A comparison between acute exposures to ethanol and acetaldehyde on neurotoxicity, nitric oxide production and NMDA-induced excitotoxicity in primary cultures of cortical neurons

Chinese Journal of Physiology

Volumn 43, Issue 3, 2000, Pages 131-138

  Wang, Jiz Yuh ^a   Wang, Ju Yu ^a,b   Wang, Yung ^a   Wang, Jia Yi ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Acetaldehyde; Cortical neurons; Ethanol; Neurotoxicity; Nitric oxide; NMDA

Indexed keywords

ACETALDEHYDE; ALCOHOL; DIZOCILPINE; LACTATE DEHYDROGENASE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE; NITRITE;

ALCOHOL METABOLISM; ANIMAL CELL; ARTICLE; BRAIN CELL; CELL DEATH; CELL VIABILITY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FETUS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT;

EID: 0033807802     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. 2 system. Biochem. Pharmacol. 44: 93-98, 1992.
2. Chandler, L.J., Sumners, C. and Crews, F.T. Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures. Alcohol. Clin. Exp. Res. 17: 54-60, 1993.
3. Choi, D.W. Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci. Lett. 58: 293-297, 1985.
4. Choi, D.W. Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7: 369-379, 1987.
5. Crews, F.T., Steck, J.C., Chandler, L.J., Yu, C.J. and Day, A. Ethanol, stroke, brain damage, and excitotoxicity. Pharmacol. Biochem. Behav. 59: 981-991, 1998.
6. Dawson, V.L., Dawson, T.M., London, E.D., Bredt, D.S. and Snyder, S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88: 6368-6371, 1991.
7. 2+ in dissociated brain cells. Brain Res. 499: 383-387, 1989.
8. Dildy-Mayfield, J.E. and Harris, R.A. Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 262: 487-494, 1992.
9. 2+ concentration by ethanol. J. Neurochem. 56: 1536-1543, 1991.
10. Fink, K. and Gothert, M. Inhibition of N-methyl-D-aspartate-induced noradrenaline release by alcohol is related to their hydrophobicity. Eur. J. Pharmacol. 191: 225-229, 1990.
11. Gibson, M.A., Butters, N.S., Reynolds, J.N. and Brien, J.F. Effects of chronic prenatal ethanol exposure on locomotor activity, and hippocampal weight, neurons, and nitric oxide synthase activity of the young postnatal guinea pig. Neurotoxicol. Teratol. 22: 183-192, 2000.
12. Gill, K., Menez, J.F., Lucas, D. and Deitrich, R.A. Enzymatic production of acetaldehyde from ethanol in rat brain tissue. Alcohol. Clin. Exp. Res. 16: 910-915, 1992.
13. Gonzales, R.A. and Hoffman, P.L. Receptor-gated ion channels may be selective CNS targets for ethanol. Trends. Pharmacol. Sci. 12: 1-3, 1991.
14. Gonzales, R.A. and Woodward, J.J. Ethanol inhibits N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat cortical slices. J. Pharmacol. Exp. Ther. 253: 1138-1144, 1990.
15. 15 N]nitrate in biological fluids. Anal. Biochem. 126: 131-138, 1982.
16. Greenberg, S., Xie, J., Wang, Y., Kolls, J., Shellito, J., Nelson, S. and Summer, W. Ethanol relaxes pulmonary artery by release of prostaglandin and nitric oxide. Alcohol 10: 21-29, 1993.
17. Hoffman, P.L., Rabe, C.S., Moses, F. and Tabakoff, B. N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J. Neurochem. 52: 1937-1940, 1989.
18. Holownia, A., Ledig, M., Braszko, J.J. and Menez, J.F. Acetaldehyde cytotoxicity in cultured rat astrocytes. Brain Res. 833: 202-208, 1999.
19. Ikeda, M., Komiyama, T., Sato, I., Himi, T. and Murota, S. Neuronal nitric oxide synthase is resistant to ethanol. Life Sci. 64: 1623-1630, 1999.
20. Kashii, S., Mandai, M., Kikuchi, M., Honda, Y., Tamura, Y., Kaneda, K. and Akaike, A. Dual actions of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity in cultured retinal neurons. Brain Res. 711: 93-101, 1996.
21. Koh, J. Y. and Choi, D.W. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods. 20: 83-90, 1987.
22. Kuriyama, K., Ohkuma, S., Tomono, S. and Hirouchi, M. Effects of alcohol and acetaldehyde on metabolism and function of neurotransmitter systems in cerebral cortical neurons in primary culture. Alcohol Alcohol. Suppl 1: 685-689, 1987.
