Multi-cellular activation in vivo by endotoxin in humans - Limited protection by adenosine infusion

Thrombosis and Haemostasis

Volumn 84, Issue 3, 2000, Pages 381-387

  Li, N ^a   Soop, A ^a   Sollevi, A ^a   Hjemdahl, P ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adenosine; Endotoxin; Leukocytes; Platelet leukocyte aggregates; Platelets

Indexed keywords

ADENOSINE; CD11 ANTIGEN; ELASTASE; ENDOTOXIN; PADGEM PROTEIN; THROMBIN;

ADULT; ARTICLE; CELL ACTIVATION; CELL PROTECTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE AGGREGATION; LEUKOCYTOSIS; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

EID: 0033832441     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614032     Document Type: Article

References (39)

1. Thrombosis and inflammation as multicellular processes: Pathophysiologic significance of transcellular metabolism
2. Purines and neutrophil leukocytes
3. Adenosine, an endogenous anti-inflammatory agent
4. Adenosine: A physiological modulator of superoxide anion generation by human neutrophils
5. Release of oxygen metabolites from chemoattractant-stimulated neutrophils is inhibited by resting platelets: Role of extracellular adenosine and actin polymerization
6. Effects of adenosine on the functions of circulating polymorphonuclear leukocytes during hyperdynamic endotoxemia
7. Adenosine: An endogenous inhibitor of neutrophil-mediated injury to endothelial cells
8. Fructose-1,6-diphosphate or adenosine attenuate leukocyte adherence in postischemic skeletal muscle
9. Differential regulatory effects of adenosine on cytokine release by activated human monocytes
10. Multiple effects of dipyridamole on neutrophils and mononuclear leukocytes: Adenosine-dependent and adenosine-independent mechanisms
11. Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: Evidence that both effects are coupled to adenylate cyclase
12. Adenosine endogenously released during early reperfusion mitigates postischemic myocardial dysfunction by inhibiting platelet adhesion
13. Evidence for an anti-aggregatory effect of adenosine at physiological concentrations and for its role in the action of dipyridamole
14. Anti-aggregatory effects of physiological concentrations of adenosine in human whole blood as assessed by filtragometry
15. Effects of adenosine infusion with or without leukocyte depletion on recovery after hypothermic ischemia in neonatal lamb hearts
16. Adenosine spares platelets during cardiopulmonary bypass in man without causing systemic vasodilatation
17. Adenosine reduces postbypass transfusion requirements in humans after heart surgery
18. P-selectin binds to bacterial lipopolysaccharide
19. L-selectin: A novel receptor for lipopolysaccharide and its potential role in bacterial sepsis
20. The microcirculation during endotoxemia
21. Biochemistry and cell biology of bacterial endotoxins
22. Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain
23. Effects of endotoxemia on thrombopoiesis in man
24. Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia
25. Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of alpha-granules or lysosomes from, human platelets
26. Efficient flow cytometric assay for platelet-leukocyte aggregates in whole blood using fluorescence signal triggering
27. Correlated measurement of platelet release and aggregation in whole blood
28. Role of neutrophils in the deposition of platelets during acute inflammation
29. Platelet accumulation induced by bacterial endotoxin in rats
30. In vivo tracking of platelets: Circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function
31. Hypothesis: Is soluble P-selectin a new marker of platelet activation?
32. Von Willebrand factor: A marker of endothelial damage?
33. Platelet-mediated lymphocyte delivery to high endothelial venules
34. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18
35. Expression of P-selectin on hepatic endothelia and platelets promoting neutrophil removal by liver macrophages
36. Evidence for prothrombotic effect of exercise and limited protection by aspirin
37. Effect of adenosine on the expression of b2 integrins and L-selectin of human polymorphonuclear leukocytes in vitro
38. Effects of adenosine derivatives on human and rabbit platelet aggregation. Correlation of adenosine receptor affinities and antiaggregatory activity
39. Inhibition of platelet aggregation by adenosine receptor agonists