The epitope detected by cytotoxic T lymphocytes against thymus leukemia (TL) antigen is TAP independent

International Immunology

Volumn 12, Issue 9, 2000, Pages 1217-1225

  Tsujimura, Kunio ^a   Obata, Yuichi ^a   Iwase, Shigeru ^a,b   Matsudaira, Yasue ^a   Ozeki, Satoshi ^a   Takahashi, Toshitada ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

MHC class lb; Thymus leukemia (TL) antigen

Indexed keywords

BETA 2 MICROGLOBULIN; EPITOPE; LEUKEMIA ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TRANSPLANTATION ANTIGEN;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL CLONE; CELL CULTURE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DROSOPHILA MELANOGASTER; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; H2 RESTRICTION; LYMPHOCYTE; LYMPHOCYTE SUBPOPULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TEMPERATURE; THYMOCYTE; THYMUS; TRANSGENE; TRANSGENIC MOUSE;

EID: 0033841895     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.9.1217     Document Type: Article

References (58)

1. Antigen presentation by major histocompatibility complex class I-B molecules
2. Immunogenetics of cell surface antigens of mouse leukemia
3. Tla-region genes and their products
4. Expression of the thymus leukemia antigen in mouse intestinal epithelium
5. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells
6. TL antigen as a transplantation antigen recognized by TL-restricted cytotoxic T cells
7. Positive selection of γδ CTL by TL antigen expressed in the thymus
8. Two types of anti-TL (thymus leukemia) CTL clones with distinct target specificities: Differences in cytotoxic mechanisms and accessory molecule requirements
9. Nonclassical behavior of the thymus leukemia antigen: Peptide transporter-independent expression of a nonclassical class I molecule
10. 2-microglobulin-associated thymus-leukemia antigen is independent of TAP2
11. +) T cells that express αβ T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice
12. Empty and peptide-containing conformers of class I major histocompatibility complex molecules expressed in Drosophila melanogaster cells
13. Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: Abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain
14. Abnormal thymic development, impaired immune function and γδ T cell lymphomas in a TL transgenic mouse strain
15. 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
16. + T cells
17. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy
18. A manual of methods for baculovirus vectors and insect cell culture procedures
19. Cell lines derived from late embryonic stages of Drosophila melanogaster
20. Structural analysis of TL genes of the mouse
21. Cell-surface differentiation in the mouse. Characterization of 'jumping' and 'lineage' antigens using xenogeneic rat monoclonal antibodies
22. b haplotype reveal genetic control of isotype expression
23. Lym11: The H-3 region of mouse chromosome 2 controls a new surface alloantigen
24. b antigens determined with monoclonal antibodies and H-2 mutant mice
25. 2-microglobulin, and peptides on class I MHC folding and assembly in an in vitro translation system
26. Efficient selection for high-expression transfectants with a novel eukaryotic vector
27. Effects of DNA polymerase β gene over-expressed in transgenic Drosophila on DNA repair and recombination
28. Cytotoxic T lymphocytes against the antigen-processing-defective RMA-S tumor cell line
29. RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes
30. An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S.J
31. TAP2-defective RMA-S cells present Sendai virus antigen to cytotoxic T lymphocytes
32. b
33. A simple method to eliminate the antigenicity of surface class I MHC molecules from the membrane of viable cells by acid treatment at pH 3
34. Conserved lipid and peptide presentation functions of nonclassical class I molecules
35. Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class lb antigen
36. A nonpolymorphic major histocompatibility complex class lb molecule binds a large array of diverse self-peptides
37. H2-M3, a full-service class IB histocompatibility antigen
38. Thymus-leukemia antigen interacts with T cells and self-peptides
39. Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex
40. Antigen-selected T-cell receptor diversity and self-nonself homology
41. b antigens on cells lacking a functional Tap-2 transporter
42. The CD1 family: A third lineage of antigen-presenting molecules
43. CD1-mediated immune responses to glycolipids
44. + T cells
45. CD1-restricted T cell recognition of microbial lipoglycan antigens
46. Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells
47. Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol
48. CDR3 length in antigen-specific immune receptors
49. The nature of major histocompatibility complex recognition by γδ T cells
50. Recognition by γ/δ T cells
51. Antigen recognition by class I-restricted T lymphocytes
52. Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule
53. Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells
54. Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2
55. Role of endogenous peptide in human alloreactive cytotoxic T cell responses
56. On the nature of peptides involved in T cell alloreactivity
57. Peptide-independent recognition by alloreactive cytotoxic T lymphocytes (CTL)