NT-4/5 exacerbates free radical-induced neuronal necrosis in vitro and in vivo

Neurobiology of Disease

Volumn 7, Issue 4, 2000, Pages 251-259

  Won, Seok J ^a   Park, Eun C ^a   Ryu, Bo R ^a   Ko, Hyuk W ^a   Sohn, Seonghyang ^a   Kwon, Hyuk J ^a   Gwag, Byoung J ^a  

^a Ajou University   (South Korea)

Author keywords

Free radical; Necrosis; NT 4 5; Oxidative stress; Striatal cell culture; Striatum

Indexed keywords

FREE RADICAL;

ARTICLE; HUMAN; KOREA; MEDICAL RESEARCH; NECROSIS; NERVE CELL DEGENERATION; PRIORITY JOURNAL;

EID: 0033830063     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0284     Document Type: Article

References (59)

1. Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12 cells
2. Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo
3. Neurotrophins: A family of proteins supporting the survival of neurons
4. Brain-derived growth factor protects against ischemic cell damage in rat hippocampus
5. Brain-derived neurotrophic factor and nerve growth factor potentiate excitatory synaptic transmission in the rat visual cortex
6. Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury
7. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults
8. Distinct Neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats
9. Neurotrophin-4/5 (NT-4/5) increases adult rat retinal ganglion cell survival and neurite outgrowth in vitro
10. Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures
11. The role of neurotrophins in the developing nervous system
12. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
13. Increased nigral iron content in postmortem parkinsonian brain
14. Internucleosomal cleavage of DNA as the sole criterion for apoptosis may be artifactual
15. Basic fibroblast growth factor protects cerebellar neurons in primary culture from NMDA and non-NMDA receptor mediated neurotoxicity
16. BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons
17. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat
18. Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions
19. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study
20. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
21. PKC-dependent modulation of neuronal apoptosis and oxidative stress by BDNF
22. BDNF or IGF-1 potentiates free radical-mediated injury in cortical cell cultures
23. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
24. Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: Regulation by NGF
25. The reaction of NO with superoxide
26. Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance
27. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
28. Role of neurotrophins in mouse neuronal development
29. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo
30. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
31. Potentiated necrosis of cultured cortical neurons by neurotrophins
32. Glutamate triggers internucleosomal DNA cleavage in neuronal cells
33. The nerve growth factor 35 years later
34. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors
35. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells
36. Oxidative stress hypothesis in Alzheimer's disease
37. Growth factors protect neurons against excitotoxic/ischemic damage by stabilizing calcium homeostasis
38. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo
39. Nerve growth factor potentiates the oxidative necrosis of striatal cholinergic neurons
40. Oxidative stress is not required for neuronal apoptosis in cortical cell cultures
41. BDNF potentiates spontaneous Ca2+ oscillations in cultured hippocampal neurons
42. Differential susceptibility to neurotoxicity mediated by neurotrophins and neuronal nitric oxide synthase
43. Growth factors and vitamin E modify neuronal glutamate toxicity
44. Amelioration of delayed neuronal death in the hippocampus by nerve growth factor
45. Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons
46. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
47. Kainate induces apoptosis in neurons
48. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
49. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
50. Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
51. Glutamate neurotoxicity in mouse cortical neurons: Atypical necrosis with DNA ladders and chromatin condensation
52. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: Involvement of the glutathione system
53. A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture
54. Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex
55. The role of iron-induced hippocampal peroxidation in acute epileptogenesis
56. Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death
57. Neurotrophins induced NMDA receptor expression in cultured rat cortical neurons
58. The possible role of iron in the etiopathology of Parkinson's disease
59. Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration