Prevention by dexrazoxane of down-regulation of ryanodine receptor gene expression in anthracycline cardiomyopathy in the rat

British Journal of Pharmacology

Volumn 131, Issue 1, 2000, Pages 1-4

  Burke, Briant E ^a,b   Gambliel, Hervé ^a,b   Olson, Richard D ^a,b,c   Bauer, Frederic K ^a   Cusack, Barry J ^a,b,c  

^a Boise VA Medical Center   (United States)

^b MSTI/MSMRI Research Institute   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Anthracycline cardiotoxicity; Cardioprotectant; Dexrazoxane; Ryanodine receptor; Sarcoplasmic reticulum

Indexed keywords

ANTHRACYCLINE; CALCIUM ION; DAUNORUBICIN; RAZOXANE; RYANODINE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM METABOLISM; CARDIOMYOPATHY; CARDIOTOXICITY; CONTROLLED STUDY; DOWN REGULATION; DRUG INDUCED DISEASE; GENE EXPRESSION; HEART PROTECTION; HISTOPATHOLOGY; IRON CHELATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

EID: 0033812001     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703538     Document Type: Article

References (16)

1. Cardiotoxicity of parenterally administered iron complexes
2. Sacroplasmic reticulum genes are selectively down-regulated in cardiomyopathy produced by doxorubicin in rabbits
3. Single-step method of RNA isolation by acid guanidinium thiocyanate phenol-chloroform extraction
4. Doxorubicin cardiomyopathy is associated with decrease in calcium release channel of SR in a chronic rabbit model
5. Dexrazoxane prevents systolic dysfunction in chronic daunorubicin cardiotoxicity in the Fischer 344 rat
6. Ribonuclease protection assay
7. Timing of treatment of ICRF-187 and its effect on chronic doxorubicin cardiotoxicity
8. Redox regulation of cellular signalling
9. Iron (II) is a modulator of ryanodine-sensitive calcium channels of cardiac muscle sacroplasmic reticulum
10. Role of iron in anthracycline cardiotoxicity: New tune for an old song?
11. The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cystolic fractions from human myocardium
12. Doxorubicin cardiotoxicity: Analysis of prevailing hypotheses
13. Sarcoplasmic reticulum in heart failure: Central player or bystander?
14. Effect of ICRF-187 pretreatment against doxorubicin-induced delayed cardiotoxicity in the rat
15. The protective activity of ICRF-187 against doxorubicin-induced cardiotoxicity in the rat
16. The anthracycline antineoplastic drugs