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Volumn 122, Issue 35, 2000, Pages 8403-8412

Calicheamicin-DNA recognition: An analysis of seven different drug-DNA complexes

Author keywords

[No Author keywords available]

Indexed keywords

CALICHEAMICIN; DNA; PYRIMIDINE NUCLEOSIDE;

EID: 0033824779     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0005183     Document Type: Article
Times cited : (15)

References (44)
  • 18
    • 0342564875 scopus 로고    scopus 로고
    • The ACCT complex has been reported by us previously (see ref 13).
    • The ACCT complex has been reported by us previously (see ref 13).
  • 19
    • 0343434816 scopus 로고    scopus 로고
    • note
    • We have found that calicheamicin effects double-stranded cleavage of all the specific complexes. This exchange process is therefore not a general feature of calicheamicin binding and activity.
  • 25
    • 0342999289 scopus 로고    scopus 로고
    • Pal, S. Ph.D. Thesis, Princeton University
    • Pal, S. Ph.D. Thesis, Princeton University, 1997.
    • (1997)
  • 29
    • 0343434813 scopus 로고    scopus 로고
    • note
    • 3 and experimental results.
  • 31
    • 0342999288 scopus 로고    scopus 로고
    • note
    • Calicheamicin does not cleave mixed DNA sequences, as observed in numerous gel-electrophoresis experiments. We observed no binding of the native oligosaccharide to mixed sequences using capillary electrophoresis (see ref 17).
  • 32
    • 0343870563 scopus 로고    scopus 로고
    • note
    • This complex was previously analyzed by Paloma et al. (ref 14) Because the exchange process made it impossible to assign the spectra at room temperature, these authors made their assignments at 45°C, a temperature at which conformational averaging simplified the spectra.
  • 33
    • 0343434814 scopus 로고    scopus 로고
    • note
    • 36 also suggest that calicheamicin recognizes common conformational features first, and only secondarily discriminates between pyrimidine sequences based on specific contacts.
  • 42
    • 0026758712 scopus 로고
    • Springer-Verlag: New York
    • Distances for the hydrogen bonding restraints were based on crystal structure analysis, see: Saenger, W. Principles of Nucleic Acis Structure; Springer-Verlag: New York, 1984; p 123. In addition, loose backbone torsion angle restraints were included because the NMR data indicate that the DNA maintains a right-handed conformation, see: Schmitz, U.; Sethson, I.; Egan W. M.; James, T. L. J. Mol. Biol. 1992, 227, 510-531.
    • (1984) Principles of Nucleic Acis Structure , pp. 123
    • Saenger, W.1
  • 43
    • 0026758712 scopus 로고
    • Distances for the hydrogen bonding restraints were based on crystal structure analysis, see: Saenger, W. Principles of Nucleic Acis Structure; Springer-Verlag: New York, 1984; p 123. In addition, loose backbone torsion angle restraints were included because the NMR data indicate that the DNA maintains a right-handed conformation, see: Schmitz, U.; Sethson, I.; Egan W. M.; James, T. L. J. Mol. Biol. 1992, 227, 510-531.
    • (1992) J. Mol. Biol. , vol.227 , pp. 510-531
    • Schmitz, U.1    Sethson, I.2    Egan, W.M.3    James, T.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.