Coexistence of Th1- and Th2-type cytokine profiles in anti-CD2 monoclonal antibody-induced tolerance

Transplantation

Volumn 62, Issue 9, 1996, Pages 1285-1292

  Krieger, Nancy R ^a   Most, Daniel ^b   Bromberg, Jonathan S ^c   Holm, Bari ^a   Huie, Philip ^b   Sibley, Richard K ^b   Dafoe, Donald C ^a   Alfrey, Edward J ^a,d  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; MONOCLONAL ANTIBODY;

ALLOGRAFT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HELPER CELL; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; IN SITU HYBRIDIZATION; MIXED LYMPHOCYTE CULTURE; MIXED LYMPHOCYTE REACTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD2; CYTOKINES; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; RATS; RATS, INBRED LEW; RATS, WISTAR; TH1 CELLS; TH2 CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0030447301     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199611150-00019     Document Type: Article

References (47)

1. Bromberg JS. Current research review. The biology of CD2: adhesion, transmembrane signal, and regulatory receptor of immunity. J Surg Res 1993; 54: 258.
2. Beyers AD, Barclay N, Law DA, Qi H, Williams AF. Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen. Immunol Rev 1989; 111: 59.
3. Moingeon P, Chang HC, Sayre PH, et al. The structural biology of CD2. Immunol Rev 1989; 111: 111.
4. Biere BE, Burakoff SJ. T-lymphocyte activation: the biology and function of CD2 and CD4. Immunol Rev 1989; 111: 267.
5. Yagita H, Nakamura T, Karasuyama H, Okumura K. Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc Natl Acad Sci USA 1989; 86: 645.
6. Yagita H, Nakamura T, Asakawa J, et al. CD2 expression in murine B cell lineage. Int Immunol 1989; 1: 94.
7. Altevogt P, Michaelis M, Kyewski B. Identical forms of the CD2 expressed by mouse T and B lymphocytes. Eur J Immunol 1989; 19: 1509.
8. Sen J, Rosenberg N, Burakoff SJ. Expression and ontogeny of CD2 on murine B cells. J Immunol 1990; 144: 2925.
9. Bromberg JS, Chavin KD, Altevogt P, et al. Anti-CD2 monoclonal antibodies alter cell-mediated immunity in vivo. Transplantation 1991; 51: 219.
10. Chavin KD, Qin L, Yon R, Lin J, Yagita H, Bromberg JS. Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade. J Immunol 1994; 152: 3729.
11. Chavin KD, Lau HT, Bromberg JS. Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies. Transplantation 1992; 54: 286.
12. Barlow AK, Like AA. Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat. Am J Pathol 1992; 141: 1043.
13. Hirahara H, Tsuchida M, Watanabe T, et al. Long-term survival of cardiac allografts in rats treated before and after surgery with monoclonal antibody to CD2. Transplantation 1995; 59: 85.
14. Ono K, Lindsey ES. Improved techniques of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225.
15. Alfrey EJ, Wang X, Lee L, et al. Tolerance induced by direct inoculation of donor antigen in the thymus in low and high responder rodents. Transplantation 1995; 59: 1171.
16. Altevogt P, Michaelis M, Kyewski B. Identical forms of the CD2 antigen expressed by mouse T and B lymphocytes. Eur J Immunol 1989; 19: 1509.
17. Hunig T, Wallny H, Hartley JK, Lawetzky A, Tiefenthaler G. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation: differential reactivity with subsets of immature and mature T lymphocytes. J Exp Med 1989; 169: 73.
18. Abraham RT, Ho SN, McKean DJ. Bioassay of interleukins. J Tissue Cult Methods 1987; 10: 93.
19. Alfrey EJ, Wang X, Lee L, et al. Interferon gamma (IFN-γ) and interleukin 10 (IL-10) mRNA are up-regulated after orthotopic liver transplantation in tolerant rats: evidence for cytokine mediated immune dysregulation. Surgery 1995; 118: 399.
