Effects of chronic prenatal ethanol exposure on locomotor activity, and hippocampal weight, neurons, and nitric oxide synthase activity of the young postnatal guinea pig

Neurotoxicology and Teratology

Volumn 22, Issue 2, 2000, Pages 183-192

  Gibson, M A S ^a   Butters, N S ^a   Reynolds, J N ^a   Brien, J F ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

CA1 pyramidal cells; Chronic prenatal ethanol exposure; Hippocampal weight; Locomotor activity; Nitric oxide synthase; Postnatal guinea pig

Indexed keywords

ALCOHOL; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; FETUS; GUINEA PIG; HIPPOCAMPUS; HISTOLOGY; HYPERACTIVITY; LOCOMOTION; NERVE CELL; NEUROTOXICITY; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROGENY; PYRAMIDAL NERVE CELL;

ABORTION, SPONTANEOUS; ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; BIRTH WEIGHT; DENTATE GYRUS; FEMALE; GUINEA PIGS; HIPPOCAMPUS; LITTER SIZE; MALE; MOTOR ACTIVITY; NEURONS; NITRIC OXIDE SYNTHASE; ORGAN SIZE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PRENATAL EXPOSURE DELAYED EFFECTS; PYRAMIDAL CELLS;

CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0034603386     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(99)00074-4     Document Type: Article

References (50)

