Positive selection of γδ CTL by TL antigen expressed in the thymus

Journal of Experimental Medicine

Volumn 184, Issue 6, 1996, Pages 2175-2184

  Tsujimura, Kunio ^a   Takahashi, Toshitada ^a   Morita, Akimichi ^a,b   Hasegawa Nishiwaki, Hitomi ^a   Iwase, Shigeru ^a,c   Obata, Yuichi ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FLOW CYTOMETRY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; SPLEEN CELL; THYMUS; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD8; BASE SEQUENCE; CLONE CELLS; GRAFT REJECTION; IMMUNITY, CELLULAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTE TRANSFUSION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SEQUENCE HOMOLOGY, AMINO ACID; SKIN TRANSPLANTATION; T-LYMPHOCYTES, CYTOTOXIC; THYMUS GLAND;

EID: 0030470570     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.6.2175     Document Type: Article

References (44)

1. Klein, J. 1986. Natural History of the Major Histocompatibility Complex. John Wiley & Sons, Inc., New York. 775 pp.
2. Shawar, S.M., J.M. Vyas, J.R. Rodgers, and R.R. Rich. 1994. Antigen presentation by major histocompatibility complex class I-B molecules. Annu. Rev. Immunol. 12:839-880.
3. Simister, N.E., and K.E. Mostov. 1989. An Fc receptor structurally related to MHC class I antigens. Nature (Lond.). 337: 184-187.
4. Haas, W., P. Pereira, and S. Tonegawa. 1993. Gamma/delta cells. Annu. Rev. Immunol. 11:637-685.
5. Bluestone, J.A., R. Khattri, R. Sciammas, and A.I. Sperling. 1995. TCRγδ cells: a specialized T-cell subset in the immune system. Annu. Rev. Cell Dev. Biol. 11:307-353.
6. Chen, Y.-T., Y. Obata, E. Stockert, T. Takahashi, and L.J. Old. 1987. Tla-region genes and their products. Immunol. Res. 6:30-45.
7. Old, L.J., and E. Stockert. 1977. Immunogenetics of cell surface antigens of mouse leukemia. Annu. Rev. Genet. 11:127-160.
8. Boyse, E.A., L.J. Old, and S. Luell. 1963. Antigenic properties of experimental leukemias. II. Immunological studies in vivo with C57BL/6 radiation-induced leukemias. J. Natl. Cancer Inst. 31:987-995.
9. Hershberg, R., P. Eghtesady, B. Sydora, K. Brorson, H. Cheroutre, R. Modlin, and M. Kronenberg. 1990. Expression of the thymus leukemia antigen in mouse intestinal epithelium. Proc. Natl. Acad. Sci. USA. 87:9727-9731.
10. Wu, M., L. Van Kaer, S. Itohara, and S. Tonegawa. 1991. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. J. Exp. Med. 174:213-218.
11. Hamasima, N., T. Takahashi, O. Taguchi, Y. Nishizuka, E. Stocken, L.J. Old, and Y. Obata. 1989. Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain. Proc. Natl. Acad. Sci. USA. 86:7995-7999.
12. Morita, A., T. Takahashi, E. Stockert, E. Nakayama, T. Tsuji, Y. Matsudaira, L.J. Old, and Y. Obata. 1994. TL antigen as a transplantation antigen recognized by TL-restricted cytotoxic T cells. J. Exp. Med. 179:777-784.
13. Obata, Y., O. Taguchi, Y. Matsudaira, H. Hasegawa, N. Hamasima, and T. Takahashi. 1991. Abnormal thymic development, impaired immune function and 78 T cell lymphomas in a TL transgenic mouse strain. J. Exp. Med. 174:351-362.
14. Obata, Y., Y.-T. Chen, E. Stockert, and L.J. Old. 1985. Structural analysis of TL genes of the mouse. Proc. Natl. Acad. Sci. USA. 82:5475-5479.
15. - strains. J. Exp. Med. 162:1134-1148.
16. Ledbetter, J.A., and L.A. Herzenberg. 1979. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47:63-90.
17. Dialynas, D.P., Z.S. Quan, K.A. Wall, A. Pierres, J. Quintáns, M.R. Loken, M. Pierres, and F.W. Fitch. 1983. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131:2445-2451.
18. Kubo, R.T., W. Born, J.W. Kappler, P. Marrack, and M. Pigeon. 1989. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142:2736-2742.
19. Itohara, S., N. Nakanishi, O. Katiagawa, R. Kubo, and S. Tonegawa. 1989. Monoclonal antibodies specific to native murine T-cell receptor γδ: analysis of γδ T cells during thymic ontogeny and in peripheral lymphoid organs. Proc. Natl. Acad. Sci. USA. 86:5094-5098.
20. Leo, O., M. Foo, D.H. Sachs, L.E. Samelson, and J.A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA. 84: 1374-1378.
