The role of ascending neuronal pathways in stress-induced release of noradrenaline in the hypothalamic paraventricular nucleus of rats

Journal of Neuroendocrinology

Volumn 11, Issue 7, 1999, Pages 529-539

  Palkovits, M ^a,b,e   Baffi, J S ^a   Pacak, K ^c,d  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^e NIHM   (United States)

Author keywords

Brainstem hemisections; Fos expression; Microdialysis; Noradrenaline; Paraventricular nucleus; Stress

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; FORMALDEHYDE; NORADRENALIN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; EXTRACELLULAR FLUID; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LOCUS CERULEUS; LUMBAR SPINAL CORD; MALE; MEDULLA OBLONGATA; MICRODIALYSIS; NERVE CONDUCTION; NERVE ENDING; NONHUMAN; NORADRENALIN RELEASE; PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SPINAL CORD DORSAL HORN; SPINAL CORD TRANSSECTION; STRESS; THALAMUS MIDLINE NUCLEUS; THALAMUS NUCLEUS;

ANIMALS; BRAIN STEM; MALE; MICRODIALYSIS; NEURONS; NOREPINEPHRINE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; STRESS;

EID: 0033027148     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1999.00365.x     Document Type: Article

References (49)

1. Burstein R, Cliffer KD, Giesler GJ Jr Direct somatosensory projections from the spinal cord to the hypothalamus and telencephalon. J Neurosci 1987; 7: 4159-4164.
2. Cliffer KD, Burstein R, Giesler GJ Jr Distributions of spinothalamic, spinohypothalamic, and spinotelencephalic fibers revealed by anterograde transport of PHA-L in rats. J Neuroscience 1991; 11: 852-868.
3. Menétrey D, Roudier F, Besson J-M. Spinal neurons reaching the lateral reticular nucleus as studied in the rat by retrograde transport of horseradish peroxidase. J Comp Neurol 1983; 220: 439-452.
4. Kevetter GA, Willis WD. Collaterals of spinothalamic cells in the rat. J Comp Neurol 1983; 215: 453-464.
5. Menétrey D, Basbaum AI. Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation. J Comp Neurol 1987; 255: 439-450.
6. Lima D, Coimbra A. Neurons in the substantia gelatinosa rolandi (lamina II.) project to the caudal ventrolateral reticular formation of the medulla oblongata in the rat. Neurosci Lett 1991; 132: 16-18.
7. Lima D, Mendes-Ribeiro JA, Coimbra A. The spino-latero-reticular system of the rat: projections from the superficial dorsal horn and structural characterization of marginal neurons involved. Neuroscience 1991; 45: 137-152.
8. Tavares I, Lima D, Coimbra A. Neurons in the superficial dorsal horn of the rat spinal cord projecting to the medullary ventrolateral reticular formation express c-fos after noxious stimulation of the skin. Brain Res 1993; 623: 278-286.
9. Alonso G, Szafarczyk A, Balmefrezol M, Assenmacher I. Immunocytochemical evidence for stimulatory control by the ventral noradrenergic bundle of parvocellular neurons of paraventricular nucleus secreting corticotropin-releasing hormone and vasopressin in rats. Brain Res 1986; 397: 297-307.
10. Sawchenko PE. Effects of catecholamine-depleting medullary knife cuts on corticotropin-releasing factor and vasopressin immunoreactivity in the hypothalamus of normal and steroid manipulated rats. Neuroendocrinology 1988; 48: 459-470.
11. Gaillet S, Alonso G, Le Borgne R, Barbanel G, Malaval F, Assenmacher I, Szafarczyk A. Effects of discrete lesions in the ventral noradrenergic ascending bundle on the corticotropic stress response depend on the site of the lesion and on the plasma levels of adrenal steroids. Neuroendocrinology 1993; 58: 408-419.