1. Abdollah S., Catlin M.C., Brien J.F. Ethanol neuro-behavioural teratogenesis in the guinea pig. Behavioural dysfunction and hippocampal morphological change Can J Physiol Pharmacol. 71:1993;776-782.
2. Abdollah S., Brien J.F. Effect of chronic maternal ethanol administration on glutamate and NMDA binding sites in the hippocampus of the near-term fetal guinea pig. Alcohol. 12:1995;377-382.
3. Abel E.L., Jacobson S., Sherwin B.T. In utero alcohol exposure. Functional and structural brain damage Neurobehav Toxicol Teratol. 5:1983;363-366.
4. Abel E.L. Fetal Alcohol Abuse Syndrome. 1998;Plenum Press, New York.
5. Babcock A.M., Baker D.A., Lovec R. Locomotor activity in the ischemic gerbil. Brain Res. 625:1993;351-354.
6. Barnes D.E., Walker D.W. Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus. Dev Brain Res. 1:1981;3-24.
7. Bonthius D.J., West J.R. Alcohol-induced neuronal loss in developing rats. Increased brain damage with binge exposure Alcohol Clin Exp Res. 14:1990;107-118.
8. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
9. Bredt D.S., Snyder S.H. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA. 87:1990;682-685.
10. Bredt D.S., Snyder S.H. Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory ganglia, and olfactory neurons. Neuron. 13:1994;301-313.
11. Catlin M.C., Abdollah S., Brien J.F. Dose-dependent effects of prenatal ethanol exposure in the guinea pig. Alcohol. 10:1993;109-115.
12. Clarke D.W., Steenaart N.A.E., Slack C.J., Brien J.F. Pharmacokinetics of ethanol and its metabolite, acetaldehyde, and fetolethality in the third-trimester pregnant guinea pig for oral administration of acute, multiple-dose ethanol. Can J Physiol Pharmacol. 64:1986;1060-1067.
13. Clarren S.K., Smith D.W. The fetal alcohol syndrome. N Engl J Med. 298:1978;1063-1067.
14. Colbourne F., Corbett D. Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil. Brain Res. 654:1994;265-272.
15. Collingridge G.L., Lester R.A.J. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev. 40:1989;143-210.
16. Davenport H.A. Histological and Histochemical Techniques. 1960;W.B. Saunders, Philadelphia.
17. Davies D.L., Smith D.E. A golgi study of mouse hippocampal CA1 pyramidal neurons following perinatal ethanol exposure. Neurosci Lett. 26:1981;49-54.
18. Dawson T.M., Snyder S.H. Gases as biological messengers. Nitric oxide and carbon monoxide in the brain J Neurosci. 14:1994;5147-5159.
19. Delivoria-Papadopoulos M., McGowan J.E. Oxygen transport and delivery. Polin R.A., Fox W.W. Fetal and Neonatal Physiology, Vol. 1. 1998;1105-1117 W.B. Saunders Company, Philadelphia.
20. Dobbing J., Sands J. Comparative aspects of the brain growth spurt. Early Hum Dev. 3:1979;79-83.
21. Driscoll C.D., Streissguth A.P., Riley E.P. Prenatal alcohol exposure. Comparability of effects in humans and animal models Neurotoxicol Teratol. 12:1990;231-237.
22. Elvidge H. Production of dated pregnant guinea pigs without post-partum matings. J Anim Tech. 23:1972;111-117.
23. Farinelli S.E., Park D.S., Greene L.A. Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism. J Neurosci. 16:1996;2325-2334.
24. Forstermann U., Closs E.I., Pollock J.S., Nakane M., Schwarz P., Gath I., Kleinert H. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions Hypertension. 23:1994;1121-1131.
25. Fuchs A.R., Husslein P., Sumulong L., Micha J.P., Dawood M.Y., Fuchs F. Plasma levels of oxytocin and 13,14-dihydro-15-keto prostaglandin F2α in preterm labor and the effect of ethanol and ritodrine. Am J Obstet Gynecol. 144:1982;753-759.
26. Garthwaite J., Charles S.L., Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature. 336:1987;385-388.
27. Institute of Medicine (U.S.), Fetal Alcohol Syndrome: Diagnosis, Epidemiology, Prevention, and Treatment, K. Stratton, C. Howe, F. Battaglia, (Eds.), National Academy Press, Washington, DC, 1996.
28. Jaffrey S.R., Snyder S.H. Nitric oxide. A neural messenger Annu Rev Cell Dev Biol. 11:1995;417-440.
29. Kimura K.A., Parr A.M., Brien J.F. Effect of chronic maternal ethanol administration on nitric oxide synthase activity in the hippocampus of the mature fetal guinea pig. Alcohol Clin Exp Res. 20:1996;948-953.
30. Kimura K.A., Brien J.F. Hippocampal nitric oxide synthase in the fetal guinea pig. Effects of chronic prenatal ethanol exposure Dev Brain Res. 106:1998;39-46.
31. Kimura K.A., Chiu J., Reynolds J.N., Brien J.F. Effect of chronic prenatal ethanol exposure on nitric oxide synthase I and III proteins in the hippocampus of the near-term fetal guinea pig. Neurotoxicol Teratol. 21:1999;251-259.
32. Kimura K.A., Reynolds J.N., Brien J.F. Ontogeny of nitric oxide synthase I and III protein expression and enzymatic activity in the guinea pig hippocampus. Dev Brain Res. 116:1999;211-216.
33. Kuge T., Asayama T., Kakuta S., Murakami K., Ishikawa Y., Kuroda M., Imai T., Seki K., Omoto M., Kishi K. Effect of ethanol on the development and maturation of synapses in the rat hippocampus. A quantitative electron-microscopic study Environ Res. 62:1993;99-105.
34. Lauerson N.H., Wilson K.H., Fuchs F.F. The inhibitory effect of ethanol on oxytocin-induced labor at term. J Reprod Med. 26:1981;547-550.
35. G-monomethyl-L-arginine Teratology. 49:1994;452-464.
36. Mattson S.N., Riley E.P. A review of the neurobehavioral deficits in children with fetal alcohol syndrome or prenatal exposure to alcohol. Alcohol Clin Exp Res. 22:1998;279-294.
37. Miller M.W. Generation of neurons in the rat dentate gyrus and hippocampus. Effects of prenatal and postnatal treatment with ethanol Alcohol Clin Exp Res. 19:1995;1500-1509.
38. Nakanishi S. Molecular diversity of glutamate receptors and implication for brain function. Science. 258:1992;597-603.
39. Nishimura H., Shiota K. Summary of comparative embryology and teratology. Wilson J.G., Fraser F.C. Handbook of Teratology, Vol. 3. 1977;119-154 Plenum Press, New York.
40. Pantazis N.J., West J.R., Dai D. The nitric oxide-cyclic GMP pathway plays an essential role in both promoting cell survival of cerebellar granule cells in culture and protecting the cells against ethanol neurotoxicity. J Neurochem. 70:1998;1826-1838.
41. Reynolds J.D., Brien J.F. Ethanol neurobehavioural teratogenesis and the role of L-glutamate in the fetal hippocampus. Can J Physiol Pharmacol. 73:1995;1209-1223.
42. Riley E.P., Barron S., Hannigan J.H. Response inhibition deficits following prenatal alcohol exposure. A comparison to the effects of hippocampal lesions in rats West J.R. Alcohol and Brain Development. 1986;71-102 Oxford University Press, New York.
43. Southam E., Garthwaite J. The nitric oxide-cyclic GMP signalling pathway in rat brain. Neuropharmacology. 32:1993;1267-1277.
44. Steenaart N.A.E., Clarke D.W., Brien J.F. Gas-liquid chromatographic analysis of ethanol and acetaldehyde in blood with minimal artifactual acetaldehyde formation. J Pharmacol Methods. 14:1985;199-212.
45. Streissguth A.P., Landesman-Dwyer S., Martin J.C., Smith D.W. Teratogenic effects of alcohol in humans and laboratory animals. Science. 209:1980;353-361.
46. Tanaka H., Nasu F., Inomata K. Fetal alcohol effects. Decreased synaptic formations in the field CA3 of fetal hippocampus Int J Dev Neurosci. 9:1991;509-517.
47. Traub R.D., Miles R. Neuronal Networks of the Hippocampus. 1991;Cambridge University Press, Cambridge.
48. West J.R., Hodges C.A., Black A.C. Prenatal exposure to ethanol alters the organization of hippocampal mossy fibers in rats. Science. 211:1981;957-959.
49. West J.R., Pierce D.R. Perinatal alcohol exposure and neuronal damage. West J.R. Alcohol and Brain Development. 1986;120-157 Oxford University Press, New York.
50. Zou J.Y., Marinez D.B., Neafsey E.J., Collins M.A. Binge ethanol-induced brain damage in rats. Effect of inhibitors of nitric oxide synthase Alcohol Clin Exp Res. 20:1996;1406-1411.