Effects of a cisplatin-chondroitin sulfate A complex in reducing the nephrotoxicity of cisplatin

Archives of Toxicology

Volumn 74, Issue 6, 2000, Pages 300-307

  Zhang, Jing Shi ^a   Imai, Teruko ^a   Otagiri, Masaki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Chondroitin sulfate A complex; Cisplatin; Nephrotoxicity; Pharmacokinetics

Indexed keywords

CHONDROITIN 4 SULFATE; CISPLATIN; CREATININE; UREA;

ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; COLON CANCER; COMPLEX FORMATION; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; KIDNEY CLEARANCE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; UREA NITROGEN BLOOD LEVEL; UTERINE CERVIX CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD UREA NITROGEN; CHONDROITIN SULFATES; CISPLATIN; CREATININE; DRUG CARRIERS; DRUG INTERACTIONS; KIDNEY; KIDNEY DISEASES; MALE; ORGAN SIZE; RATS; RATS, WISTAR;

EID: 0033846386     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000124     Document Type: Article

References (24)

1. 113mIndium as a tracer
2. Plasma platinum levels: Relationship to cisplatin dose and nephrotoxicity
3. Cumulative toxicities from cisplatin therapy and current cytoprotective measures
4. The mechanism of renal clearance of cisplatin (cis-dichlorodiammine platinum II) and its modification by furosemide and probenecid
5. Cisplatin metabolites in plasma, a study of their pharmacokinetics and importance in the nephrotoxic and antitumour activity of cisplatin
6. Mechanism of cis-platinum nephrotoxicity: II. Morphologic observations
7. The role of polymer conjugates in the diagnosis and treatment of cancer
8. Physiological model for the pharmacokinetics of cis-dichlorodiammineplatinum (II) (DDP) in the tumored rat
9. The long-term effect of cisplatin on renal function
10. Alteration of pharmacokinetics and nephrotoxicity of cisplatin by alginates
11. Soluble polymers as targetable drug carriers
12. Insights into potential Cellular mechanisms of cisplatin nephrotoxicity and their clinical application
13. Comparative pharmacokinetics of four platinum cytostatics in rats
14. Pharmacologic modulation of reduced glutathione circadian rhythms with buthionine sulfoximine: Relationship with cisplatin toxicity in mice
15. Intracellular metabolites of cisplatin in the rat kidney
16. Quantitative relationship between pharmacokinetics of unchanged cisplatin and nephrotoxicity in rats: Importance of area under the concentration-time curve (AUC) as the major toxicodynamic determinant in vivo
17. Quantitative subcellular distribution of platinum in rat tissues following i.v. bolus and i.v. infusion of cisplatin
18. Fundamental studies with cisplatin
19. Soluble polymers as carriers of cis-platinum
20. The comparative pharmacokinetics of carboplatin and cisplatin in mice and rats
21. Macromolecular carrier systems for targeted drug delivery: Pharmacokinetic considerations on biodistribution
22. Endogenous glutathione conjugates: Occurrence and biological functions
23. Direct amifostine effect on renal tubule cells in rats
24. Current status of platinum-based antitumor drugs