Automated assay optimization with integrated statistics and smart robotics

Journal of Biomolecular Screening

Volumn 5, Issue 4, 2000, Pages 213-225

  Taylor, Paul B ^a   Stewart, Frances P ^a   Dunnington, Damien J ^a,b   Quinn, Sean T ^a   Schulz, Christina K ^a   Vaidya, Kalindi S ^a   Kurali, Edit ^a   Lane, Tonia R ^a   Xiong, Wenfang C ^a   Sherrill, Timothy P ^c   Snider, John S ^c   Terpstra, Nathan D ^c   Hertzberg, Robert P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b SANOFI   (France)

^c Beckman Coulter Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND;

ANALYTIC METHOD; ARTICLE; BIOASSAY; CELL VIABILITY; DRUG SCREENING; ENZYME ASSAY; LIGAND BINDING; MOLECULAR STABILITY; PRIORITY JOURNAL; PRODUCTIVITY; PROTEIN AGGREGATION; ROBOTICS; STATISTICAL ANALYSIS; TASK PERFORMANCE; VALIDATION PROCESS;

EID: 0033812629     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/108705710000500404     Document Type: Article

References (10)

1. Experimental design for high throughput screening
2. Experimental design: A useful tool for PCR optimization
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4. 9 full factorial chemical library
5. Optimizing conditions for the growth of Lactobacillus casei YIT 9018 in tryptone-yeast extract-glucose medium by using response surface methodology
6. Use of the factorial design and quadratic response surface models to evaluate the fosinopril and hydrochlorothiazide combination therapy in hypertension
7. A simple statistical parameter for use in evaluation and validation of high throughput screening assays