Virological and immunological characteristics of HIV treatment failure

AIDS

Volumn 14, Issue 12, 2000, Pages 1767-1774

  Kaufmann, Daniel ^a   Muñoz, Miguel ^a   Bleiber, Gabriela ^a   Fleury, Sylvain ^a   Lotti, Barbara ^b   Martinez, Raquel ^a   Pichler, Werner ^b   Meylan, Pascal ^a   Telenti, Amalio ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Drug resistance; Fitness; Immune recovery; Infectivity; MDR HIV; Replication

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR; GAG PROTEIN; GAMMA INTERFERON; KI 67 ANTIGEN; PROTEINASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ADULT; AGED; ARTICLE; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TREATMENT FAILURE; VIRUS REPLICATION;

ADULT; AGED; CD4 LYMPHOCYTE COUNT; DRUG RESISTANCE, MULTIPLE; FEMALE; FLOW CYTOMETRY; HIV; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HUMANS; MALE; MIDDLE AGED; TIME FACTORS; TREATMENT FAILURE; VIRAL LOAD; VIRUS REPLICATION;

EID: 0033834920     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200008180-00012     Document Type: Article

References (21)

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2. HIV treatment failure: Testing for HIV resistance in clinical practice
3. Heterogeneity of response to antiretroviral therapy
4. CD4-cell count in HIV-1 infected individuals remaining viraemic with highly active antiretroviral therapy (HAART)
5. Detection of low HIV-1 RNA levels in plasma
6. Centrifugal enhancement of retroviral mediated gene transfer
7. Contribution of protease and reverse transcriptase drug-resistance mutations to HIV infectivity, replication and protein maturation
8. Turnover of CD4+ and CD8+ T lymphocytes in HIV-1 infection as measured by Ki-67 antigen
9. Limited CD4+ T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy
10. HAART in HIV-infected patients: Restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T cell reconstitution whereas improvement in delayed type hypersensitivity is related to a decrease in viremia
11. Polymorphism of HIV-1 Gag p7/p1 and p1/p6 cleavage sites. Clinical significance and implications for resistance to protease inhibitors
12. Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protease and Gag coevolution in protease inhibitor-treated patients
13. HIV RNA and CD4 cell count response to protease inhibitor in an urban AIDS clinic: Response to initial and salvage therapy
14. Rapid decline in detectability of HIV-1 resistance mutations after stopping therapy
15. Interruption of reverse transcriptase inhibitors or a swich from reverse transcriptase to protease inhibitors resulted in a fast reappearane of virus strains with a reverse transcriptase inhibitor-sensitive genotype
16. Mega-HAART, resistance and drug holidays
17. Lack of fitness of protease inhibitor-resistant HIV-1 in vivo
18. Improvement in CD4 T-cell count in spite of virological failure. Role of thymic output
19. Changes in thymic function with age and during the treatment of HIV infection
20. Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy