Endogenous mediators in emergency department patients with presumed sepsis: Are levels associated with progression to severe sepsis and death?

Annals of Emergency Medicine

Volumn 35, Issue 1, 2000, Pages 26-34

  Terregino, Carol A ^a   Lopez, Bernard L ^b   Karras, David J ^c   Killian, Anthony J ^a   Arnold, Gerald K ^a  

^a Department of Anesthesiology   (United States)

^b THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^c TEMPLE UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CYTOKINE RELEASE; DEATH; DISEASE COURSE; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MALE; MEDIATOR RELEASE; MULTICENTER STUDY; PRIORITY JOURNAL; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 0033838816     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-0644(00)70101-6     Document Type: Article

References (48)

1. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. ACCP/SCCM Consensus Conference
2. Sepsis and multiple organ dysfunction syndrome: A clinical-mechanistic overview
3. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome
4. Shock and tissue injury induced by recombinant human cachectin
5. Tumor necrosis factor mediates endotoxic effects in mice
6. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits
7. Increased circulating nitrogen oxides after human tumor immunotherapy: Correlation with toxic hemodynamic changes
8. Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin
9. NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, reverses interleukin-2-induced hypotension
10. Prognostic values of serum cytokines in septic shock
11. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality
12. Patterns of cytokine evolution (tumor necrosis factor-α and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma
13. Sepsis and serum cytokine concentrations
14. Prolonged elevation of interleukin-8 and interleukin-6 concentrations in plasma and of leukocyte interleukin-8 mRNA levels during septicemic and localized Pseudomonas pseudomallei infection
15. Plasma levels of cytokines in primary septic shock in humans: Correlation with disease severity
16. Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit
17. L-arginine: Nitric oxide pathway in endotoxemia and human septic shock
18. Evidence of increased nitric oxide production in patients with the sepsis syndrome
19. Nitrogen oxide levels in patients after trauma and during sepsis
20. Pilot study of cytokines in emergency department patients with systemic inflammatory response syndrome
21. Plasma cytokine determinations in emergency department patients as a predictor of bacteremia and infectious disease severity
22. Utility of serum interleukin-6 for diagnosis of invasive bacterial disease in children
23. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: What we do and do not know about cytokine regulation
24. A method of comparing the areas under receiver operating characteristic curves derived from the same cases
25. The cytokine network in the critically ill
26. Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure
27. Interleukin-10 production during septicaemia
28. Tumor necrosis factor in sepsis: Mediator of multiple organ failure or essential part of host defense?
29. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
30. Detection of circulating tumor necrosis factor after endotoxin administration
31. Anti-interleukin-6 antibody treatment improves survival during gut-derived sepsis in a time-dependent manner by enhancing host defense
32. The L-arginine-nitric oxide pathway. Mechanisms of disease
33. Nitric oxide: A physiologic messenger
34. Measurements of total plasma nitrite and nitrate in pediatric patients with the systemic inflammatory response syndrome
35. Plasma nitrite and nitrate concentrations and multiple organ failure in pediatric sepsis
36. Plasma nitric oxide levels in newborn infants with sepsis
37. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhlL-1ra Sepsis Syndrome Study Group
38. Double-blind randomized controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
39. Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study
40. Effects of a nitric oxide synthase inhibitor in humans with septic shock
41. Prolonged inhibition of nitric oxide synthesis in severe septic shock: A clinical study
42. Serum levels of end products of nitric oxide synthesis correlate positively with tumor necrosis factor α and negatively with body temperature in patients with postoperative abdominal sepsis
43. The natural history of the systemic inflammatory response syndrome (SIRS)
44. Dear SIRS, I'm sorry to say that I don't like you...
45. To SIRS with love
46. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients
47. Circulating cytokine concentrations and outcome prediction in intensive care unit patients: Still the tip of the iceberg?
48. Release of soluble receptor for tumor necrosis factor in clinical sepsis and experimental endotoxemia