Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan

Drug Metabolism and Disposition

Volumn 28, Issue 10, 2000, Pages 1146-1148

  Nishino, Akiko ^c   Kato, Yukio ^a,b   Igarashi, Takashi ^c   Sugiyama, Yuichi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II ANTAGONIST; GLUCURONIDE; GLUTATHIONE PEROXIDASE; TELMISARTAN; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; DRUG BINDING; DRUG CLEARANCE; DRUG TRANSPORT; GENETIC DISORDER; GLUCURONIDATION; HYPERBILIRUBINEMIA; INTRAHEPATIC BILE DUCT; LIVER MICROSOME; MEMBRANE TRANSPORT; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANION TRANSPORT PROTEINS; BENZIMIDAZOLES; BENZOATES; BILIARY TRACT; CARBON RADIOISOTOPES; CARRIER PROTEINS; GLUCURONIDES; HYPERBILIRUBINEMIA; INJECTIONS, INTRAVENOUS; RATS; RATS, MUTANT STRAINS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0033815393     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats
2. Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium
3. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane
4. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
5. Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes
6. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP)
7. Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats
8. ATP-dependent transport of β-estradiol 17-(β-D-glucuronide) in rat canalicular membrane vesicles
9. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277