Adoptive transfer: The role of perforin in mouse cytotoxic T lymphocyte rejection of human tumor xenografts in vivo

Xenotransplantation

Volumn 5, Issue 2, 1998, Pages 146-153

  Smyth, Mark J ^a   Kershaw, Michael H ^a   Darcy, Phillip K ^a   Trapani, Joseph A ^a  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

Author keywords

Cytotoxicity; Fas ligand; Human; Mouse; Perforin; Xenotransplantation

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; FAS LIGAND; PERFORIN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; XENOTRANSPLANTATION;

EID: 0031979471     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.1998.tb00020.x     Document Type: Article

References (32)

1. AUCHINCLOSS H JR. Why is cell-mediated xenograft rejection so strong? Xenotransplantation 1995; 3:19.
2. SEEBACH JD, YAMADA K, MCMORROW IM, SACHS DH, DERSIMONIAN HD. Xenogeneic human anti-pig cytotoxicity mediated by activated natural killer cells. Xenotransplantation 1996; 3:188.
3. + or B lymphocytes, can reject xenogeneic skin grafts. Xenotransplantation 1994; 1:8.
4. + T cell-depleted diabetic mice. Transplantation 1990; 50:657.
5. PODACK ER, HENGARTNER H, LICHTENHELD MG. A central role for perforin in cytolysis? Annu Rev Immunol 1991; 9:129.
6. HENKART PA. Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules. Immunity 1994; 1:343.
7. LIU C-C, WALSH CM, YOUNG JD-E. Perforin : structure and function. Immunol Today 1995; 16:194.
8. WALSH CM, MATLOUBIAN M, LIU C-C, UEDA R, KURAHARA CG, CHRISTENSEN JL, HUANG MTF, YOUNG JD-E, AHMED R, CLARK WR. Immune function in mice lacking the perforin gene. Proc Natl Acad Sci USA 1994; 91:10854.
9. KAGI D, VIGNAUX F, LEDERMANN B, BURKI K, DEPRAETERE V, NAGATA S, HENGARTNER H, GOLSTEIN P. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994; 265:528.
10. 2+-independent T cell- mediated cytotoxicity. J Exp Med 1993; 177:195.
11. ZHENG L, FISHER G, MILLER RE, PESCHON J, LYNCH DH, LENARDO MJ. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 1995; 377:348.
12. BISHOP DK, CHAN S, LI W, ENSLEY RD, XU S, EICHWALD EJ. CD4-positive helper T lymphocytes mediate mouse cardiac allograft rejection independent of donor alloantigen specific cytotoxic T lymphocytes. Transplantation 1993; 56:892.
13. SCHULZ M, SCHUURMAN H-J, JOERGENSEN J, STEINER C, MEERLOO T, KAGI D, HENGARTNER H, ZINKERNAGEL RM, SCHREIER MH, BURKI K, LEDERMANN B. Acute rejection of vascular heart allografts by perforin-deficient mice. Eur J Immunol 1995; 25:474.
14. WALSH CM, HAYASHI F, SAFFRAN DC, JU S-T, BERKE G, CLARK WR. Cell-mediated cytotoxicity results from, but may not be critical for, primary allograft rejection. J Immunol 1995; 156:1436.
15. LARSEN CP, ALEXANDER DZ, HENDRIX R, RITCHIE SC, PEARSON TC. Fas-mediated cytotoxicity: An immunoeffector or immunoregulatory pathway in T cell-mediated immune responses? Transplantation 1995; 60:221.
16. SMYTH MJ, SUTTON VR, KERSHAW MH, TRAPANI JA. Xenospecific cytotoxic T lymphocytes use perform- and Fas-mediated lytic pathways. Transplantation 1996; 62:1529.
17. SEMPLE TU, QUINN LA, WOODS LF, MOORE GE. Tumor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxicity model. Cancer Res 1978; 38:1345-1355.
18. CONZELMANN A, CORTHESY P, CIANFRIGLIA M, SILVA A, NABHOLZ M. Hybrids between rat lymphoma and mouse T cells with inducible cytolytic activity. Nature 1982; 298:170-172.
19. WONG GHW, GOEDDEL, DV. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J Immunol 1994; 152:1751.
20. SMYTH MJ, KERSHAW MH, TRAPANI JA. Xenospecific cytotoxic T lymphocytes: potent lysis in vitro and in vivo. Transplantation 1997; 63:1171.
21. AUCHINCLOSS H. Xenogeneic transplantation: A review. Transplantation 1988; 46:1.
22. ENGELHARD VH, BENJAMIN C. Xenogeneic cytotoxic T-cell clones recognize alloantigenic determinants on HLA-A2. Immunogenetics 1983; 18:461.
23. ZENGERLE U, HOFFMANN-FEZER G, SCHUH R, THIERFELDER S. Suppression of normal and neoplastic human T cells with unconjugated monoclonal antibodies in SCID mouse chimeras. Bone Marrow Transplant 1995; 16:337.
24. MURRAY AG, PETZELBAUER P, HUGHES CC, COSTA J, ASKENASE P, POBER JS. Human T- cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse. Proc Natl Acad Sci USA 1994; 91:9146.
25. LEGROS-MAIDA S, SOULIE A, BENVENUTI C, WARGNIER A, VALLEE N, BERTHOU C, GUILLET J, SASPORTES M, SIGAUX N. Granzyme B and perforin can be used as predictive markers of acute rejection in heart transplantation. Eur J Immunol 1994; 24:229-233.
26. CLEMENT MV, LEGROS-MAIDA S, ISRAEL-BIET D, CARNOT F, SOULIE A, REYNAUD P, GUILLET J, GANDJBAKCH I, SASPORTES M. Perforin and granzyme B expression is associated with severe acute rejection: Evidence for in situ localization in alveolar lymphocytes of lung-transplanted patients. Transplantation 1994; 57:322.
27. MCDIARMID SV, FARMER DG, KUNIYOSHI JS, ROBERT M, KHADAVI A, SHARED A, BUSUTTIL RW. Perforin and granzyme B. Cytolytic proteins up-regulated during rejection of rat small intestine allografts. Transplantation 1995; 59:762.
28. NAKAJIMA F, KHANNA A, XU G, LAGMAN M, HASCHEMEYER R, MOURADIAN J, WANG JC, STENZEL KH, RUBIN AL, SUTHANTHIRAN M. Immunotherapy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: Stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression. Proc Natl Acad Sci USA 1994;91:7889.
29. BRAUN MY, LOWIN B, FRENCH L, ACHA-ORBEA H, TSCHOPP J. Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease. J Exp Med 1996; 183:657.
30. VAN-DEN-BROEK MF, KAGI D, ZINKERNAGEL RM, HENGARTNER H. Perforin dependence of natural killer cell-mediated tumor control in vivo. Eur J Immunol 1995; 25:3514.
31. VAN DEN BROEK MF, KAGI D, OSSENDORP F, TOES R, VAMVAKAS S, LUTZ WK, MELIEF CJM, ZINKERNAGEL RM, HENGARTNER H. Decreased tumor surveillance in perforin-deficient mice. J Exp Med 1996; 184:1781.
32. DURANDY A, LEDEIST F, EMILE JF, DEBATIN K, FISCHER A (1997). Sensitivity of Epstein- Barr virus-induced B cell tumor to apoptosis mediated by anti-CD95/Apo-1/fas antibody. Eur J Immunol 1997; 27:538.