Effect of ion pairing with alkylamines on the in-vitro dermal penetration and local tissue disposition of salicylates

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 8, 2000, Pages 929-940

  Megwa, S A ^a   Cross, S E ^a   Whitehouse, M W ^a   Benson, H A E ^a   Roberts, M S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC AMINE; BUTYLAMINE; DECYLAMINE; DODECYLAMINE; ETHYLAMINE; HEPTYLAMINE; HEXYLAMINE; METHYLAMINE; NONYLAMINE; OCTYLAMINE; PENTYLAMINE; PROPYLAMINE; SALICYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNDECYLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL TRIAL; DRUG ACCUMULATION; DRUG DISPOSITION; DRUG EFFECT; DRUG PENETRATION; DRUG POTENTIATION; DRUG TISSUE LEVEL; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; ION PAIR EXTRACTION; LIPOPHILICITY; MALE; MEMBRANE TRANSPORT; MOLECULAR INTERACTION; NONHUMAN; RAT;

EID: 0033817774     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774813     Document Type: Article

References (36)

1. Coupled transport in membranes II. The mechanism of uranium transport with a tertiary amine
2. Chromatographic indicies determined on an immobilized artificial membrane (IAM) column as descriptors of lipophilic and polar interactions of 4-phenyldihydropyridine calcium-channel blockers with biomembranes
3. Facilitated percutaneous absorption: A model system
4. Effect of exercise and heat exposure on percutaneous absorption of methyl salicylate
5. Relevance of solubility parameter in ion association extraction systems
6. Mechanisms of liposomes/water partitioning of (p-methylbenzyl)alkylamines
7. Ion pairs and solubility behaviour
8. Facilitated transport of cationic drugs across a lipoidal membrane by oleic acid and lauric acid
9. In vitro and in vivo enhancement of skin permeation with oleic and lauric acids
10. Enhanced in vitro skin permeation of cationic drugs
11. Determination of amines and quaternary ammonium ions as complexes with picrate. Part 3. Relations between extraction constants and the nature of the cation and of the organic phase
12. Facilitated transport of sodium salicylate across an artificial lipid membrane by azone
13. Local necrosis and interstitial nephritis due to topical methyl salicylate and menthol
14. In vitro cutaneous disposition of a topical diclofenac lotion in human skin: Effect of a multidose regimen
15. Ion pair extraction of pharmaceutical amines
16. Extraction of octyl sulfate into 1-pentanol
17. Enhanced in vitro percutaneous penetration of salicylate by ion pair formation with alkylamines
18. Preparation of isolated sheets of human stratum corneum
19. In vitro/in vivo difference in enhanced skin permeation of nicardipine hydrochloride by the 1-methanol-ethanol system
20. Selective copper recovery with two types of liquid membrane
21. Relationship between lipophilicity and skin permeability of various drugs from an ethanol/water/lauric acid system
22. Percutaneous absorption of salicylates from some commercially available topical products containing methyl salicylate or salicylate salts in rats
23. In vitro evaluation of a series of azone analogs as dermal penetration enhancers: IV. Amines
24. Ion pair transport across membranes
25. Influence of lipophilic counter ions on the transport of ionizable hydrophilic drugs
26. Effect of topical vehicle composition on the in vitro release of fluocinolone acetonide and its acetate ester
27. Quaternary ammonium compounds in cosmetics
28. Applications of ion-pair concept to hydrophilic substances with special emphasis on peptides
29. Transport of organic ions through lipid bilayers
30. Optimization of topical therapy: Partitioning of drugs into stratum corneum
31. Use of a pH differential to pump an anion across a non-aqueous phase
32. The permeability of mammalian skin to ions
33. Influence of ionisation and ion-pair formation on lipophilicity of some 4-hydroxycoumarin derivatives in the octanol-water system
34. Factors determining drug residence in skin during transdermal absorption; studies on β-blocking agents
35. Calculation of partial molal volume in micellar systems