21. Takagaki, Y., A. DeCloux, M. Bonneville, and S. Tonegawa. 1989. Diversity of γδ T-cell receptors on murine intestinal intraepithelial lymphocytes. Nature (Lond.). 339:712-714.
22. Reilly, E.B., D.M. Kranz, S. Tonegawa, and H.N. Eisen. 1986. A functional γ gene formed from known γ-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes. Nature (Lond.). 321:878-880.
23. + lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med. 173:471-481.
24. Lefrancois, L. 1991. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 147:1746-1751.
25. Bandeira, A., S. Itohara, M. Bonneville, O. Burlen-Defranoux, T. Mota-Santos, A. Coutinho, and S. Tonegawa. 1991. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor γδ. Proc. Natl. Acad. Sci. USA. 88:43-47.
26. Pereira, P., D. Gerber, S.Y. Huang, and S. Tonegawa. 1995. Ontogenic development and tissue distribution of Vγ1-expressing γ/δ T lymphocytes in normal mice. J. Exp. Med. 182:1921-1930.
27. Whetsell, M., R.L Mosley, L. Whetsell, F.V. Schaefer, K.S. Miller, and J.R. Klein. 1991. Rearrangement and junctional-site sequence analyses of T-cell receptor gamma genes in intestinal intraepithelial lymphocytes from murine athymic chimeras. Mol. Cell. Biol. 11:5902-5909.
28. Iwamoto, A., F. Rupp, P.S. Ohashi, C.L. Walker, H. Pircher, R. Joho, H. Hengartner, and T.W. Mak. 1986. T cell-specific γ genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes. J. Exp. Med. 163: 1203-1212.
29. Lafaille, J.J., A. DeCloux, M. Bonneville, Y. Takagaki, and S. Tonegawa. 1989. Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell. 59:859-870.
30. Pereira, P., D. Gerber, A. Regnault, S.Y. Huang, V. Hermitte, A. Coutinho, and S. Tonegawa. 1996. Rearrangement and expression of Vγ1, Vγ2 and Vγ3 TCR γ genes in C57BL/6 mice. Int. Immunol. 8:83-90.
31. 2-microglobulin-associated thymus-leukemia antigen is independent of TAP2. Eur. J. Immunol. 25:1001-1007.
32. Steinmetz, M., A. Winoto, K. Minard, and L. Hood. 1982. Clusters of genes encoding mouse transplantation antigens. Cell. 28:489-498.
33. Boyse, E.A., L. Flaherty, E. Stockert, and L.J. Old. 1972. Histocompatibility attributable to genes near H-2 that are not revealed by hemagglutination or cytotoxicity tests. Transplantation (Baltimore). 13:431-432.
34. Teitell, M., M.F. Mescher, C.A. Olson, D.R. Littman, and M. Kronenberg. 1991. The thymus leukemia antigen binds human and mouse CD8. J. Exp. Med. 174:1131-1138.
35. lck in T cell signaling and thymocyte development. Adv. Immunol. 56:151-178.
36. Takagaki, Y., N. Nakanishi, I. Ishida, O. Kanagawa, and S. Tonegawa. 1989. T cell receptor-γ and -δ genes preferentially utilized by adult thymocytes for the surface expression. J. Immunol. 142:2112-2121.
37. Obata, Y., Y. Satta, K. Moriwaki, T. Shiroishi, H. Hasegawa, T. Takahashi, and N. Takahata. 1994. Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex. Proc. Natl. Acad. Sci. USA. 91:6589-6593.
38. Townsend, A., and H. Bodmer. 1989. Antigen recognition by class I-restricted T lymphocytes. Annu. Rev. Immunol. 7: 601-624.
39. + T cells. Nature (Lond.). 372: 691-694.
40. Schild, H., N. Mavaddat, C. Litzenberger, E.W. Ehrich, M.M. Davis, J.A. Bluestone, L. Matis, R.K. Draper, and Y.-H. Chien. 1994. The nature of major histocompatibility complex recognition by γδ T cells. Cell. 76:29-37.
41. Jackson, M.R., E.S. Song, Y. Yang, and P.A. Peterson. 1992. Empty and peptide-containing conformers of class I major histocompatibility complex molecules expressed in Drosophila melanogaster cells. Proc. Natl. Acad. Sci. USA. 89:12117-12121.
42. Holcombe, H.R., A.R. Castaño, H. Cheroutre, M. Teitell, J.K. Maher, P.A. Peterson, and M. Kronenberg. 1995. Non-classical behavior of the thymus leukemia antigen: peptide transporter-independent expression of a nonclassical class I molecule. J. Exp. Med. 181:1433-1443.
43. Sharma, P., S. Joyce, K.A. Chorney, J.W. Griffith, R.H. Bonneau, F.D. Wilson, C.A. Johnson, R.A. Flavell, and M.J. Chorney. 1996. Thymus-leukemia antigen interacts with T cells and self-peptides. J. Immunol. 156:987-996.
44. Joyce, S., and S.G. Nathenson. 1994. Methods to study peptides associated with MHC class I molecules. Curr. Opin. Immunol. 6:24-31.