Differentiation of multicentric origin from intra-organ metastatic spread of hepatocellular carcinomas by comparative genomic hybridization

Journal of Pathology

Volumn 192, Issue 1, 2000, Pages 43-51

  Wilkens, Ludwig ^a   Bredt, Martin ^a   Flemming, Peer ^a   Klempnauer, Juergen ^a   Kreipe, Hans Heinrich ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Comparative genomic hybridization metastasis; Hepatocellular carcinoma

Indexed keywords

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GENETICS; CASE REPORT; CHROMOSOME ABERRATION; COMPARATIVE GENOMIC HYBRIDIZATION; DIFFERENTIAL DIAGNOSIS; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; LIVER CELL CARCINOMA; MALE; METASTASIS; PRIORITY JOURNAL; TUMOR GROWTH;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CHROMOSOME ABERRATIONS; DIAGNOSIS, DIFFERENTIAL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER NEOPLASMS; MALE; NUCLEIC ACID HYBRIDIZATION; TUMOR STEM CELLS;

EID: 0033824265     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH671>3.0.CO;2-Z     Document Type: Article

References (41)

1. Hepatocellular carcinoma in the world: Epidemiologic questions
2. Primary hepatic carcinomas
3. Potentially multicentric hepatocellular carcinoma: Clinicopathologic characteristics and postoperative prognosis
4. Results of surgical treatment for recurrent hepatocellular carcinoma; Comparison of outcome among patients with multicentric carcinogenesis, intrahepatic metastasis, and extrahepatic recurrence
5. Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma
6. Multicentric independent development of hepato-cellular carcinoma revealed by analysis of hepatitis B virus integration pattern
7. Clonal origin of hepatoma detected by integration of hepatitis B virus D.N.A.
8. Clonal origin of hepatitis B virus-associated hepatocellular carcinoma
9. Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from Britain
10. Different pattern of chromosomal allele loss in multiple hepatocellular carcinomas as evidence of their multifocal origin
11. DNA-ploidy pattern in synchronous and metachronous hepatocellular carcinomas
12. Abnormalities of chromosome 1 and loss of heterozygosity on lp in primary hepatomas
13. Chromosome lp aberrations are frequent in human primary hepatocellular carcinoma
14. Cytogenetic findings in three primary hepatocellular carcinomas
15. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
16. Detection of complete and partial chromosome gains and losses by comparative genomic hybridization
17. Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: Their relationship to clinico pathological features
18. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis
19. Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization
20. Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization
21. Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas
22. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumours
23. DNA copy number amplifications in human neoplasms. Review of comparative genomic hybridisation
24. Demonstration of the Philadelphia translocation by fluorescence in situ hybridization (FISH) in paraffin sections and identification of aberrant cells by a combined FISH/immunophenotyping approach
25. Detection of numerical karyotype changes in the giant cells of Hodgkin's lymphomas by a combination of FISH and immunohistochemistry applied to paraffin sections
26. Rapid prenatal diagnosis of chromosomal aneuploidies by fluorescence in situ hybridization: Clinical experience with 4,500 specimens
27. Optimization of comparative genomic hybridization using fluorochrome conjugated to dCTP and dUTP nucleotides
28. Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer
29. Frequent genetic alterations at the distal region of chromosome lp in human hepatocellular carcinomas
30. Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: Association with elevated alpha-fetoprotein production
31. Chromosomal aberrations in hepatocellular carcinomas: Relationship with pathological features
32. Comprehensive allelotyping of human hepatocellular carcinoma
33. Allelotype analysis of hepatocellular carcinoma
34. Deletion mapping of chromosome 4q in hepatocellular carcinoma
35. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP
36. State of hepatitis B viral genomes in cirrhotic and hepatocellular carcinoma nodules
37. Multiple hepatocellular carcinomas at the early stage have different clonality
38. Genomic heterogeneity in synchronous hepatocellular carcinoma
39. Analysis of hematologic diseases using conventional karyotyping, fluorescence in situ hybridization (FISH), and comparative genomic hybridization (CGH)
40. Chromosomal analysis of renal angiomyolipoma by comparative genomic hybridization: Evidence for clonal origin