Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis

Japanese Heart Journal

Volumn 41, Issue 4, 2000, Pages 507-517

  Inomata, Takayuki ^a   Watanabe, Takehiro ^b   Haga, Manabu ^b   Hirahara, Hiroyuki ^b   Abo, Toru ^b   Okura, Yuji ^b   Hanawa, Haruo ^b   Kodama, Makoto ^b   Izumi, Tohru ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Anergy; Antibody therapy; Autoimmune myocarditis; Cardiomyopathy; Cytokine; Myosin

Indexed keywords

CD2 ANTIGEN; CD3 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD 2; MYOSIN; MYOSIN ANTIBODY; RECOMBINANT INTERLEUKIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; CLONAL ANERGY; CONTROLLED STUDY; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOTHERAPY; LYMPH NODE CELL; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE SUBPOPULATION;

EID: 0033819215     PISSN: 00214868     EISSN: None     Source Type: Journal    
DOI: 10.1536/jhj.41.507     Document Type: Article

References (38)

1. Chronic relapsing pericarditis and dilated cardiomyopathy: Serological evidence of persistent enterovirus infection
2. The role of myocarditis and myocardial fibrosis in dilated cardiomyopathy
3. Myosin-induced acute myocarditis is a T cell-mediated disease
4. In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis
5. T lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex
6. Accessory cell signals involved in T-cell activation
7. The use of monoclonal antibodies to achieve immunological tolerance
8. Anti-αβT cell receptor antibody prevents the progression of experimental autoimmune myocarditis
9. Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent the progression of experimental autoimmune myocarditis
10. T-lymphocyte activation: The biology and function of CD2 and CD4
11. Anti-CD2 antibodies reduce T cell unresponsiveness in vivo
12. Long-term survival of cardiac allografts in rats treated before and after surgery with monoclonal antibody to CD2
13. Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat
14. Cardiac myosin from pig heart ventricle. Purification and enzymatic properties
15. Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages
16. T-lymphocyte heterogeneity in the rat: Separation of functional subpopulations using monoclonal antibody
17. Two subsets of rat T lymphocytes defined with monoclonal antibodies
18. Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody
19. Localization of porcine cardiac myosin epitopes that induce experimental autoimmune myocarditis
20. Regulation of autoimmune disease physiological and therapeutic
21. Effects of the anti-CD2 mAb OX34 on in vivo proliferation
22. Clonal expansion versus functional clonal activation: A costimulatory signaling detemines the outcome of T cell antigen receptor occupancy
23. Transactivation by AP-1 is a molecular target of T cell clonal anergy
24. Human TH1 and TH2 subsets: Doubt no more
25. + T cells in vivo. Differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts
26. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
27. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
28. Characterization of cytokine and iNOS mRNA expression in situ during the course of experimental autoimmune myocarditis in rats
29. + suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion
30. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
31. Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns
32. Coexistence of Th1 and Th2-type cytokine profiles in anti-CD2 monoclonal antibody-induced tolerance
33. Anti-CD2 mAb suppress cytotoxic lymphocyte activity by generation of Th2 suppressor cells and receptor blockade
34. Anti-CD2 monoclonal antibodies alter cell-mediated immunity in vivo
35. Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies
36. Use of monoclonal antibodies in vivo as a therapeutic strategy for alloimmune or autoimmune reactivity: The Basancon experience
37. How can myocarditis be diagnosed and should it be treated?
38. Treatment of myocarditis with OKT3 monoclonal antibody