36. Beta subunits influence the biophysical and pharmacological differences between P- and Q-type calcium currents expressed in a mammalian cell line
37. Comprehensive analysis of the peptide content of neuronal tissue
38. SNX-325, a novel calcium antagonist from the spider Segestria florentina
39. Selective antagonist of the class E calcium channel from the venom of the tarantula, Hysterocrates gigas
40. The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation
41. Purification and sequence of a presynaptic toxin from Conus geographus venom
42. Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using ω-conotoxin from Conus magus venom
43. Calcium channel diversity and neurotransmitter release: The ω-conotoxins and ω-agatoxins
44. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel
45. Antisense oligonucleotides against alpha(1E) reduce R-type calcium currents in cerebellar granule cells
46. Omega-grammatoxin S1A blocks multiple voltage gated calcium channel subtypes in cultured rat hippocampal neurons
47. Identification of a second region of the beta-subunit involved in regulation of calcium channel inactivation
48. 2+ channel currents in rat cerebellar granule neurons
49. Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels
50. Distinctive biophysical and pharmacological properties of R-type and T-type calcium channels
51. Stable expression of cloned human class B and Class E calcium channels in mammalian cells
52. Stable expression of cloned human B class and E class calcium channels in mammalian cells
53. 1 subunits
54. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold calcium channels with a high affinity for L-type channels in cerebellar granule neurons
55. Structure and functional expression of a member of the low voltage-activated calcium channel family
56. Rat brain expresses a heterogeneous family of calcium channels
57. Functional expression of rat brain cloned alpha(1E) calcium channels in COS-7 cells
58. An inhibitor of the Kv2.1 potassium channel isolated from the venom of the Chilean tarantula
59. Several types of calcium channels mediate glutamatergic synaptic responses to activation of single Thy-1 immunolabeled rat retinal ganglion neurons
60. Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons
61. Voltage gated calcium channels
62. Mechanisms of calcium channel blockade by phenytoin
63. 2+ channel alpha(1E) subunit in islets of Langerhans and kidney
64. Antagonism of synaptosomal calcium channels by subtypes of ω-agatoxins
65. Effect of various calcium channel blockers on three different models of limbic seizures in rats
66. The expression of neuronal voltage-dependent calcium channels in human cerebellum
67. Two types of high-threshold calcium currents inhibited by ω-conotoxin in nerve terminals of rat neurohypophysis
68. Role of Q-type calcium channel in vasopressin secretion from neurohypophyseal terminals of the rat
69. An R-type current in neurohypophyseal terminals preferentially regulates oxytocin secretion
70. Immunochemical identification and subcellular distribution of the alpha-1A subunits of brain calcium channels
71. Experimental selection, quantification and evaluation of antiepileptic drugs
72. Structure and functional characterization of neuronal α(1E) calcium channel subtypes
73. Progress in the development of oxytocin antagonists for use in preterm labor
74. R-type calcium currents evoke transmitter release at a rat central synapse
75. Biochemical properties and subcellular distribution of the neuronal class E calcium channel alpha subunit
76. Dihydropyridine- and neurotoxin-sensitive and insensitive calcium currents in acutely dissociated neurons of the rat central amygdala
77. 2+ channels and their possible counterparts in mammalian CNS neurons