The expression pattern of the AML1 gene in non-Hodgkin's B-cell lymphomas and normal B lymphocytes

Blood Cells, Molecules, and Diseases

Volumn 26, Issue 3, 2000, Pages 186-192

  Chimienti, Guglielmina ^a   Alaibac, Mauro ^b,c   Marzullo, Franco ^c   Carbone, Antonio ^d   Pepe, Gabriella ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^d National Institute of Oncology   (Italy)

Author keywords

Alternative splicing; B lymphocytes; Lymphoid neoplasm; RT PCR; Transcription pattern

Indexed keywords

AML 1 PROTEIN; GENE PRODUCT; MESSENGER RNA; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CONTROLLED STUDY; DNA MODIFICATION; GENE CONTROL; GENE EXPRESSION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; RNA SPLICING;

EID: 0033822313     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2000.0295     Document Type: Article

References (21)

1. Leukemia/Drosophila homology
2. AML1, AML2, and AML3, the human members of the runt domain gene-family: CDNA, structure, expression, and chromosomal localization
3. The runt domain identifies a new family of heteromeric transcription regulators
4. Isolation of PEPB2αB cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1
5. PEPB2αB/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials
6. AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia
7. A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1
8. Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions
9. An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms
10. A novel transcript encoding an N-terminally truncated AML1/PEBP2αB protein interferes with trans-activation and blocks granulocytic differentiation of 32Dcl3 myeloid cells
11. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
12. AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia
13. Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia
14. High frequency of t(12;21) in childhood acute lymphoblastic leukemia detected by RT-PCR
15. Down syndrome and acute leukemia: Increased risk may be due to trisomy 21
16. Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and trans-activational potencies
17. Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms
18. Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia
19. The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability
20. BCL-2 gene expression in hematopoietic cell differentiation
21. Interleukin 3 is a growth factor for human follicular B cell lymphoma