Selective corticotropin-releasing factor type 1 receptor antagonist blocks conditioned fear-induced release of noradrenaline in the hypothalamic paraventricular nucleus of rats

Journal of Neuroendocrinology

Volumn 12, Issue 10, 2000, Pages 1022-1026

  Otagiri, A ^a   Wakabayashi, I ^a   Shibasaki, Tamotsu ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Conditioned fear; Corticotropin releasing factor receptor antagonist; Microdialysis; Noradrenaline; Paraventricular nucleus

Indexed keywords

4 [4 (3 FLUOROPHENYL) 1,2,3,6 TETRAHYDRO 1 PYRIDINYL] 2 [N ETHYL N (4 ISOPROPYL 2 METHYLTHIOPHENYL)AMINO] 6 METHYLPYRIMIDINE; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR; DRUG VEHICLE; NORADRENALIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; BRAIN FUNCTION; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; DRUG ACTIVITY; ELECTRIC SHOCK; FEAR; HYPOTHALAMUS; MALE; MICRODIALYSIS; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; THALAMUS MIDLINE NUCLEUS;

ANIMALS; CONDITIONING (PSYCHOLOGY); ELECTROSHOCK; FEAR; HINDLIMB; MALE; MICRODIALYSIS; NOREPINEPHRINE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PYRIDINES; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE;

EID: 0033830143     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2000.00563.x     Document Type: Article

References (47)

1. Characterization of hippocampal norepinephrine release as measured by microdialysis perfusion: Pharmacological and behavioral studies
2. Role of noradrenergic projections to the bed nucleus of the stria terminalis in neuroendocrine and behavioral responses to fear-related stimuli in rats
3. Sensitization of norepinephrine release in medial prefrontal cortex: Effect of different chronic stress protocols
4. Paraventricular nucleus: A site for the integration of neuroendocrine and autonomic mechanisms
5. Role of paraventricular and supraoptic nuclei in central cardiovascular regulation in the rat
6. A comparison of the hemodynamic effects produced by electrical stimulation of subnuclei of the paraventricular nucleus
7. Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat
8. Injection of antineuropeptide Y γ-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats
9. Organization of some brain stem afferents to the paraventricular nucleus of the hypothalamus in the rat
10. Relationship of alpha-1- and alpha-2-adrenergic-binding sites to regions of the paraventricular nucleus of the hypothalamus containing corticotropin-releasing factor and vasopressin neurons
11. Noradrenergic activation in the paraventricular nucleus during acute and chronic immobilization stress in rats: An in vivo microdialysis study
12. Stress-induced norepinephrine release in the paraventricular nucleus of rats with brainstem hemisections: A microdialysis study
13. The response pattern of noradrenaline release to repeated stress in the hypothalamic paraventricular nucleus differs according to the form of stress in rats
14. Intracerebroventricular administration of neuropeptide Y inhibits release of noradrenaline in the hypothalamic paraventricular nucleus caused by manual restraint in the rat through an opioid system
15. Direct evidence of conditioned fear-elicited enhancement of noradrenaline release in the rat hypothalamus assessed by intracranial microdialysis
16. The role of ascending neuronal pathways in stress-induced release of noradrenaline in the hypothalamic paraventricular nucleus of rats
17. Involvement of the brain noradrenaline system in emotional changes caused by stress in rats
18. Characterization of corticotropin-releasing factor receptor subtypes Ann Ann NY Acad Sci
19. CRF 2α and CRF 2β receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues
20. Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary
21. Alcohol increases the expression of type 1, but not type 2α corticotropin-releasing factor (CRF) receptor messenger ribonucleic acid in the rat hypothalamus
22. Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain
23. 1 receptor antagonists, CRA 1000 and CRA 1001
24. Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001
25. Non-peptide corticotropin-releasing hormone receptor type 1 antagonist reverses restraint stress-induced shortening of sodium pentobarbital-induced sleeping time of rats: Evidence that an increase in mediated through CRH receptor type 1
26. Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats
27. Activation of noradrenergic locus coeruleus neurons by hemodynamic stress is due to local release of corticotropin-releasing factor
28. A CRF antagonist attenuates stress-induced increases in NA turnover in extended brain regions in rats
29. Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus
30. Biochemical mapping of noradrenergic nerves arising from the rat locus coeruleus
31. Regional topography within noradrenergic locus coeruleus as revealed by retrograde transport of horseradish peroxidase
32. Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning
33. Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release: Effects of novelty, habituation, and fear
34. Neurophysin pathways in the normal and hypophysectomized rat
35. Direct projections from the central amygdaloid nucleus to the hypothalamic paraventricular nucleus: Possible role in stress-induced adrenocorticotropin release
36. Contribution of the ventral subiculum to inhibitory regulation of the hypothalamo-pituitary-adrenocortical axis
37. Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis
38. Corticotropin-releasing factor innervation of the locus coeruleus region: Distribution of fibers and sources of input
39. Activation of locus coeruleus from nucleus paragigantocellularis: A new excitatory amino acid pathway in brain
40. Integration in the ventral medulla and coordination of sympathetic, pain and arousal functions
41. The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique
42. Response of locus coeruleus neurons to footshock stimulation is mediated by neurons in the rostral ventral medulla
43. Corticotropin-releasing factor-containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus cocruleus in the rat brain
44. CRFergic innervation of the paraventricular nucleus of the rat hypothalamus: A tract-tracing study
45. Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF
46. 2, receptors mediate anxiogenic-like behavior