20. McKnight AJ, Mason DW, Barclay AN. Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin 2 cDNA probe to rat MHC class II-associated invariant chain mRNA. Immunogenetics 1989; 30: 145.
21. McKnight AJ, Mason DW, Barclay AN. Sequence of a partial rat interleukin 4 cDNA clone obtained by the polymerase chain reaction. Unpublished as per GenBank.
22. Vieira P, de Waal-Malefyt R, Dang MN, et al. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Ebstein-Barr virus open reading frame BCRF1. Proc Natl Acad Sci USA 1991; 88: 1172.
23. Dijkema R, van der Meide PH, Dubbeld M, Caspers M, Wubben J, Schellekens H. Cloning, expression, and purification of rat interferon gamma. Methods Enzymol 1986; 199; 453.
24. Guckel B, Berek C, Lutz M, Altevogt P, Schirrmacher V, Kyewski BA. Anti-CD2 antibodies induce T cell unresponsiveness in vivo. J Exp Med 1991; 174: 957.
25. Roark JH, Posselt AM, Campos L, et al. Prolongation of rat pancreatic islet allograft survival by anti-CD2 monoclonal antibody treatment. Transplantation 1992; 54: 1098.
26. + T cells. Transplantation 1992; 54: 483.
27. Nakamura T, Takahashi K, Fukazawa T, et al. Relative contribution of CD2 and LFA-1 to murine T and natural killer cell functions. J Immunol 1990; 145: 3628.
28. Qin S, Wise M, Cobbold SP, Leong L, Kong Y-CM. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol 1994; 76: 241.
29. Mosmann TR, Cherwinski H, Bond MW, Gieldin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348.
30. Cherwinski HM, Schumacher JH, Brown KD, Mosmann TR. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 1987; 166: 1229.
31. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell clone. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170: 2081.
32. Paul WE, Seder RA. Lymphocyte responses and cytokines. Cell 1994; 76: 241.
33. + T cells. Annu Rev Immunol 1994; 12: 635.
34. Wu CJ, Lovett M, Wong-Lee J, et al. Cytokine gene expression in rejecting cardiac allografts. Transplantation 1992; 54: 326.
35. O'Connell PJ, Pacheco-Silva A, Nickerson PW, et al. Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts. J Immunol 1993; 53: 1281.
36. Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems: the differential activation of Th2-like effector cells in peripheral tolerance. Transplantation 1992; 53: 1281.
37. Dallman MJ, Larsen CP, Morris PJ. Cytokine gene transcription in vascularized organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med 1991; 174: 493.
38. Chen N, Field E. Enhanced type 2 and diminished type 1 cytokines in neonatal tolerance. Transplantation 1995; 59: 933.
39. Nickerson P, Steurer W, Steiger J, Zheng X, Steele AW, Strom TB. Cytokines and the Th1/Th2 paradigm in transplantation. Curr Opin Immunol 1994; 6: 757.
40. + T cells in vivo: differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts. J Immunol 1992; 148: 1308.
41. Hancock WW, Sayegh MH, Kwok CA, Weiner HL, Carpenter CB. Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 activation. Transplantation 1993; 55: 1112.
42. Dallman MJ, Shiho O, Page TH, Wood KJ, Morris PJ. Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med 1991; 173: 79.
43. Dallman MJ, Wood KJ, Hamano K, et al. Cytokines and peripheral tolerance to alloantigen. Immunol Rev 1993; 133: 1.
44. Sayegh MH, Akalin E, Hancock WW. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1969.
45. Mottram PL, Han WR, Purcell LJ, McKenzie IFC, Hancock WW. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-γ in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 1995; 59: 559.
46. Moore KW, O'Garra A, DeWaal-Malefyt R, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993; 11: 165.
47. Qin L, Chavin KD, Ding Y, et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model: immunosuppression with TGF-B1 or vIL-10. Transplantation 1995; 59: 809.