GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin

Pancreas

Volumn 21, Issue 3, 2000, Pages 219-225

  Parker, Eliza M ^a   Zaman, Munir M ^a   Freedman, Steven D ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Acini; Caveolin; GPI; src

Indexed keywords

ANNEXIN; CAVEOLIN; CELL MEMBRANE PROTEIN; CYTOCHALASIN; GENISTEIN; HORSERADISH PEROXIDASE; PROTEIN GP2; PROTEIN GPI; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TYRPHOSTIN; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ARTICLE; CELL MEMBRANE; ENDOCYTOSIS; ENZYME REGULATION; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; ANNEXINS; BLOTTING, WESTERN; CAVEOLIN 1; CAVEOLINS; CELL MEMBRANE; ENDOCYTOSIS; IMMUNOSORBENT TECHNIQUES; MEMBRANE GLYCOPROTEINS; MICE; PANCREAS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-YES; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SRC-FAMILY KINASES;

EID: 0033807466     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200010000-00001     Document Type: Article

References (26)

1. Acinar lumen pH regulates endocytosis, but not exocytosis, at the apical plasma membrane of pancreatic acinar cells
2. Cleavage of GPI-anchored proteins from the plasma membrane activates apical endocytosis in pancreatic acinar cells
3. Endocytosis at the apical plasma membrane of pancreatic acinar cells is regulated by tyrosine kinases
4. GPI-anchored cell-surface molecules complexed to tyrosine kinases
5. The association between glycosylphosphatidylinositol anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes
6. Signals determining protein tyrosine kinase and glycosyl phosphatidylinositol anchored protein targeting to a glycolipid-enriched membrane fraction
7. Triton X-100-resistant membrane complexes from cultured kidney epithelial cells contain the src family protein tyrosine kinase p62(yes)
8. Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins from a caveolin-rich insoluble complex in MDCK cells
9. 2+
10. Sorting of GPI-anchored proteins to glycolipid enriched membrane subdomains during transport to apical cell surface
11. Dynamic changes of the luminal plasmalemma in stimulated parotid acinar cells: A freeze fracture study
12. Reinternalization of secretory proteins during membrane recycling in rat pancreatic acinar cells
13. Pathways of endocytosis from luminal plasma membrane in rat exocrine pancreas
14. A single gene encodes membrane-bound and free forms of GP2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes
15. Isolation of the cDNA encoding glycoprorein-2 (GP-2), the major zymogen granule membrane protein
16. The major protein of pancreatic zymogen granule membranes (GP-2) is anchored via covalent bonds to phosphatidylinositol
17. Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells
18. Physiological functions of the yes proto-oncogene protein
19. Association of p60c src with endosomal membranes in mammalian fibroblasts
20. Src kinase pathways in extracellular Ca(2+)-dependent pancreatic enzyme secretion
21. Caveolin forms a heterooligomeric protein complex that interacts with an apical GPI-linked protein: Implications in the biogenesis of caveolae
22. Phosphorylation of caveolin by src tyrosine kinases
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24. Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells
25. Cytoskeleto-dependent endocytosis is required for apical type 1 angiotensin II receptor-mediated phospholipase C activation in cultured rat proximal tubule cells
26. The effects of cytochalasin D and phorbol myristate acetate on the apical endocytosis of ricin in polarised Caco-2 cells