23. Lima-Landman, M.T. and Albuquerque, E.X. Ethanol potentiates and blocks NMDA-activated single-channel currents in rat hippocampal pyramidal cells. FEBS Lett. 247: 61-67, 1989.
24. Lovinger, D.M., White, G. and Weight, F.F. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243: 1721-1724, 1989.
25. Lovinger, D.M., White, G. and Weight, F.F. NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J. Neurosci. 10: 1372-1379, 1990.
26. Lustig, H. von Brauchitsch, K., Chan, J. and Greenberg, D. Ethanol and excitotoxicity in cultured cortical neurons: differential sensitivity of N-methyl-D-aspartate and sodium nitroprusside toxicity. J. Neurochem. 59: 2193-2200, 1992.
27. 2+ influx elicited by glutamate: role in neuronal death, Mol. Pharmacol. 36: 106-112, 1989.
28. Mantle, D. and Preedy, V.R. Free radicals as mediators of alcohol toxicity. Adverse Drug React. Toxicol. Rev. 18: 235-251, 1999.
29. Morrisett, R.A., Martin, D., Oetting, T.A., Lewis, D.V., Wilson, W. A. and Swartzwelder, H.S. Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner Neuropharmacology 30: 1173-1178, 1991.
30. Naassila, M., Roux, F., Beauge, F. and Daust, M. Alcohol potentiates LPS-induced iNOS gene expression and nitrite formation in a rat BBB (endothelial) cell line. Eur. J. Pharmacol. 313: 273-277, 1996.
31. Rabe, C. S. and Tabakoff, B. Glycine site-directed agonists reverse the actions of ethanol at the N-methyl-D-aspartate receptor. Mol. Pharmacol. 38: 753-757, 1990.
32. Rothman, S.M. The neurotoxicity of excitatory amino acids is produced by passive chloride influx. J. Neurosci. 5: 1483-1489, 1985.
33. Rudolph, J.G., Lemasters, J.J. and Crews, F.T. Effects of chronic ethanol exposure on oxidation and NMDA-stimulated neuronal death in primary cortical neuronal cultures. Alcohol. Clin. Exp. Res. 22: 2080-2085, 1998.
34. Syapin, P.J. Alcohol and nitric oxide production by cells of the brain. Alcohol 16: 159-165, 1998.
35. Syapin, P. J. Ethanol inhibition of inducible nitric oxide synthase activity in C6 glioma cells. Alcohol. Clin. Exp. Res. 19: 262-267, 1995.
36. Upadhya, S.C., Tirumalai, P.S., Boyd, M.R., .Mori, T. and Ravindranath, V. Cytochrome P4502E (CYP2E) in brain: constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization. Arch. Biochem. Biophys. 373: 23-34, 2000.
37. Wang, J.-Y., Shum, A.Y.-C., Chao, C.C., Kuo, J.S. and Wang J.-Y. Production of macrophage inflammatory protein-2 (MIP-2) following hypoxia/reoxygenation in glial cells. Glia, in press, 2000.
38. Wang, J.-Y., Wang, J.-Y., Wang, J.Y., Shum, A.Y.-C. and Hwang, C.P. Ethanol modulates induction of nitric oxide synthase in glial cells by endotoxin. Life Sci. 63: 1571-1583, 1998.
39. Ward, R.J., Colantuoni, C., Dahchour, A., Quertemont, E. and De Witte, P. Acetaldehyde-induced changes in monoamine and amino acid extracellular microdialysate content of the nucleus accumbens. Neuropharmacology 36: 225-232,1997.
40. White, G., Lovinger, D.M. and Weight, F.F. Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron. Brain Res. 507: 332-336, 1990.
41. Wink, D., Hanbauer, I., Krishna, M., DeGraff, W., Gamson, J. and Mitchell, J. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proc. Natl. Acad. Sci. USA 90: 9813-9817, 1993.
42. Wink, D.A., Cook, J.A., Krishna, M.C., Hanbauer, I., DeGraff, W., Gamson, J. and Mitchell, J.B. Nitric oxide protects against alkyl peroxide-mediated cytotoxicity: further insights into the role nitric oxide plays in oxidative stress. Arch. Biochem. Biophys. 319: 402-407, 1995.
43. Zimatkin, S.M. and Lindros, K.O. Distribution of catalase in rat brain: aminergic neurons as possible targets for ethanol effects. Alcohol Alcohol. 31: 167-174, 1996.
44. Zimatkin, S.M., Liopo, A.V. and Deitrich, R.A. Oxidation of ethanol to acetaldehyde in brain and the possible behavioral consequences. Adv. Exp. Med. Biol 463: 231-236, 1999.