Purification and some properties of two enzymes from rat liver cytosol that catalyze carbonyl reduction of 6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4- dione, a metabolite of 3-tert-butyl-4-hydroxyanisole

Archives of Biochemistry and Biophysics

Volumn 361, Issue 2, 1999, Pages 207-214

  Tajima, Kazuo ^a   Hashizaki, Mari ^a   Yamamoto, Kenji ^a   Narimatsu, Shizuo ^b   Mizutani, Tamio ^c  

^a HOKURIKU UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Cytosol; Inhibitors; Metabolism; Purification; Rat liver; Reductases; Stereoselectivity; Steroids; Substrate specificity

Indexed keywords

4 CHLOROMERCURIBENZOIC ACID; BUTYLATED HYDROXYANISOLE; CARBONYL REDUCTASE; DICOUMAROL; PHENOBARBITAL; PYRAZOLE; QUERCITRIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME METABOLISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ISOELECTRIC POINT; LIVER CYTOSOL; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; STEREOCHEMISTRY;

EID: 0033555130     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1998.0986     Document Type: Article

References (42)

1. Felsted R. L., Bachur N. R. Drug Metab. Rev. 11:1980;1-60.
2. Ikeda M., Hattori H., Ohmori S. Biochem. Pharmacol. 33:1984;3957-3961.
3. Jakoby W. B., Ziegler D. M. J. Biol. Chem. 265:1990;20715-20718.
4. Wermuth B. Enzymology of Carbonyl Metabolism: Aldehyde Dehydrogenase, Aldo/Keto Reductase, and Alcohol Dehydrogenase. 1985;A. R. Liss, New York. p. 209-230.
5. Maser E. Biochem. Pharmacol. 49:1995;421-440.
6. Wermuth B., Bohren K. M., Heinemann G., von Wartburg J.-P., Gabbay K. H. J. Biol. Chem. 263:1988;16185-16188.
7. Bohren K. M., Bullock B., Wermuth B., Gabbay K. H. J. Biol. Chem. 264:1989;9547-9551.
8. Persson B., Krook M., Jörnvall H. Eur. J. Biochem. 200:1991;537-543.
9. Jörnvall H., Persson B., Krook M., Atrian S., Gonzàlez-Duarte R., Jeffery J., Ghosh D. Biochemistry. 34:1995;6003-6013.
10. Penning T. M., Bennett M. J., Hoog S. S., Schlegel B. P., Jez J. M., Lewis M. Steroids. 62:1997;101-111.
11. Nishinaka T., Kinoshita Y., Terada N., Terada T., Mizoguchi T., Nishihara T. Enzyme. 46:1992;221-228.
12. Oritani H., Deyashiki Y., Nakayama T., Hara A., Sawada H., Matsuura K., Bunai Y., Ohya I. Arch. Biochem. Biophys. 292:1992;539-547.
13. Nakanishi M., Deyashiki Y., Nakayama T., Sato K., Hara A. Biochem. Biophys. Res. Commun. 194:1993;1311-1316.
14. Ito N., Hirose M. Adv. Cancer Res. 53:1989;247-302.
15. Verhagen H., Schilderman P. A. E. L., Kleinjans J. C. S. Chem.-Biol. Interact. 80:1991;109-134.
16. Tajima K., Hashizaki M., Yamamoto K., Mizutani T. Drug Metab. Disp. 20:1992;816-820.
17. Tajima K., Hashizaki M., Yamamoto K., Mizutani T. Drug Metab. Disp. 22:1994;815-818.
18. Laemmli U. K. Nature. 227:1970;680-685.
19. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. J. Biol. Chem. 193:1951;265-275.
20. Wermuth B. J. Biol. Chem. 256:1981;1206-1213.
21. Ernster L., Danielson L., Ljunggren M. Biochim. Biophys. Acta. 58:1962;171-188.
22. Sawada H., Hara A., Nakayama T., Kato F. J. Biochem. 87:1980;1153-1165.
23. Ahmed N. K., Felsted R. L., Bachur N. R. J. Pharmacol. Exp. Ther. 209:1979;12-19.
24. Nakayama T., Hara A., Yashiro K., Sawada H. Biochem. Pharmacol. 34:1985;107-117.
25. Sawada H., Hara A., Kato F., Nakayama T. J. Biochem. 86:1979;871-881.
26. Usui S., Hara A., Nakayama T., Sawada H. Biochem. J. 223:1984;697-705.
27. Maser E., Netter K. J. Biochem. Pharmacol. 38:1989;3049-3054.
28. Nakayama T., Hara A., Sawada H. Arch. Biochem. Biophys. 217:1982;564-573.
29. Pietruszko R., Chen F.-F. Biochem. Pharmacol. 25:1976;2721-2725.
30. Nakayama T., Hara A., Sawada H. J. Biochem. 98:1985;1131-1133.
31. Hara A., Deyashiki Y., Nakagawa M., Nakayama T., Sawada H. J. Biochem. 92:1982;1753-1762.
32. Felsted R. L., Richter D. R., Jones D. M., Bachur N. R. Biochem. Pharmacol. 29:1980;1503-1516.
33. Askonas L. J., Ricigliano J. W., Penning T. M. Biochem. J. 278:1991;835-841.
34. Penning T. M., Mukharji I., Barrows S., Talalay P. Biochem. J. 222:1984;601-611.
35. Deyashiki Y., Ohshima K., Nakanishi M., Sato K., Matsuura K., Hara A. J. Biol. Chem. 270:1995;10461-10467.
36. Penning T. M., Pawlowski J. E., Schlegel B. P., Jez J. M., Lin H.-K., Hoog S. S., Bennett M. J., Lewis M. Steroids. 61:1996;508-523.
37. Penning T. M., Smithgall T. E., Askonas L. J., Sharp R. B. Steroids. 47:1986;221-247.
38. Hara A., Karia K., Nakamura M., Nakayama T., Sawada H. Arch. Biochem. Biophys. 249:1986;225-236.
39. Tanaka M., Ohno S., Adachi S., Nakajin S., Shinoda M., Nagahama Y. J. Biol. Chem. 267:1992;13451-13455.
40. Flynn T. G., Green N. C. Weiner H., Crabb D. W., Flynn T. G. Enzymology and Molecular Biology of Carbonyl Metabolism 4. 1993;328-257 Plenum, New York.
41. Nakanishi M., Deyashiki Y., Ohshima K., Hara A. Eur. J. Biochem. 228:1995;381-387.
42. Jez J. M., Flynn T. G., Penning T. M. Biochem. Pharmacol. 54:1997;639-647.