The interaction between oxidised chylomicron remnants and the aorta of rats fed a normocholesterolaemic or hypercholesterolaemic diet

Journal of Vascular Research

Volumn 37, Issue 4, 2000, Pages 265-275

  Grieve, David J ^a   Avella, Michael A ^a   Elliott, Jonathan ^a   Botham, Kathleen M ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Hypercholesterolaemia; Nitric oxide; Oxidised chylomicron remnants; Rat aorta

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIMYCIN; CARBACHOL; CHYLOMICRON; COPPER SULFATE; LIPOPROTEIN; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENDOTHELIUM LESION; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; VASCULAR RING;

EID: 0033808235     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000025740     Document Type: Article

References (35)

1. Woodman OL: Modulation of vasoconstriction by endothelium-derived nitric oxide: The influence of vascular disease. Clin Exp Pharmacol Physiol 1995;22:585-591.
2. Cox DA, Cohen ML: Effects of oxidized low-density lipoproteinon vascular contraction and relaxation: Clinical and pharmacological implications in atherosclerosis. Pharmacol Rev 1996;48:3-19.
3. Doi H, Kugiyama K, Oligushi M, Sugiyama S, Matsumura T, Ohta Y, Nakano T, Nakajima K, Yasue H: Remnants of chylomicron and very low density lipoprotein impair endothelium-dependent vasorelaxation. Atherosclerosis 1998;137:341-349.
4. Grieve DJ, Avella MA, Botham KM, Elliott J: Effects of chylomicrons and chylomicron remnants on endothelium-dependent relaxation of rat aorta. Eur J Pharmacol 1998;348:181-190.
5. Grieve DJ, Avella MA, Botham KM, Elliott J: The influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta. Atherosclerosis 1998;139:273-281.
6. Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D: Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA 1984;81:3883-3887.
7. Simon BC, Cunningham LD, Cohen RA: Oxidised low density lipoproteins cause contraction and inhibit relaxation in the pig coronary artery. J Clin Invest 1990;86:75-79.
8. Tanner FC, Noll G, Boulanger CM, Luscher TF: Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Circulation 1991;83:2012-2020.
9. Grieve DJ, Avella MA, Botham KM, Elliott J: Chylomicron remnants potentiate phenylephrine-induced contractions of rat aorta by an endothelium-dependent mechanism. Atherosclerosis, in press.
10. Verbeuren TJ, Jordaens FH, van Hove CE, van Hoydonek A-E, Herman AG: Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta. Eur J Pharmacol 1990;191:173-184.
11. Lefer AM, Ma X: Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium. Arterioscler Thromb 1993;13:771-776.
12. Laight DW, Matz J, Caesar B, Carrier MJ, Anggard EE: Investigation of endogenous nitric oxide vascular function in the carotid artery of cholesterol-fed rabbits. Br J Pharmacol 1996; 117:1471-1474.
13. Smith EB, Slater RS: Relationship between low density lipoprotein in aortic intima and serum-lipid levels. Lancet 1972;i:463-469.
14. Wiklund O, Bjornheden T, Olofsson S-O, Bondjers G: Influx and cellular degradation of low density lipoproteins in rabbit aorta determined in an in vitro perfusion system. Arteriosclerosis 1987;7:565-571.
15. Wiklund O, Mattsson L, Bjornheden T, Camejo G, Bondjers G: Uptake and degradation of low density lipoproteins in atherosclerotic rabbit aorta: Role of local LDL modification. J Lipid Res 1991;32:55-62.
16. Stender S, Zilversmit DB: Comparison of cholesteryl ester transfer from chylomicrons and other plasma lipoproteins to aortic intima media of cholesterol-fed rabbits. Arteriosclerosis 1982;2:493-499.
17. Mamo JCL, Wheeler JR: Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low-density lipoprotein, high-density lipoprotein, and albumin. Coron Artery Dis 1994;5:695-705.
18. Proctor SD, Mamo JCL: Arterial fatty lesions have increased uptake of chylomicron remnants but not low-density lipoproteins. Coron Artery Dis 1996;7:239-245.
19. Proctor SD, Pabla CK, Mamo JCL: Arterial uptake of chylomicrons and low density lipoproteins in insulin deficient rats and rabbits. Atherosclerosis 1997;134:314.
20. Cole TG, Kuisk I, Patsch W, Schonfeld G: Effects of high cholesterol diets on rat plasma lipoproteins and lipoprotein-ccll interactions. J Lipid Res 1984;25:593-603.
21. Sehuschke DA, Joshua IG, Miller FN: Comparison of early microcirculatory and aortic changes in hypercholesterolemic rats. Arterioscler Thromb 1991;11:154-160.
22. Cappelli-Bigazzi M, Rubattu S, Battaglia C, Russo R, Enea I, Ambrosio G, Chiariello M, Volpe M: Effects of high-cholesterol and atherogenic diets on vascular relaxation in spontaneously hypertensive rats. Am J Physiol 1997; 273:H647-H654.
23. Mahley RW, Holcombe KS: Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat. J Lipid Res 1977; 18:314-324.
24. Cortner JA, Coates PM, Le NA, Cryer DR, Ragni MC, Faulkner A, Langer T: Kinetics of chylomicron remnant clearance in normal and in hyperlipoproteinemic subjects. J Lipid Res 1987;28:195-206.
25. Bullock GR, Taylor SG, Weston AH: Influence of the vascular endothelium on agonist-induced contractions and relaxations in rat aorta. Br J Pharmacol 1986;89:819-830.
26. Martin GR, Bolofo ML, Giles H: Inhibition of endothelium-dependent vasorelaxation by arginine analogues: A pharmacological analysis of agonist and tissue dependence. Br J Pharmacol 1992;105:643-652.
27. Grieve DJ, Avella MA, Elliott J, Botham KM: Effects of oxidised chylomicron remnants on endothelial cell function in the perfused and freshly isolated rat aorta. Br J Pharmacol 1998; 123:300P.
28. Dominiczak AF, Quilley J, Bohr DF: Contraction and relaxation of rat aorta in response to ATP. Am J Physiol 1991;261:H243-H251.
29. Shimokawa H, Vanhoutte PM: Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ Res 1989;64: 900-914.
30. Zeiher AM, Drexler H, Wollschlager H, Just H: Modulation of coronary vasomotor tone in humans. Circulation 1991;83:391-401.
31. Kurozumi T, Imamura T, Tanaka K, Yae Y, Koga S: Permeation and deposition of fibrinogen and low-density lipoprotein in the aorta and cerebral artery of rabbits. Br J Exp Pathol 1984;65:355-364.
32. Yamauchi Y, Hoff HF: Apolipoprotcin B accumulation and development of foam cell lesions in coronary arteries of hypercholesterolemic swine. Lab Invest 1984;51:325-332.
33. Coutard M, Roullet JB, Chamouard C, Pellegrin MO, Landais P, Drucke T, Laeour B: Diet-induced hyperlipoproteinemia and lipid accumulation within spontaneous arterial lesions in the rat. Artery 1989;16:118-139.
34. Niki E, Yamamoto Y, Takahashi M, Yamamoto K, Yamamoto Y, Komuro E, Miki M, Yasuda H, Mino M: Free radical-mediated damage of blood and its inhibition by antioxidants. J Nutr Sci Vitaminol 1988;34:507-512.
35. Vine DF, Croft KD, Beilin LJ, Mamo JCL: Absorption of dietary cholesterol oxidation products and incorporation into rat lymph chylomicrons. Lipids 1997;32:887-893.