Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but also delays development

Genetics

Volumn 156, Issue 1, 2000, Pages 219-227

  Parsch, J ^a   Russell, J A ^a   Beerman, I ^a   Hartl, D L ^a   Stephan, W ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE;

ARTICLE; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; LIFE CYCLE; NONHUMAN; PRIORITY JOURNAL; UNTRANSLATED REGION;

3' UNTRANSLATED REGIONS; ALCOHOL DEHYDROGENASE; ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; DNA PRIMERS; DROSOPHILA MELANOGASTER; FEMALE; GENES, INSECT; GENES, REGULATOR; LARVA; MALE; SEQUENCE DELETION; TISSUE DISTRIBUTION;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0033832539     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Molecular population genetics of the alcohol dehydrogenase gene region of Drosophila melanogaster
2. Speculations on the subject of alcohol dehydrogenase and its properties in Drosophila and other flies
3. Is the fast/slow allozyme variation at the Adh locus of Drosophila melanogaster an ancient balanced polymorphism?
4. Alcohol dehydrogenase in Drosophila: Isolation and characterization of messenger RNA and cDNA clone
5. Molecular analysis of an allozyme cline: Alcohol dehydrogenase in Drosophila melanogaster on the east coast of North America
6. Adaptation to alcoholic fermentation in Drosophila: A parallel selection imposed by environmental ethanol and acetic acid
7. Use of in vitro mutagenesis to analyze the difference in Adh expression associated with the allozyme polymorphism in Drosophila melanogaster
8. The role of specific enhancer-promoter interactions in the Drosophila Adh promoter switch
9. Translational regulation in development
10. Structural analysis of the ADHs electromorph of Drosophila melanogaster
11. Toward an understanding of evolutionary potential
12. Regulatory and structural genes for lysozymes of mice
13. Limits of adaptation: The evolution of selective neutrality
14. A test of neutral molecular evolution based on nucleotide data
15. Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster
16. Inferring the evolutionary histories of the Adh and Adh-dup loci in Drosophila melanogaster from patterns of polymorphism and divergence
17. The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split complex gene expression
18. The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of Enhancer of split complex transcripts
19. The effect of an intronic polymorphism on alcohol dehydrogenase expression in Drosophila melanogaster
20. Associations between DNA sequence variation and variation in expression of the Adh gene in natural populations of Drosophila melanogaster
21. Use of P-element-mediated transformation to identify the molecular basis of naturally occurring variants affecting Adh expression in Drosophila melanogaster
22. The Drosophila gene Bearded encodes a novel small protein and shares 3' UTR sequence motifs with multiple Enhancer of split complex genes
23. Protein measurements with the Folin phenol reagent
24. Genetic control of alcohol dehydrogenase levels in Drosophila
25. Alcohol tolerance, ADH activity, and ecological niche of Drosophila species
26. Alcohol dehydrogenase and glycerol-3-phosphate dehydrogenase clines in Drosophila melanogaster on different continents
27. MacAnova: An interactive program for statistical analysis and matrix algebra, v. 4.06
28. Site-directed mutations reveal long-range compensatory interactions in the Adh gene of Drosophila melanogaster
29. A highly conserved sequence in the 3'-untranslated region of the Drosophila Adh gene plays a functional role in Adh expression
30. Position-independent germline transformation in Drosophila using a cuticle pigmentation gene as a selectable marker
31. A stable genomic source of P element transposase in Drosophila melanogaster
32. Control of messenger RNA stability in higher eukaryotes
33. Genetic transformation of Drosophila with transposable element vectors
34. Overexpression Beadex mutations and loss-of-function heldup-a mutations in Drosophila affect the 3' regulatory and coding components, respectively, of the Dlmo gene
35. An experimental test for lineage-specific position effects on alcohol dehydrogenase (Adh) genes in Drosophila
36. Transposition of cloned P-elements into Drosophila germ line chromosomes
37. The intracellular localization of messenger RNAs
38. Molecular dissection of a major gene effect on a quantitative trait: The level of alcohol dehydrogenase expression in Drosophila melanogaster
39. Molecular evolution of the alcohol dehydrogenase genes in the genus Drosophila
40. Biochemical evolution