12. Sawchenko PE, Swanson LW. The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat. Brain Res Rev 1982; 4: 275-325.
13. Cunningham ET Jr, Sawchenko PE. Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol 1990; 274: 60-76.
14. Palkovits M, Záborszky L, Feminger A, Mezey E, Fekete MIK, Herman JP, Kanyicska B, Szabó D. Noradrenergic innervation of the rat hypothalamus: Experimental biochemical and electron microscopic studies. Brain Res 1980; 191: 161-171.
15. Pacak K, Palkovits M, Kopin IJ, Goldstein DS. Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympatho-adrenal activity: In vivo microdialysis studies. Front Neuroendocrinol 1995; 16: 89-150.
16. Pacak K, Palkovits M, Kvetnansky R, Kopin IJ, Goldstein DS. Stress-induced norepinephrine release in the paraventricular nucleus of rats with brainstem hemisections: a microdialysis study. Neuroendocrinology 1993; 58: 196-201.
17. Mezey E, Palkovits M. CRF-containing neurons in the hypothalamic paraventricular nucleus: regulation, especially by catecholamines. Front Neuroendocrinol 1991; 12: 23-37.
18. Kaneko M, Hiroshige T. Site of the fast, rate-sensitive feedback inhibition of adrenocorticotropin secretion during stress. Am J Physiol 1978; 234: R46-R51.
19. Palkovits M, Mezey É, Skirboll LR, Hökfelt T. Adrenergic projections from the lower brainstem to the hypothalamic paraventricular nucleus, the lateral hypothalamic area and the central nucleus of the amygdala in rats. J Chem Neuroanat 1992; 5: 407-415.
20. Harbuz MS, Chowdrey HS, Jessop DS, Biswas S, Lightman SL. Role of catecholamines in mediating messenger RNA and hormonal responses to stress. Brain Res 1991; 551: 52-57.
21. Swanson LW, Simmons DM. Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: a hybridization histochemical study in the rat. J Comp Neurol 1989; 285: 413-435.
22. Li H-Y, Ericsson A, Sawchenko PE. Distinct mechanisms underlie activation of hypothalamic neurosecretory neurons and their medullary catecholaminergic afferents in categorically different stress paradigms. Proc Natl Acad Sci USA 1996; 93: 2359-2364.
23. Pacak K, Palkovits M, Makino S, Kvetnansky R, Kopin IJ, Goldstein DS. Brainstem hemisection decreases corticotropin-releasing hormone mRNA in the paraventricular nucleus but not in the central amygdaloid nucleus. J Neuroendocrinol 1996; 8: 543-551.
24. Kiss A, Palkovits M, Aguilera G. Neural regulation of corticotropin releasing hormone (CRH) and CRH receptor mRNA in the hypothalamic paraventricular nucleus in the rat. J Neuroendocrinol 1996; 8: 103-112.
25. Palkovits M. Afferents onto neuroendocrine cells. In: Ganten D, Pfaff D, eds. Current Topics in Neuroendocrinology, Vol 7. Berlin-Heildelberg, New York: Springer, 1986: 197-222.
26. Sawchenko PE, Arias C, Bittencourt JC. Inhibin β, somatostatin, and enkephalin immunoreactivities coexist in caudal medullary neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 1990; 291: 269-280.
27. Riche D, DePommery J, Menétrey D. Neuropeptides and catecholamines in efferent projections of the nuclei of the solitary tract in the rat. J Comp Neurol 1990; 293: 399-424.
28. Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 1977; 4: 161-174.
29. Abbott FV, Franklin KBJ, Westbrook RF. The formalin test: scoring properties of the first and second phases on the pain response in rats. Pain 1995; 60:91-102.
30. Makara GB, Stark E, Mihály K. Corticotrophin release induced by injection of formalin in rats with hemisection of the spinal cord. Acta Physiol Acad Sci Hung 1969; 35: 331-333.
