Electrophysiological characteristics of antiarrhythmic potential of acrophyllidine, a furoquinoline alkaloid isolated from Acronychia halophylla

Drug Development Research

Volumn 50, Issue 2, 2000, Pages 170-185

  Chang, Gwo Jyh ^a   Wu, Mei Hwan ^a   Chen, Wen Pin ^a   Kuo, Sheng Chu ^b   Su, Ming Jai ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Acronychia halophylla; Acrophyllidine; Action potential; Cardiac arrhythmia; Cardiac myocytes; Ionic currents

Indexed keywords

ACRONYCHIA HALOPHYLLA EXTRACT; ACROPHYLLIDINE; ALKALOID DERIVATIVE; ANTIARRHYTHMIC AGENT; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART VENTRICLE ARRHYTHMIA; ISOLATED HEART; MALE; NONHUMAN; RAT; REPERFUSION INJURY;

EID: 0033836836     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2299(200006)50:2<170::AID-DDR7>3.0.CO;2-W     Document Type: Article

References (47)

1. + currents in isolated adult rat ventricular myocytes
2. Better antiarrhythmics? Development of antiarrhythmic drugs selective for ischemia-dependent arrhythmias
3. Lidocaine block of cardiac sodium channels
4. + current blocker
5. Acute coronary artery occlusion-reperfusion-induced arrhythmias in rats, dogs, and pigs: Antiarrhythmic evaluation of quinidine, procainamide and lidocaine
6. Shortening of the action potential and reduction of pacemaker activity by lidocaine, quinidine and procainamide in sheep cardiac Purkinje fibers: An effect on Na or K currents?
7. Electrophysiological mechanisms for antiarrhythmic efficacy and positive inotropy of liriodenine, a natural aporphine alkaloid from Fissistigma glaucescens
8. Skimmianine and related furoquinolines function as antagonists of 5-hydroxytryptamine receptors in animals
9. Evidence for two components of sodium channel block by lidocaine in isolated cardiac myocytes
10. Ischaemia-induced and reperfusion-induced arrhythmias differ in their sensitivity to potassium: Implications for mechanisms of initiation and maintenance of ventricular fibrillation
11. Mortality and morbidity in patients receiving encainide, flecainide, or placebo: The cardiac arrhythmia suppression trial
12. Two types of transient outward currents in adult human atrial cells
13. Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion: Studies on isolated canine ventricular tissues
14. 2+ currents in determining conduction
15. In vivo assessment of class III antiarrhythmic agents and their antiarrhythmic activity
16. Comparison of potassimn currents in rabbit atrial and ventricular cells
17. + channels by antiarrhythmic drugs, neurotransmitters and hormones
18. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches
19. Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
20. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
21. Development of class III antiarrhythmic agents
22. The antiallergic activities of synthetic acrophylline and acrophyllidine
23. Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes
24. Electrophysiological basis for arrhythmias caused by acute ischemia. Role of subendocardium
25. Haemodynamic effects of newer antiarrhythmic agents
26. Early outward current in rat ventricular cells
27. Acrophylline and acrophyllidine: Two new alkaloids from Acronychia halophylla
28. Reperfusion-induced arrhythmias: Mechanisms and prevention
29. A uniform enzymatic method for the dissociation of myocytes from heart and stomach of vertebrates
30. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure
31. Action potential, membrane currents and force of contraction in mammalian heart muscle fibers treated with quinidine
32. Sudden cardiac death while wearing a Holter monitor
33. Sudden unexplained death in patients with congestive heart failure: A second frontier
34. Electrophysiologic mechanisms underlying arrhythmias due to reperfusion of ischemic myocardium
35. Electrophysiology and pharmacology of cardiac arrhythmias. VI. Cardiac effects of verapamil
36. Modulation of potassium channels by antiarrhythmic and antihypertensive drugs
37. Cardiodepressive effects of antiarrhythmic drugs
38. Control of cardiac arrhythmia by selective lengthening of repolarization: Therapeutic considerations and clinical observations
39. + channel blocking actions of flecainide compared with those ofpropafenone and quinidine in adult rat ventricular myocytes
40. + channel cDNAs from human ventricle
41. Influence of tedisamil on initiation and maintenance of ventricular fibrillation: Chemical defibrillation by I(to) blockade?
42. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction: The SWORD Investigators, survival with oral d-sotalol
43. Effects of berberine on cardiac arrhythmias following coronary artery occlusion and its mechanisms
44. Antiarrhythmic drugs
45. Electrophysiological basis for antiarrhythmic efficacy, positive inotropy and low proarrhythmic potential of (-)- caryachine
46. 2+ channel blockers