31. Stark E, Makara GB, Palkovits M, Mihály K. Afferent pathways of stressful stimuli: their dependence on strength and the time elapsed after the onset of stimulation. Acta Physiol Acad Sci Hung 1970; 38: 43-49.
32. Eisenhofer G, Goldstein DS, Stull R, Keiser HR, Sunderland T, Murphy DL, Kopin IJ. Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase. Clin Chem 1986; 32: 2030-2033.
33. Pacak K, Armando K, Fukuhara K, Kvetnansky R, Palkovits M, Kopin IJ, Goldstein DS. Noradrenergic activation in the paraventricular nucleus during acute and chronic immobilization stress in rats: an in vivo microdialysis study. Brain Res 1992; 589: 91-96.
34. Bullitt E. Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J Comp Neurol 1990; 296: 517-530.
35. Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Ann Rev Neurosci 1991; 14: 421-451.
36. Presley RW, Menétrey D, Levine JD, Basbaum AI. Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci 1990; 10: 323-335.
37. Abbadie C, Lombard M-C, Morain F, Besson J-M. Fos-like immunoreactivity in the rat superficial dorsal horn induced by formalin injection in the forepaw: effects of dorsal rhizotomies. Brain Res 1992; 578: 17 25.
38. Senba E, Matsunaga K, Tohyama M, Noguchi K. Stress-induced c-fos expression in the rat brain: activation mechanism of sympathetic pathway. Brain Res Bull 1993; 31: 329-344.
39. Palkovits M, Baffi JS, Dvori S. Neuronal organization of stress response: pain-induced c-fos expression in brain stem catecholaminergic cell groups. Ann NY Acad Sci 1995; 771: 313-326.
40. Baffi JS, Pacak K, Szabo B, Palkovits M. Different stressors have different effects on c-fos activity of catecholaminergic neurons. In: McCarty R. Aguilera G, Sabban E, Kvetnansky R, eds. Stress: Molecular Genetic and Neurobiological Advances, Vol 2. New York: Gordon and Breach, 1996: 143-155.
41. Menétrey D, Gannon A, Levine JD, Basbaum Al. Expression of c-fos protein in interneurons and projecting neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol 1989; 285: 177-195.
42. Kobayashi RM, Palkovits M, Kopin IJ, Jacobowitz DM. Biochemical mapping of noradrenergic nerves arising from the rat locus coeruleus. Brain Res 1974; 77: 269-279.
43. Záborszky L, Brownstein MJ, Palkovits M. Ascending projections to the hypothalamus and limbic nuclei from the dorsolateral pontine tegmentum: a biochemical and electron microscopic study. Acta Morph Acad Sci Hung 1977; 25: 175-188.
44. Foote SL, Aston-Jones G, Bloom FE. The nucleus locus coeruleus: new evidence of anatomical and physiological specificity. Physiol Rev 1983; 63: 844-914.
45. Szafarczyk A, Guillaume V, Conte-Devoix B, Alonso G, Malaval F, Pares-Herbute N, Oliver C, Assenmacher I. Central catecholaminergic system stimulates secretion of CRH at different sites. Am J Physiol 1988; 255: E463-E468.
46. Chuluyan HE, Saphier D, Rohn WM, Dunn AJ. Noradrenergic innervation of the hypothalamus participates in adrenocortical responses to interleukin-1. Neuroendocrinology 1992; 56: 106-111.
47. Weiss ML, Hatten GI. Collateral input to the paraventricular and supraoptic nuclei in rat. II. Afferents from the ventral lateral medulla and nucleus tractus solitarius. Brain Res Bull 1990; 25: 561-567.
48. Palkovits M, Dvori S, Pacak K, Baffi JS. Stress-induced functional activity in neuronal cells of catecholaminergic, hypothalamic and amygdaloid nuclei. In: McCarty R, Aguilera G, Sabban E, Kvetnansky R, eds. Stress: Molecular Genetic and Neurobiological Advances. Vol 1. New York: Gordon and Breach, 1996: 23-47.
49. Silverman AJ, Hoffman DL, Zimmerman EA. The descending afferent connections of the paraventricular nucleus of the hypothalamus (PVN). Brain Res Bull 1981; 6: 47-61.